Zinc Coordination Environments in Proteins as Redox Sensors and Signal Transducers

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2001 • 4,399 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Introduction to Protein Structure

2012 • 2,404 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

1996 • 1,857 citations

The neurobiology of zinc in health and disease

2005 • 1,756 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Zinc finger proteins: new insights into structural and functional diversity

2001 • 1,386 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

The Antioxidant Properties of Zinc

2000 • 1,264 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

Zinc requirements and the risks and benefits of zinc supplementation

2006 • 1,034 citations

Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators

2004 • 945 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

The physiological role of zinc as an antioxidant

1990 • 887 citations

[69] Overview of metallothionein

1991 • 793 citations

Superoxide in Apoptosis

1998 • 773 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Zinc coordination sphere in biochemical zinc sites.

2001 • 691 citations

Redox regulation of transcriptional activators

1996 • 690 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

The elusive function of metallothioneins

1998 • 676 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 606 citations

IAPs, RINGs and ubiquitylation

2005 • 591 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Metalloproteinases: Mediators of Pathology and Regeneration in the CNS

2005 • 557 citations

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

2002 • 547 citations

A Disulfide Relay System in the Intermembrane Space of Mitochondria that Mediates Protein Import

2005 • 535 citations

Chaperone Activity with a Redox Switch

1999 • 509 citations

Antioxidant effect of zinc in humans

2004 • 508 citations

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.

1994 • 489 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Control of zinc transfer between thionein, metallothionein, and zinc proteins

1998 • 463 citations

Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress

2004 • 445 citations

Metal and Redox Modulation of Cysteine Protein Function

2003 • 445 citations

Metallothioneins: Proteins in search of function

1985 • 445 citations

The role of zinc in caspase activation and apoptotic cell death.

2001 • 436 citations

Ebselen, a selenoorganic compound as glutathione peroxidase mimic

1993 • 414 citations

The Function of Zinc Metallothionein: A Link between Cellular Zinc and Redox State

2000 • 411 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

ADAMs: modulators of cell–cell and cell–matrix interactions

2003 • 406 citations

Modulation of mitochondrial function by endogenous Zn ²⁺ pools

2003 • 403 citations

Crosstalk between Nitric Oxide and Zinc Pathways to Neuronal Cell Death Involving Mitochondrial Dysfunction and p38-Activated K+ Channels

2004 • 390 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

Signaling events for metallothionein induction

2003 • 383 citations

Induction of Neuronal Apoptosis by Thiol Oxidation

2000 • 376 citations

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

2004 • 375 citations

Relationship Between the Occurrence of Cysteine in Proteins and the Complexity of Organisms

2000 • 373 citations

Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene.

1983 • 356 citations

Glutathione redox potential in response to differentiation and enzyme inducers

1999 • 351 citations

Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration

2003 • 346 citations

Refined crystal structure of Cd, Zn metallothionein at 2·0 Å resolution

1991 • 340 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Cellular zinc sensors: MTF-1 regulation of gene expression.

2001 • 323 citations

An Exploratory Study of Homeschooling in Kansas

1993 • 317 citations

Nuclear Receptor Minireview Series

2001 • 308 citations

A universal trend of amino acid gain and loss in protein evolution

2005 • 297 citations

Bridge over Troubled Waters

1999 • 294 citations

Thiol-Based Regulatory Switches

2003 • 294 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes.

1995 • 282 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9

1994 • 276 citations

Hypothesis: the role of reactive sulfur species in oxidative stress

2001 • 274 citations

Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria

2001 • 269 citations

Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling

2003 • 263 citations

A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8

2003 • 258 citations

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1

1998 • 257 citations

Zinc and Sulfur: A Critical Biological Partnership

2004 • 255 citations

Dimerization of cotton fiber cellulose synthase catalytic subunits occurs via oxidation of the zinc-binding domains

2002 • 252 citations

Zinc metallothionein imported into liver mitochondria modulates respiration

2001 • 250 citations

Structure of the Neurospora SET Domain Protein DIM-5, a Histone H3 Lysine Methyltransferase

