Map kinase signaling pathways and hematologic malignancies

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

2001 • 1,520 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

2000 • 785 citations

Ras and Rho GTPases

2000 • 779 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Phase I Trial of the Proteasome Inhibitor PS-341 in Patients With Refractory Hematologic Malignancies

2002 • 771 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

1999 • 744 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

2003 • 721 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Mixed-lineage kinase control of JNK and p38 MAPK pathways

2002 • 556 citations

Interleukin-6 in human multiple myeloma

1995 • 550 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Small GTP-Binding Proteins

1992 • 526 citations

The Pathophysiology of Acquired Aplastic Anemia

1997 • 522 citations

Essential Role of p38α MAP Kinase in Placental but Not Embryonic Cardiovascular Development

2000 • 509 citations

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

1997 • 504 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.

2002 • 462 citations

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

2001 • 458 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Pharmacological inhibitors of MAPK pathways

2002 • 437 citations

New Insights into the Control of MAP Kinase Pathways

1999 • 431 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

2001 • 420 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

MAPK-regulated transcription: a continuously variable gene switch?

2002 • 404 citations

Acute promyelocytic leukemia: evolving therapeutic strategies

2002 • 399 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.

1983 • 373 citations

Essential role for p38α mitogen-activated protein kinase in placental angiogenesis

2000 • 370 citations

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappaB

2002 • 369 citations

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.

1988 • 367 citations

Primary Structure of BMK1: A New Mammalian MAP Kinase

1995 • 345 citations

Requirement for p38α in Erythropoietin Expression

2000 • 343 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

2001 • 311 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

2002 • 302 citations

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

2000 • 300 citations

Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells

1998 • 300 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 278 citations

Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma

1995 • 275 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

2000 • 272 citations

Signaling pathways activated by interferons

1999 • 268 citations

Perspectives on the development of a molecularly targeted agent

2002 • 267 citations

Primary Myeloma Cells Growing in SCID-hu Mice: A Model for Studying the Biology and Treatment of Myeloma and Its Manifestations

1998 • 261 citations

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

1998 • 254 citations

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ

2002 • 253 citations

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

2002 • 249 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses.

2000 • 242 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

Interleukin 6 is essential for in vivo development of B lineage neoplasms.

1995 • 233 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

Chronic myeloid leukemia: current treatment options

2001 • 229 citations

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1997 • 228 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

1999 • 226 citations

The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein–kinase–dependent mechanism

2002 • 225 citations

The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1

1996 • 221 citations

Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

1999 • 212 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation

1998 • 205 citations

Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection

2000 • 205 citations

Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.

2002 • 197 citations

Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways

2000 • 197 citations

Studies of interferon as a regulator of hematopoietic cell proliferation.

1985 • 195 citations

The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins

2000 • 195 citations

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines

1996 • 190 citations

Signaling pathways activated by daunorubicin

2001 • 182 citations

p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

1997 • 176 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 176 citations

Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways

2000 • 175 citations

Untying the regulation of the Raf-1 kinase

2002 • 174 citations

Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism

1997 • 174 citations

Effect of recombinant interferons alpha and gamma on human bone marrow- derived megakaryocytic progenitor cells

1987 • 173 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

2000 • 171 citations

Kotlyarov, A. et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat. Cell Biol. 1, 94-97

1999 • 170 citations

Activation of the p38 Mitogen-activated Protein Kinase Mediates the Suppressive Effects of Type I Interferons and Transforming Growth Factor-β on Normal Hematopoiesis

2002 • 166 citations

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

2002 • 161 citations

Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid

2001 • 160 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

The p38 mitogen-activated protein kinase pathway and its role in interferon signaling

2003 • 155 citations

Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

2002 • 153 citations

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

1996 • 153 citations

Insulinlike growth factor–I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk

2002 • 152 citations

Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth

1999 • 152 citations

Involvement of protein kinase C and phosphatidylinositol 3–kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells

2002 • 149 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1997 • 147 citations

Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.

