Metal and Redox Modulation of Cysteine Protein Function

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

X-ray Crystal Structure of the Fe-Only Hydrogenase (CpI) from Clostridium pasteurianum to 1.8 Angstrom Resolution

1998 • 1,814 citations

OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

1993 • 1,377 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Metallothionein: the multipurpose protein

2002 • 1,262 citations

Biochemistry of metallothionein

1988 • 1,222 citations

The ZIP family of metal transporters

2000 • 1,129 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

Regulation of metallothionein gene expression by oxidative stress and metal ions

2000 • 810 citations

Structural Basis for the Inhibition of Caspase-3 by XIAP

2001 • 763 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Metals and neuroscience

2000 • 724 citations

Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function

2003 • 720 citations

The elusive function of metallothioneins

1998 • 676 citations

Protein Oxidation in Aging and Age‐Related Diseases

2001 • 656 citations

Comprehensive biological catalysis

1998 • 647 citations

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 • 610 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Redox‐dependent signal transduction

2000 • 558 citations

Peroxiredoxins

2002 • 555 citations

Structural Basis of the Redox Switch in the OxyR Transcription Factor

2001 • 544 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

2001 • 535 citations

Crystal Structure of a Carbon Monoxide Dehydrogenase Reveals a [Ni-4Fe-5S] Cluster

2001 • 522 citations

Eukaryotic zinc transporters and their regulation.

2001 • 513 citations

Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

2000 • 498 citations

Vitamins for Chronic Disease Prevention in Adults

2002 • 497 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

2001 • 473 citations

Control of zinc transfer between thionein, metallothionein, and zinc proteins

1998 • 463 citations

Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

2001 • 441 citations

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

1995 • 430 citations

Antioxidant enzyme levels in cancer.

1997 • 396 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

S-Nitrosylation of mitochondrial caspases

2001 • 365 citations

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1998 • 360 citations

Refined crystal structure of Cd, Zn metallothionein at 2·0 Å resolution

1991 • 340 citations

The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver.

1982 • 336 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

1983 • 323 citations

Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum.

1992 • 318 citations

Nitric Oxide-induced S-Glutathionylation and Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase

1999 • 316 citations

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7Å resolution

2000 • 296 citations

Reactive Sulfur Species: An Emerging Concept in Oxidative Stress

2002 • 294 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

Hypothesis: the role of reactive sulfur species in oxidative stress

2001 • 274 citations

Crystal Structure of Cd,Zn Metallothionein

1986 • 270 citations

ZnT7, a Novel Mammalian Zinc Transporter, Accumulates Zinc in the Golgi Apparatus

2003 • 267 citations

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

1982 • 255 citations

Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic β Cells

2002 • 254 citations

Protein‐sulfenic acid stabilization and function in enzyme catalysis and gene regulation

1993 • 250 citations

Crystal Structure of Cobalt-Containing Nitrile Hydratase

2001 • 242 citations

Free radical metabolites of L-cysteine oxidation.

1984 • 241 citations

Thioredoxin reductase

2000 • 237 citations

Mammalian Zinc Transporters ,

1998 • 226 citations

Structural Studies of the Carbon Monoxide Complex of [NiFe]hydrogenase fromDesulfovibriovulgarisMiyazaki F: Suggestion for the Initial Activation Site for Dihydrogen

2002 • 225 citations

Zinc and Cadmium Can Promote Rapid Nuclear Translocation of Metal Response Element-binding Transcription Factor-1

2000 • 218 citations

Redox metals and neu rodegenerative disease

1999 • 218 citations

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2

2002 • 215 citations

Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6

2002 • 212 citations

Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.

2002 • 212 citations

Oxidative protein folding in bacteria

2002 • 211 citations

Radical Mechanisms of Enzymatic Catalysis

2001 • 211 citations

Great Metalloclusters in Enzymology

2002 • 209 citations

Multiple roles of cysteine in biocatalysis

2003 • 207 citations

Cellular Zinc and Redox States Converge in the Metallothionein/Thionein Pair

2003 • 200 citations

Physical and Functional Sensitivity of Zinc Finger Transcription Factors to Redox Change

1996 • 192 citations

Zinc Binding and Redox Control of p53 Structure and Function

2001 • 176 citations

S-Nitrosylation and S-Glutathiolation of Protein Sulfhydryls byS-Nitroso Glutathione

