Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

1999 • 538 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

1997 • 504 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

1997 • 471 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

Acute promyelocytic leukemia: evolving therapeutic strategies

2002 • 399 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1997 • 387 citations

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

1999 • 373 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis.

2000 • 326 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

Ascorbic acid enhances arsenic trioxide–induced cytotoxicity in multiple myeloma cells

2001 • 275 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1997 • 274 citations

Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL

2000 • 242 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

1998 • 228 citations

Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

1998 • 228 citations

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

1999 • 226 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins

2000 • 195 citations

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

2001 • 194 citations

Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro

1999 • 188 citations

p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

1997 • 176 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Activation of the p38 Mitogen-activated Protein Kinase Mediates the Suppressive Effects of Type I Interferons and Transforming Growth Factor-β on Normal Hematopoiesis

2002 • 166 citations

Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid

2001 • 160 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-α in BCR-ABL-expressing Cells

2001 • 143 citations

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

1998 • 110 citations

Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1– and type 2–infected cells by a caspase-3–dependent mechanism involving Bcl-2 cleavage

2001 • 100 citations

The IRS-pathway operates distinctively from the stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors

1997 • 99 citations

Arsenic trioxide: Mechanisms of action

2002 • 98 citations

Cutting Edge: Activation of the p38 Mitogen-Activated Protein Kinase Signaling Pathway Mediates Cytokine-Induced Hemopoietic Suppression in Aplastic Anemia

2002 • 98 citations

The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of the CrkL Adaptor Protein

1997 • 98 citations

Treatment of acute promyelocytic leukemia with arsenic compounds: In vitro and in vivo studies

2001 • 90 citations

Arsenic compounds as anticancer agents

2001 • 90 citations

Treatment of acute promyelocytic leukemia with arsenic compounds: In vitro and in vivo studies

2001 • 86 citations

Arsenic trioxide cytotoxicity in steroid and chemotherapy-resistant myeloma cell lines: enhancement of apoptosis by manipulation of cellular redox state.

2002 • 80 citations

Expanding the use of arsenic trioxide: Leukemias and beyond

2002 • 80 citations

BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.

2000 • 77 citations

CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors

1999 • 58 citations

Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines

2001 • 45 citations

Multifaceted Approach to the Treatment of Bcr-Abl-Positive Leukemias

2002 • 37 citations

Recent advances in Philadelphia chromosome–positive malignancies: The potential role of arsenic trioxide

2002 • 29 citations

Arsenic trioxide: its role in acute promyelocytic leukemia and potential in other hematologic malignancies

2001 • 21 citations