2002 • 247 citations

Zinc Inhibition of Mitochondrial Aconitase and Its Importance in Citrate Metabolism of Prostate Epithelial Cells

1997 • 246 citations

Phosphotyrosyl protein phosphatases

1989 • 239 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Activity of Metal-Responsive Transcription Factor 1 by Toxic Heavy Metals and H₂O₂ In Vitro Is Modulated by Metallothionein

2003 • 235 citations

The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling

2007 • 231 citations

Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein

2000 • 231 citations

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody–drug conjugates

2005 • 229 citations

Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS

1995 • 228 citations

Role of Insulin-Induced Reactive Oxygen Species in the Insulin Signaling Pathway

2005 • 228 citations

Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels

1995 • 227 citations

Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein

2002 • 214 citations

Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein

2005 • 210 citations

Cellular Zinc and Redox States Converge in the Metallothionein/Thionein Pair

2003 • 200 citations

Superoxide-induced Stimulation of Protein Kinase C via Thiol Modification and Modulation of Zinc Content

2000 • 198 citations

Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes

2002 • 193 citations

A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells

2003 • 188 citations

The DNA Binding Activity of Metal Response Element-binding Transcription Factor-1 Is Activated in vivo and in Vitro by Zinc, but Not by Other Transition Metals

1998 • 186 citations

Zinc Supplementation Prevents Alcoholic Liver Injury in Mice through Attenuation of Oxidative Stress

2005 • 183 citations

Antioxidant Effects of Zinc Supplementation in Tunisians with Type 2 Diabetes Mellitus

2003 • 181 citations

The influence of zinc on apoptosis.

1995 • 176 citations

Zinc Binding and Redox Control of p53 Structure and Function

2001 • 176 citations

Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells

2000 • 174 citations

Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen

2002 • 172 citations

Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase

2002 • 169 citations

Metal Response Element (MRE)-Binding Transcription Factor-1 (MTF-1): Structure, Function, and Regulation

2001 • 166 citations

Protein Tyrosine Phosphatases as Targets of the Combined Insulinomimetic Effects of Zinc and Oxidants

2005 • 165 citations

Nitric oxide mediates intracytoplasmic and intranuclear zinc release

1997 • 163 citations

Nuclear localization of metallothionein during cell proliferation and differentiation.

2000 • 162 citations

Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.

1999 • 162 citations

Zinc Ions Inhibit the Qp Center of Bovine Heart Mitochondrial bc1 Complex by Blocking a Protonatable Group

1995 • 161 citations

A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells

1997 • 161 citations

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

1995 • 160 citations

Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn²⁺release

2003 • 157 citations

Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex

2000 • 155 citations

Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells

2006 • 155 citations

Antioxidant-Like Properties of Zinc in Activated Endothelial Cells

1999 • 152 citations

Intracellular free zinc and zinc buffering in human red blood cells

1991 • 151 citations

Activation of the Redox-Regulated Molecular Chaperone Hsp33—A Two-Step Mechanism

2001 • 148 citations

Zinc coordination environments in proteins determine zinc functions

2005 • 147 citations

Redox State Changes in Density-Dependent Regulation of Proliferation

1997 • 146 citations

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

1997 • 143 citations

Reactivity of Zinc Finger Cores: Analysis of Protein Packing and Electrostatic Screening

2001 • 143 citations

Direct Reaction of H2O2with Sulfhydryl Groups in HL-60 Cells: Zinc-Metallothionein and Other Sites

1996 • 139 citations

Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein

1996 • 138 citations

Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein

2001 • 136 citations

The small Tim proteins and the twin Cx3C motif

2003 • 135 citations

Target gene search for the metal-responsive transcription factor MTF-1

2001 • 135 citations

Selenium redox biochemistry of zinc–sulfur coordination sites in proteins and enzymes

