Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

STATs and Gene Regulation

1997 • 3,927 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

1997 • 471 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways

1997 • 239 citations

Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

1998 • 228 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

Thrombin Induces Activation of p38 MAP Kinase in Human Platelets

1995 • 209 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini

1998 • 160 citations

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

1997 • 155 citations

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha.

1997 • 137 citations

The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of Insulin Receptor Substrate 2

1996 • 126 citations

Activation of a CrkL-Stat5 Signaling Complex by Type I Interferons

1999 • 126 citations

The IRS-pathway operates distinctively from the stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors

1997 • 99 citations

The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of the CrkL Adaptor Protein

1997 • 98 citations

Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells.

1994 • 85 citations

Application of Genomic DNA Affinity Chromatography Identifies Multiple Interferon-α-regulated Stat2 Complexes

1996 • 66 citations

The vav proto‐oncogene product (p95^vav) interacts with the Tyk‐2 protein tyrosine kinase

1997 • 33 citations