Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1997 • 355 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Serine/threonine phosphorylation in cytokine signal transduction

2000 • 199 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.

1985 • 173 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1999 • 151 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Regulation of Raf-1 and Raf-1 Mutants by Ras-Dependent and Ras-Independent Mechanisms In Vitro

1995 • 140 citations

A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

1994 • 117 citations

Craf-1 protein kinase is essential for mouse development

1998 • 116 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway

1997 • 109 citations

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1998 • 100 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter.

1994 • 96 citations

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

1998 • 94 citations

Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes.

1996 • 87 citations

Synergism of v-myc and v-Ha-ras in the in Vitro Neoplastic Progression of Murine Lymphoid Cells

1986 • 78 citations

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

2000 • 76 citations

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1

1997 • 76 citations

Mechanisms regulating Raf‐1 activity in signal transduction pathways

1995 • 75 citations

Drosophila melanogaster homologs of the raf oncogene.

1987 • 70 citations

Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133

1995 • 68 citations

Mek1 Phosphorylation Site Mutants Activate Raf-1 in NIH 3T3 Cells

1996 • 53 citations

Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms.

1989 • 48 citations

Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells.

1996 • 38 citations

Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene.

1993 • 37 citations

A v-H-ras-Dependent Hemopoietic Tumor Model Involving Progression from a Clonal Stage of Transformation Competence to Autocrine Interleukin 3 Production

1989 • 37 citations

Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells.

1986 • 36 citations

Characterization of cis-Acting Sequences and trans-Acting Signals Regulating Early Growth Response 1 and c-fos Promoters Through the Granulocyte-Macrophage Colony-Stimulating Factor Receptor in BA/F3 Cells

1997 • 35 citations

Granulocyte-Macrophage Colony-stimulating Factor Induces the Transcriptional Activation of egr-1 through a Protein Kinase A-independent Signaling Pathway

1995 • 30 citations

Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line

1994 • 27 citations

Signal transduction by granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors.

1994 • 26 citations

Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation

1997 • 26 citations

Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation.

1997 • 25 citations

A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production.

1989 • 24 citations

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells

2000 • 24 citations

Characterization of proteins binding the 3′ regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells

1998 • 23 citations

A Swiss 3T3 Variant Cell Line Resistant to the Effects of Tumor Promoters Cannot Be Transformed by src

1990 • 23 citations

The molecular mechanism of action of granulocyte-macrophage colony-stimulating factor.

1996 • 19 citations

DIFFERENTIAL-EFFECTS OF VIRAL AND CELLULAR ONCOGENES ON THE GROWTH FACTOR-DEPENDENCY OF HEMATOPOIETIC-CELLS

1995 • 19 citations

Role of raf-1 Protein Kinase in IL-3 and GM-CSF-Mediated Signal Transduction

1990 • 16 citations

Regulation of interleukin 3 expression in normal and autocrine transformed hematopoietic cells (Review)

1997 • 15 citations

Mechanism of transcriptional activation of the immediate early gene Egr- 1 in response to PIXY321

1996 • 14 citations

The E1A transcriptional control region is efficiently activated in proliferating tissues of transgenic mice.

1994 • 10 citations

A Swiss 3T3 variant cell line resistant to the effects of tumor promoters cannot be transformed by src.

1990 • 8 citations

Cited By (0)

Loading...