1999 • 132 citations

Zinc transfer potentials of the α- and β-clusters of metallothionein are affected by domain interactions in the whole molecule

2000 • 130 citations

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

2000 • 127 citations

ZINC-mediated gene expression offers protection against HO-induced cytotoxicity

2004 • 126 citations

Betaine-Homocysteine Methyltransferase

2002 • 122 citations

Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases

2005 • 120 citations

Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide

2000 • 118 citations

Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function

2003 • 117 citations

Functional TIM10 Chaperone Assembly Is Redox-regulated in Vivo

2004 • 117 citations

Growth Inhibitory Factor Prevents Neurite Extension and the Death of Cortical Neurons Caused by High Oxygen Exposure through Hydroxyl Radical Scavenging

2002 • 116 citations

S-Nitrosothiols React Preferentially with Zinc Thiolate Clusters of Metallothionein III through Transnitrosation

2002 • 113 citations

Coordination dynamics of biological zinc “clusters” in metallothioneins and in the DNA-binding domain of the transcription factor Gal4

1997 • 112 citations

Chopped, trapped or tacked – protein translocation into the IMS of mitochondria

2005 • 109 citations

Changes in Rat Hepatic Gene Expression in Response to Zinc Deficiency as Assessed by DNA Arrays

2003 • 106 citations

Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts

2005 • 105 citations

Study of the interactions of cadmium and zinc ions with cellular calcium homoeostasis using 19F-NMR spectroscopy

1997 • 97 citations

The Role of Zinc in the Disulphide Stress-regulated Anti-sigma Factor RsrA from Streptomyces coelicolor

2003 • 97 citations

Metallothionein Disulfides Are Present in Metallothionein-overexpressing Transgenic Mouse Heart and Increase under Conditions of Oxidative Stress

2005 • 96 citations

Metal Complexes of Phosphoglucomutase in Vivo

1971 • 96 citations

Catalytic selenols couple the redox cycles of metallothionein and glutathione

2001 • 95 citations

Interaction of selenium compounds with zinc finger proteins involved in DNA repair

2004 • 95 citations

Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: Regulation of estrogen-dependent gene transcription

2005 • 94 citations

Studying zinc biology with fluorescence: ain’t we got fun?

2005 • 92 citations

Modeling the DNA Methylphosphotriester Repair Site in Escherichia coli Ada. Why Zinc and Four Cysteines?

1995 • 92 citations

Inhibition of the Catalytic Activity of Alcohol Dehydrogenase by Nitric Oxide Is Associated with S Nitrosylation and the Release of Zinc

1996 • 91 citations

Activation of Tumor Necrosis Factor-α-converting Enzyme-mediated Ectodomain Shedding by Nitric Oxide

2000 • 90 citations

Latent and Active Human Polymorphonuclear Leukocyte Collagenases

1983 • 87 citations

Ebselen, a Selenium-Containing Redox Drug, Releases Zinc from Metallothionein

1998 • 87 citations

The Role of Hot13p and Redox Chemistry in the Mitochondrial TIM22 Import Pathway

2004 • 87 citations

Control of Thiolate Nucleophilicity and Specificity in Zinc Metalloproteins by Hydrogen Bonding: Lessons from Model Compound Studies

2002 • 85 citations

Increased Frequency of Cysteine, Tyrosine, and Phenylalanine Residues Since the Last Universal Ancestor

2002 • 81 citations

Potential Drugs Against Cervical Cancer: Zinc-Ejecting Inhibitors of the Human Papillomavirus Type 16 E6 Oncoprotein

1999 • 81 citations

Selenium prevents diabetes-induced alterations in [Zn²⁺]_iand metallothionein level of rat heart via restoration of cell redox cycle

2005 • 80 citations

The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.