1993 • 145 citations

The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-α in BCR-ABL-expressing Cells

2001 • 143 citations

Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia

2000 • 143 citations

Synergistic Activation of MAP Kinase (ERK1/2) by Erythropoietin and Stem Cell Factor Is Essential for Expanded Erythropoiesis

1998 • 141 citations

Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2

1996 • 140 citations

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha.

1997 • 137 citations

MAP Kinase Signaling Specificity

2002 • 136 citations

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1998 • 134 citations

Functional expression of receptor activator of nuclear factor κB in Hodgkin disease cell lines

2001 • 133 citations

Constitutive Activation of Extracellular Signal-Regulated Kinase in Human Acute Leukemias: Combined Role of Activation of MEK, Hyperexpression of Extracellular Signal-Regulated Kinase, and Downregulation of a Phosphatase, PAC1

1999 • 132 citations

Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias

1993 • 131 citations

Cell-cycle–dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

2001 • 127 citations

Regulation of MAP kinases by docking domains

2001 • 127 citations

Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide

2002 • 125 citations

ERK8, a New Member of the Mitogen-activated Protein Kinase Family

2002 • 125 citations

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

2002 • 121 citations

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

2002 • 120 citations

Blast crisis in a murine model of chronic myelogenous leukemia.

1991 • 119 citations

A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth.

1997 • 117 citations

Signal transduction by MAP kinases in T lymphocytes

2001 • 117 citations

Interleukin-6–Induced Inhibition of Multiple Myeloma Cell Apoptosis: Support for the Hypothesis That Protection Is Mediated Via Inhibition of the JNK/SAPK Pathway

1998 • 113 citations

Activation of JNK Signaling Pathway by Erythropoietin, Thrombopoietin, and Interleukin-3

1997 • 110 citations

Constitutive Activation of Extracellular Signal-Regulated Kinase in Human Acute Leukemias: Combined Role of Activation of MEK, Hyperexpression of Extracellular Signal-Regulated Kinase, and Downregulation of a Phosphatase, PAC1

1999 • 110 citations

Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase

1999 • 106 citations

c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells

2002 • 106 citations

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

1996 • 104 citations

Cytokine, cytokine receptors, transduction signals, and oncogenes in human multiple myeloma.

1995 • 103 citations

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

2001 • 101 citations

Cutting Edge: Activation of the p38 Mitogen-Activated Protein Kinase Signaling Pathway Mediates Cytokine-Induced Hemopoietic Suppression in Aplastic Anemia

2002 • 98 citations

Distinct Signaling from Stem Cell Factor and Erythropoietin in HCD57 Cells

1997 • 98 citations

JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells

2000 • 96 citations

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

1998 • 94 citations

The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells

2000 • 94 citations

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6–independent mechanism

2002 • 94 citations

Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis.

1996 • 92 citations

Evidence for Involvement of Mitogen-Activated Protein Kinase, Rather than Stress-Activated Protein Kinase, in Potentiation of 1-β-d-Arabinofuranosylcytosine-Induced Apoptosis by Interruption of Protein Kinase C Signaling

1998 • 90 citations

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

2000 • 90 citations

Activation of p38 MAP Kinase Pathway by Erythropoietin and Interleukin-3

1997 • 89 citations

The Epstein–Barr Virus Latent Membrane Protein 1 Induces Interleukin-10 in Burkitt's Lymphoma Cells but Not in Hodgkin's Cells Involving the p38/SAPK2 Pathway

2001 • 85 citations

Interleukin-6 dependence of advanced malignant plasma cell dyscrasias

1992 • 82 citations

Activation of the Stress-Activated Protein Kinases by Multiple Hematopoietic Growth Factors With the Exception of Interleukin-4

1997 • 81 citations

Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells

2002 • 80 citations

Epstein-Barr Virus Latent Membrane Protein 2A Regulates c-Jun Protein through Extracellular Signal-Regulated Kinase

2002 • 80 citations

In vivo and in vitro inhibitory effect of α‐interferon on megakaryocyte colony growth in essential thrombocythaemia

1989 • 79 citations

The synergistic influence of human interferon-gamma and interferon-alpha on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro.