1999 • 174 citations

Nitric Oxide Inhibits c-Jun DNA Binding by Specifically TargetedS-Glutathionylation

1999 • 156 citations

Functional domains of the heavy metal-responsive transcription regulator MTF-1

1995 • 155 citations

How to Flip the (Redox) Switch

2002 • 153 citations

Suppression of neuronal apoptosis by S-nitrosylation of caspases

1997 • 153 citations

The Free Radical of the Anaerobic Ribonucleotide Reductase from Escherichia coli Is at Glycine 681

1996 • 151 citations

Oxidants Painting the Cysteine Chapel

2002 • 150 citations

Zinc Homeostasis-regulating Proteins: New Drug Targets for Triggering Cell Fate

2003 • 139 citations

Structural, redox, and mechanistic parameters for cysteine-sulfenic acid function in catalysis and regulation

2001 • 137 citations

Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro

2003 • 136 citations

Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein

2001 • 136 citations

Determination of Metallothionein at the Femtomole Level by Constant Current Stripping Chronopotentiometry

2001 • 136 citations

Oxidation of Zinc Finger Transcription Factors: Physiological Consequences

2001 • 136 citations

Aging and oxidation of reactive protein sulfhydryls

2001 • 135 citations

Synthesis, Structure, and Reactions of a Sulfenic Acid Bearing a Novel Bowl-Type Substituent: The First Synthesis of a Stable Sulfenic Acid by Direct Oxidation of a Thiol

1997 • 135 citations

Crystal Structure of the All-Ferrous [4Fe-4S]⁰ Form of the Nitrogenase Iron Protein from Azotobacter vinelandii^,

2000 • 134 citations

Oxidant-Induced S-Glutathiolation Inactivates Protein Kinase C-α (PKC-α): A Potential Mechanism of PKC Isozyme Regulation

2000 • 134 citations

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

2000 • 134 citations

Selenium redox biochemistry of zinc–sulfur coordination sites in proteins and enzymes

1999 • 132 citations

Products of metal exchange reactions of metallothionein

1985 • 131 citations

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

1997 • 131 citations

Reversible Activation of Mouse Metal Response Element-Binding Transcription Factor 1 DNA Binding Involves Zinc Interaction with the Zinc Finger Domain

1997 • 127 citations

Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

1994 • 127 citations

Conversion of a Peroxiredoxin into a Disulfide Reductase by a Triplet Repeat Expansion

2001 • 125 citations

Inhibition of Cathepsin K by Nitric Oxide Donors: Evidence for the Formation of Mixed Disulfides and a Sulfenic Acid

1999 • 122 citations

Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue

2000 • 118 citations

Going malignant: the hypoxia‐cancer connection in the prostate

2002 • 118 citations

Coordination dynamics of biological zinc “clusters” in metallothioneins and in the DNA-binding domain of the transcription factor Gal4

1997 • 112 citations

Characterization of an inhibitory metal binding site in carboxypeptidase A

1991 • 111 citations

The Molecular Mechanism of Lead Inhibition of Human Porphobilinogen Synthase

2001 • 110 citations

Vitamins for Chronic Disease Prevention in Adults

2002 • 108 citations

Benefits and Risks of Deferiprone in Iron Overload in Thalassaemia and Other Conditions

2003 • 105 citations

Trace Element Medicine and Chelation Therapy

1995 • 101 citations

Carboxypeptidase A: mechanism of zinc inhibition

1989 • 98 citations

Discussion

1998 • 96 citations

Catalytic selenols couple the redox cycles of metallothionein and glutathione

2001 • 95 citations

Regulation of Caspases by Nitric Oxide

2002 • 93 citations

Regulatory roles of thioredoxin in oxidative stress-induced cellular responses

2001 • 93 citations

Inhibition of the Catalytic Activity of Alcohol Dehydrogenase by Nitric Oxide Is Associated with S Nitrosylation and the Release of Zinc

1996 • 91 citations

SAG/ROC/Rbx/Hrt, a Zinc RING Finger Gene Family: Molecular Cloning, Biochemical Properties, and Biological Functions

2001 • 89 citations

Ebselen, a Selenium-Containing Redox Drug, Releases Zinc from Metallothionein

1998 • 87 citations

Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide

1999 • 84 citations

Inhibition of carboxypeptidase A by excess zinc: analysis of the structural determinants by X‐ray crystallography

1997 • 83 citations

A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated τ of Alzheimer’s disease

2003 • 82 citations

Direct Evidence for Intra- and Intermolecular Disulfide Bond Formation in the Human Glucocorticoid Receptor

1989 • 80 citations

Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance.