1996 • 79 citations

Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates

2003 • 77 citations

S-Nitrosation and Regulation of Inducible Nitric Oxide Synthase

2005 • 76 citations

Glutathiolation of Proteins by Glutathione DisulfideS-Oxide Derived from S-Nitrosoglutathione

2001 • 76 citations

Oxidants increase intracellular free Zn2+ concentration in rabbit ventricular myocytes

1997 • 76 citations

Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides

2002 • 75 citations

Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines

2005 • 75 citations

The ATP–metallothionein complex

1998 • 74 citations

Imbalance between pro-oxidant and pro-antioxidant functions of zinc in disease

2005 • 74 citations

Thionein can serve as a reducing agent for the methionine sulfoxide reductases

2006 • 74 citations

Redox-regulated molecular chaperones

2002 • 73 citations

On the Competition for Available Zinc

2004 • 73 citations

Preferential Oxidation of Zinc Finger 2 in Estrogen Receptor DNA-binding Domain Prevents Dimerization and, Hence, DNA Binding

2000 • 66 citations

Zinc Finger of Replication Protein A, a Non-DNA Binding Element, Regulates Its DNA Binding Activity through Redox

1999 • 66 citations

Assignment of the Zinc Ligands in RsrA, a Redox-Sensing ZAS Protein from Streptomyces coelicolor

2006 • 65 citations

Reduction-oxidation (redox) state regulation of extracellular matrix metalloproteinases and tissue inhibitors in cardiac normal and transformed fibroblast cells

1996 • 65 citations

Zinc-Bound Thiolate−Disulfide Exchange: A Strategy for Inhibiting Metallo-β-lactamases

2003 • 63 citations

Microglia induce neurotoxicity via intraneuronal Zn²⁺ release and a K⁺ current surge

2007 • 62 citations

Transient Peaks in Zinc and Metallothionein Levels during Differentiation of 3T3L1 Cells

1999 • 62 citations

Motexafin Gadolinium Disrupts Zinc Metabolism in Human Cancer Cell Lines

2005 • 62 citations

Zinc Transport and Metallothionein Secretion in the Intestinal Human Cell Line Caco-2

2000 • 60 citations

Oxidative dimerization in metallothionein is a result of intermolecular disulphide bonds between cysteines in the α-domain

2001 • 60 citations

Crystallographic location of two Zn2+-binding sites in the avian cytochrome bc1 complex

2000 • 59 citations

Zinc‐dependent dimerization of the folding catalyst, protein disulfide isomerase

2004 • 58 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 58 citations

Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein

2006 • 56 citations

A Novel Cysteine Cluster in Human Metal-responsive Transcription Factor 1 Is Required for Heavy Metal-induced Transcriptional Activation in Vivo

2004 • 55 citations

Redox Labile Site in a Zn₄ Cluster of Cu₄,Zn₄−Metallothionein-3

2003 • 55 citations

Nuclear trafficking of metallothionein requires oxidation of a cytosolic partner

2004 • 54 citations

Zinc Binding Stabilizes Mitochondrial Tim10 in a Reduced and Import-competent State Kinetically

2005 • 54 citations

Zn₇Metallothionein-3 and the Synaptic Vesicle Cycle: Interaction of Metallothionein-3 with the Small GTPase Rab3A

2005 • 53 citations

Imaging Zinc: Old and New Tools

2003 • 53 citations

DNA binding domain of GAL4 forms a binuclear metal ion complex

1990 • 52 citations

The Six Zinc Fingers of Metal-responsive Element Binding Transcription Factor-1 Form Stable and Quasi-ordered Structures with Relatively Small Differences in Zinc Affinities

2005 • 52 citations

Exploring the zinc proteome

2004 • 52 citations

A differential assay for the reduced and oxidized states of metallothionein and thionein

2004 • 51 citations

Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration

2004 • 49 citations

Identification of Genes Responsive to Intracellular Zinc Depletion in the Human Colon Adenocarcinoma Cell Line HT-29

2004 • 48 citations

“Zn-Link”: A Metal-Sharing Interface that Organizes the Quaternary Structure and Catalytic Site of the Endoribonuclease, RNase E

2005 • 48 citations

Covalent Sequestration of Melphalan by Metallothionein and Selective Alkylation of Cysteines

1995 • 48 citations

Alcohol-Induced Myocardial Fibrosis in Metallothionein-Null Mice

2005 • 47 citations

The ATP/Metallothionein Interaction: NMR and STM

2002 • 45 citations

Dietary zinc modulates gene expression in murine thymus: Results from a comprehensive differential display screening

2003 • 44 citations

A decrease in intracellular zinc level precedes the detection of early indicators of apoptosis in HL-60 cells.

