Primary chemically induced tumors induce profound immunosuppression concomitant with apoptosis and alterations in signal transduction in T cells and NK cells.

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.

1960 • 736 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.

1997 • 342 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Immunodepression and Malignancy

1976 • 310 citations

The neglected role of type I interferon in the T-cell response: implications for its clinical use

1996 • 306 citations

Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

1998 • 238 citations

Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

1995 • 217 citations

Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma.

1996 • 216 citations

Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites.

1996 • 215 citations

Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression

1998 • 193 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A *0201-restricted E7-encoded epitope.

1996 • 180 citations

Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.

1996 • 169 citations

Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO‐1/Fas) ligand expression in microglial cells

1998 • 132 citations

Analysis of the T cell response to tumor and viral peptide antigens by an IFNγ-ELISPOT assay

1997 • 113 citations

Escape from Host-Antitumor Immunity

1997 • 81 citations

Alterations in T cells of cancer-bearers: whence specificity?

1996 • 63 citations

T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.

1997 • 59 citations

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity.

1995 • 57 citations

High Frequency of Cancer Patients with Abnormal Assembly of the T Cell Receptor‐CD3 Complex in Peripheral Blood T Lymphocytes

1994 • 52 citations

Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice.

1995 • 47 citations

Characterization of the anti-tumor immune response in human cancers and strategies for immunotherapy

1994 • 38 citations

Monocyte-Dependent Death of Freshly Isolated T Lymphocytes: Induction by Phorbolester and Mitogens and Differential Effects of Catalase

1998 • 32 citations

Impaired cytokine production in whole blood cell cultures of patients with urological carcinomas

1993 • 23 citations

A chemical carcinogen, 3-methylcholanthrene, alters T-cell function and induces T-suppressor cells in a mouse model system.

1983 • 21 citations

Molecular basis of T cell dysfunction in cancer is influenced by the paracrine secretion of tumor-derived IL-2.

1996 • 21 citations

Lymphocytes infiltrating colorectal cancer have low proliferative capacity but can secrete normal levels of interferon γ

1995 • 19 citations

Immunotherapy of cancer by peptide-based vaccines for the induction of tumor-specific T cell immunity

1996 • 18 citations

Immunosuppressive effects of 3-methylcholanthrene given intratracheally in various inbred strains of mice.

1977 • 16 citations