Pharmacological inhibitors of MAPK pathways

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

2001 • 772 citations

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1999 • 688 citations

Consensus Scoring: A Method for Obtaining Improved Hit Rates from Docking Databases of Three-Dimensional Structures into Proteins

1999 • 681 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

Inhibition of p38 MAP kinase as a therapeutic strategy

2000 • 463 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1997 • 387 citations

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

1999 • 348 citations

Development of anticancer drugs targeting the MAP kinase pathway

2000 • 322 citations

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

1998 • 309 citations

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

2000 • 303 citations

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

1998 • 291 citations

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1997 • 274 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery

1999 • 270 citations

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

1998 • 259 citations

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

2001 • 253 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.

2000 • 242 citations

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

1998 • 232 citations

Structural analysis of receptor tyrosine kinases

1999 • 215 citations

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

2001 • 203 citations

The discovery of potent cRaf1 kinase inhibitors

2000 • 202 citations

The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding

1998 • 200 citations

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

1999 • 194 citations

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

1999 • 153 citations

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

1999 • 150 citations

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

1998 • 136 citations

Resorcylic Acid Lactones. Naturally Occurring Potent and Sclective Inbibitors.

1999 • 109 citations

Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis

2001 • 98 citations

Molecular Basis for p38 Protein Kinase Inhibitor Specificity

1998 • 94 citations

Inhibitors of p38 MAP Kinase: Therapeutic Intervention in Cytokine-Mediated Diseases

1999 • 88 citations

New inhibitors of p38 kinase

2000 • 80 citations

Pharmacologic Inhibitors of MKK1 and MKK2

2001 • 64 citations

A Radicicol-Related Macrocyclic Nonaketide Compound, Antibiotic LL-Z1640-2, Inhibits the JNK/p38 Pathways in Signal-Specific Manner

1999 • 55 citations

Ro 09-2210 Exhibits Potent Anti-proliferative Effects on Activated T Cells by Selectively Blocking MKK Activity

1998 • 52 citations

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors

2000 • 51 citations

Synthesis and Structure–Activity Relationships of 3-Cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) Inhibitors

2000 • 49 citations

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

2001 • 40 citations

Kinetic mechanism and ATP‐binding site reactivity of p38γ MAP kinase

1999 • 29 citations