2001 • 42 citations

A Binding Site for Chlorambucil on Metallothionein

1996 • 41 citations

The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress

2005 • 41 citations

Nuclear trafficking of metallothionein: possible mechanisms and current knowledge.

2000 • 40 citations

Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an example

2001 • 39 citations

Regulation of Metallothionein Gene Expression and Secretion in Rat Adipocytes Differentiated from Preadipocytes in Primary Culture

2000 • 38 citations

Reconstitution of Apo-Superoxide Dismutase by Nitric Oxide-Induced Copper Transfer from Metallothioneins

2000 • 38 citations

Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts

2000 • 38 citations

Enzymatic Oxidation of Disulfides and Thiolsulfinates by both Rabbit Liver Microsomes and a Reconstituted System with Purified Cytochrome P-450

1978 • 37 citations

Patterns in the quinary structures of proteins. Plasticity and inequivalence of individual molecules in helical arrays of sickle cell hemoglobin and tubulin

1980 • 36 citations

Regulation of the Monomer-Dimer Equilibrium in Inducible Nitric-oxide Synthase by Nitric Oxide

2006 • 36 citations

Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel

1997 • 36 citations

Redox-regulated cochaperone activity of the human DnaJ homolog Hdj2

2005 • 31 citations

Experimental determination and calculations of redox potential descriptors of compounds directed against retroviral zinc fingers: Implications for rational drug design

2001 • 31 citations

Oxidation of Zinc Finger Cysteines to Thiolsulfinate

1998 • 30 citations

Catalytic Oxidation of Zinc/Sulfur Coordination Sites in Proteins by Selenium Compounds

2001 • 30 citations

Nutrient-gene interactions: a single nutrient and hundreds of target genes

2004 • 28 citations

The RING-H2–finger protein APC11 as a target of hydrogen peroxide

2004 • 28 citations

Reactivity of zinc finger cysteines: Chemical modifications within labile zinc fingers in estrogen receptor

2005 • 27 citations

Effect of redox conditions on the DNA-binding efficiency of the retinoic acid receptor zinc-finger

1998 • 27 citations

DNA damage-induced [Zn²⁺]_itransients: correlation with cell cycle arrest and apoptosis in lymphoma cells

2002 • 25 citations

trans Repression of the Human Metallothionein IIA Gene Promoter by PZ120, a Novel 120-Kilodalton Zinc Finger Protein

1999 • 24 citations

Effects of increased cellular zinc levels on gene and protein expression in HT-29 cells

2005 • 24 citations

Energy-dependent nuclear binding dictates metallothionein localization

2000 • 24 citations

Location and Functional Significance of Retinol-binding Sites on the Serine/Threonine Kinase, c-Raf

2005 • 23 citations

Redox Control of Zinc Finger Proteins: Mechanisms and Role in Gene Regulation

2001 • 18 citations

Oxidation of Zn(N2S2) complexes to disulfonates: relevance to zinc-finger oxidation under oxidative stress

2005 • 17 citations

A Dynamic Zinc Redox Switch

2004 • 17 citations

A zinc‐finger like metal binding site in the nucleosome

2007 • 16 citations

Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts

2000 • 12 citations

The activation mechanism of human porphobilinogen synthase by 2-mercaptoethanol: intrasubunit transfer of a reserve zinc ion and coordination with three cysteines in the active center

2005 • 8 citations

Ap4A is not an efficient Zn(II) binding agent. A concerted potentiometric, calorimetric and NMR study

2007 • 6 citations