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1993 • 2,280 citations

Chronic Myeloid Leukemia

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

2000 • 778 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

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1996 • 410 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

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Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

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A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis.

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Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

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Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

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Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

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Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

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Selective regulation ofBcl-X_Lby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

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