Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia.

1990 • 813 citations

Results of Treatment With Hyper-CVAD, a Dose-Intensive Regimen, in Adult Acute Lymphocytic Leukemia

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Chemotherapy Compared with Autologous or Allogeneic Bone Marrow Transplantation in the Management of Acute Myeloid Leukemia in First Remission

1998 • 628 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study

1996 • 423 citations

Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group.

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Improved outcome in adult B-cell acute lymphoblastic leukemia

1996 • 317 citations

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1992 • 306 citations

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

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Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1992 • 276 citations

Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

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Childhood monosomy 7: epidemiology, biology, and mechanistic implications

1995 • 269 citations

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

1999 • 255 citations

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

2000 • 247 citations

Management of Acute Myeloid Leukemia in Elderly Patients

1999 • 247 citations

The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

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Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

Isoprenylation is required for the processing of the lamin A precursor.

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The biology and treatment of acute lymphoblastic leukemia in adults

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Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.

1988 • 217 citations

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho

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Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia

1994 • 201 citations

Serine/threonine phosphorylation in cytokine signal transduction

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RASand Leukemia: From Basic Mechanisms to Gene-Directed Therapy

1999 • 193 citations

N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome

1993 • 187 citations

Ras Proteins: Recent Advances and New Functions

1999 • 140 citations

Protein prenylation: key to ras function and cancer intervention?

1992 • 134 citations

The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.

1994 • 121 citations

Comparison of potential markers of farnesyltransferase inhibition.

2000 • 121 citations

Nerve Growth Factor Stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities

1992 • 120 citations

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

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RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia

1990 • 108 citations

Farnesyl Protein Transferase Inhibitors and Other Therapies Targeting the Ras Signal Transduction Pathway

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ras Oncogene Activation and Occupational Exposures in Acute Myeloid Leukemia

1992 • 83 citations

A two-step timed sequential treatment for acute myelocytic leukemia

1989 • 80 citations

The molecular pathogenesis of treatment-induced (secondary) leukemias: foundations for treatment and prevention.

1997 • 72 citations

Has the prognosis of adult patients with acute myeloid leukemia improved over years? A single institution experience of 784 consecutive patients over a 16-year period

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Altered Formation of Topotecan-Stabilized Topoisomerase I-DNA Adducts in Human Leukemia Cells

1997 • 61 citations

Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons

1999 • 50 citations

An antibody which specifically recognizes prelamin A but not mature lamin A: application to detection of blocks in farnesylation-dependent protein processing.

1994 • 38 citations

Detection of Rare Mutant Alleles by Restriction Endonuclease-mediated Selective-PCR: Assay Design and Optimization

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The Hsp90 Chaperone Family

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Drug development train gathering steam

1996 • 19 citations

Expression of nuclear envelope lamins A and C in human myeloid leukemias.

1992 • 18 citations

SSCP detection of N-ras promoter mutations in AML patients.

1995 • 16 citations

Acute leukemia: Mechanisms of cell survival as targets for therapy (review)

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