Pharmacologically regulated cell therapy

Embryonic Stem Cell Lines Derived from Human Blastocysts

1998 • 15,541 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

1998 • 2,762 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Bone Marrow as a Potential Source of Hepatic Oval Cells

1999 • 2,439 citations

Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

2000 • 1,859 citations

Dystrophin expression in the mdx mouse restored by stem cell transplantation

1999 • 1,817 citations

From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

2000 • 1,709 citations

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

1999 • 1,437 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Hematopoietic potential of stem cells isolated from murine skeletal muscle

1999 • 960 citations

Cell replacement therapies for central nervous system disorders

2000 • 948 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

Bone Marrow Transplantation

1994 • 597 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

2000 • 567 citations

Liver Transplantation

1989 • 557 citations

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

1998 • 522 citations

Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-L,2,3,6-Tetrahydropyridine (MPTP)

1992 • 499 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

Renal Transplantation

1994 • 428 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1998 • 422 citations

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

1994 • 415 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Liver Transplantation

1989 • 300 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

An antagonist peptide–EPO receptor complex suggests that receptor dimerization is not sufficient for activation

1998 • 216 citations

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen.

1993 • 215 citations

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

2001 • 200 citations

A ligand-reversible dimerization system for controlling protein–protein interactions

2000 • 187 citations

Synthetic activation of caspases: Artificial death switches

1998 • 186 citations

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

1995 • 154 citations

Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization

1996 • 149 citations

The Graft-Versus-Leukemia Effects of Allogeneic Cell Therapy

1999 • 130 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Intravenous Safety and Pharmacokinetics of a Novel Dimerizer Drug, AP1903, in Healthy Volunteers

2001 • 116 citations

Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny

2000 • 115 citations

Regulation of protein function through expression of chimaeric proteins

1994 • 111 citations

A proliferation switch for genetically modified cells

1997 • 108 citations

Improved Artificial Death Switches Based on Caspases and FADD

1999 • 106 citations

Structure and function of the glucocorticoid receptor

1993 • 100 citations

In vivo selection using a cell-growth switch

2000 • 97 citations

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen

1993 • 92 citations

A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal

1999 • 90 citations

Sustained Gene Expression in Retrovirally Transduced, Engrafting Human Hematopoietic Stem Cells and Their Lympho-Myeloid Progeny

1998 • 88 citations

Targeted expansion of genetically modified bone marrow cells

1998 • 76 citations

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

2001 • 66 citations

Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants.

1993 • 51 citations

Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization

2000 • 46 citations

Stimulating Cell Proliferation Through the Pharmacologic Activation of c-kit

1998 • 41 citations

Activation and Functional Analysis of Janus Kinase 2 in BA/F3 Cells Using the Coumermycin/Gyrase B System

1998 • 39 citations

Stem cell gene therapy, position effects and chromatin insulators

1997 • 38 citations

Development of a Novel Selective Amplifier Gene for Controllable Expansion of Transduced Hematopoietic Cells

1997 • 37 citations

Conditional Activation of Janus Kinase (JAK) Confers Factor Independence upon Interleukin-3-dependent Cells

1998 • 33 citations

Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.

1996 • 29 citations

A selective amplifier gene for tamoxifen-inducible expansion of hematopoietic cells

1999 • 28 citations

“Suicide” gene for the control of graft-versus-host disease

1998 • 24 citations

The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility

1998 • 22 citations

Structure-Activity Relationships in Coumermycins

1972 • 21 citations

A G-CSF Receptor–Gyrase B Fusion Gene: A New Type of Molecular Switch for Expansion of Genetically Modified Hematopoietic Cells

1999 • 18 citations

Hematopoietic stem cells with controllable tEpoR transgenes have a competitive advantage in bone marrow transplantation

2000 • 16 citations

Cellular Suicide Therapy of Malignant Disease

2000 • 13 citations

Cell Surface Tagging and a Suicide Mechanism in a Single Chimeric Human Protein

1999 • 10 citations

Deleted Work

1955 • 0 citations