1985 • 79 citations

Molecular aspects of multiple myeloma

2002 • 76 citations

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

2000 • 76 citations

Sequence-Dependent Potentiation of Paclitaxel-Mediated Apoptosis in Human Leukemia Cells by Inhibitors of the Mitogen-Activated Protein Kinase Kinase/Mitogen-Activated Protein Kinase Pathway

2001 • 74 citations

The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways

2000 • 74 citations

Guanine-Nucleotide Exchange Protein C3G Activates JNK1 by a Ras-independent Mechanism

1998 • 73 citations

Activation of p38 Mitogen-activated Protein Kinase Is Required for Tumor Necrosis Factor-α-supported Proliferation of Leukemia and Lymphoma Cell Lines

2000 • 72 citations

Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

1994 • 69 citations

CrkL Mediates Ras-dependent Activation of the Raf/ERK Pathway through the Guanine Nucleotide Exchange Factor C3G in Hematopoietic Cells Stimulated with Erythropoietin or Interleukin-3

1999 • 64 citations

p38 MAPK-mediated activation of NF-κB by the RhoGEF domain of Bcr

2002 • 62 citations

Cellular Proliferation and Activation of NFκB Are Induced by Autocrine Production of Tumor Necrosis Factor α in the Human T Lymphoma Line HuT 78

1995 • 60 citations

Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation

2002 • 58 citations

Requirement of thrombopoietin-induced activation of ERK for megakaryocyte differentiation and of p38 for erythroid differentiation

2001 • 55 citations

Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

2002 • 53 citations

Complete Nucleotide Sequence, Expression, and Chromosomal Localisation of Human Mixed-Lineage Kinase 2

1995 • 52 citations

Targeted therapy for multiple myeloma

2001 • 48 citations

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells

2000 • 48 citations

Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2

1998 • 47 citations

Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway

2002 • 46 citations

Pharmacologically regulated cell therapy

2001 • 45 citations

Interferons

1995 • 43 citations

Mixed Lineage Kinase LZK Forms a Functional Signaling Complex with JIP-1, a Scaffold Protein of the c-Jun NH2-Terminal Kinase Pathway

2001 • 42 citations

Regulation of the c-jun Gene in p210 BCR-ABL Transformed Cells Corresponds With Activity of JNK, the c-jun N-Terminal Kinase

1998 • 41 citations

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1999 • 40 citations

Signaling networks and cell cycle control : the molecular basis of cancer and other diseases

2000 • 39 citations

Signaling Via the Interferon-α Receptor in Chronic Myelogenous Leukemia Cells

2002 • 34 citations

The Roles of Phosphatidylinositol 3-Kinase and Protein Kinase Cζ for Thrombopoietin-induced Mitogen-activated Protein Kinase Activation in Primary Murine Megakaryocytes

2001 • 33 citations

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

2000 • 30 citations

Myeloid Leukemia Cell Growth and Differentiation Are Independent of Mitogen-activated Protein Kinase ERK1/2 Activation

2000 • 30 citations

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells

1999 • 30 citations

Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells.

1999 • 27 citations

Proliferation of IL‐6‐independent multiple myeloma does not require the activity of extracellular signal‐regulated kinases (ERK1/2)

2002 • 26 citations

Stress and Inflammation

1998 • 23 citations

Activation of Extracellular Signal-Regulated Kinase through B-Cell Antigen Receptor in B-Cell Chronic Lymphocytic Leukemia

2002 • 22 citations

The Protein Kinase ERK3 Is Encoded by a Single Functional Gene: Genomic Analysis of the ERK3 Gene Family

2002 • 21 citations

Risk assessment of venous thromboembolism in medical patients

2000 • 21 citations

Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts.

2001 • 21 citations

Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell–derived hematopoietic cells to thrombopoietin in vitro

2002 • 19 citations

Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts

2001 • 17 citations

Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation

1998 • 14 citations

Influence of recombinant alpha and gamma interferons on the in vitro proliferation of myeloid and leukemic progenitors

1990 • 12 citations

Inhibition of MEK Induces Fas Expression and Apoptosis in Lymphomas Overexpressing Ras

2002 • 12 citations

Targeted therapy for multiple myeloma

2001 • 4 citations

Specific Inhibitors of p38 MAP Kinase

2003 • 3 citations