2002 • 79 citations

Structural and Functional Heterogeneity among the Zinc Fingers of Human MRE-Binding Transcription Factor-1

1998 • 76 citations

Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides

2002 • 75 citations

Use of hypoxia-directed drugs in the therapy of solid tumors.

1992 • 74 citations

The ATP–metallothionein complex

1998 • 74 citations

Sulfur-centered reactive intermediates derived from the oxidation of sulfur compounds of biological interest

2001 • 69 citations

The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators

2002 • 67 citations

Protection by Organotellurium Compounds against Peroxynitrite-Mediated Oxidation and Nitration Reactions

1998 • 66 citations

Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus 1 1Edited by R. Huber

1999 • 65 citations

X-ray structure of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis

1999 • 62 citations

Zinc Ejection as a New Rationale for the Use of Cystamine and Related Disulfide-Containing Antiviral Agents in the Treatment of AIDS

1997 • 59 citations

Responses to Peroxynitrite in Yeast: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) as a Sensitive Intracellular Target for Nitration and Enhancement of Chaperone Expression and Ubiquitination

2000 • 59 citations

Synthesis of a Stable Sulfenic Acid by Oxidation of a Sterically Hindered Thiol (Thiophenetriptycene-8-thiol)¹ and Its Characterization

1996 • 59 citations

Heavy metal-mediated activation of the rat Cu/Zn superoxide dismutase gene via a metal-responsive element

1999 • 58 citations

Redox catalysts as sensitisers towards oxidative stress

2003 • 52 citations

Effects of N-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses

1998 • 52 citations

Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis.

1998 • 51 citations

Enzymology of mitomycin C metabolic activation in tumour tissue

1996 • 48 citations

Cysteinyl and Substrate Radical Formation in Active Site Mutant E441Q of Escherichia coli Class I Ribonucleotide Reductase

1998 • 48 citations

Untitled

2002 • 48 citations

Putative Zinc-sensing Zinc Fingers of Metal-response Element-binding Transcription Factor-1 Stabilize a Metal-dependent Chromatin Complex on the Endogenous Metallothionein-I Promoter

2003 • 47 citations

In vivo measurement of tumor redox environment using EPR spectroscopy

2002 • 47 citations

The Structure of Calcium-Free Human m-Calpain Implications for Calcium Activation and Function

2001 • 44 citations

Essential viral and cellular zinc and iron containing metalloproteins as targets for novel antiviral and anticancer agents: implications for prevention and therapy of viral diseases and cancer.

2001 • 44 citations

Oxidation of biological thiols by highly reactive disulfide-S-oxides.

2002 • 43 citations

The atomic-resolution structure of a novel bacterial esterase

2000 • 41 citations

Electrochemistry of chalcogen compounds: prediction of antioxidant activity.

2001 • 39 citations

Electrochemical characterization of metallothionein metal-mercaptide complexes: Application of cyclic voltammetry to investigation of metalloproteins

1988 • 38 citations

The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease

1999 • 38 citations

Inhibition of Protein Tyrosine Phosphatases by Low-Molecular-Weight S-Nitrosothiols and S-Nitrosylated Human Serum Albumin

2000 • 35 citations

Environmental Stressors in Health and Disease

2001 • 35 citations

Redox Sensor Function of Metallothioneins

2002 • 35 citations

Redox Control of Zinc Finger Proteins

2002 • 35 citations

Enhancement of S-Nitrosylation in Glycosylated Hemoglobin

2000 • 34 citations

Electrochemical, in vitro and cell culture analysis of integrated redox catalysts: implications for cancer therapy

2003 • 34 citations

Presentation of Nitric Oxide Regulates Monocyte Survival through Effects on Caspase-9 and Caspase-3 Activation

2003 • 34 citations

Conformational Heterogeneity in the C-terminal Zinc Fingers of Human MTF-1

2001 • 33 citations

A novel iron chelator that does not induce HIF-1 activity

2002 • 32 citations

Nonidentical alkylation sites in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

1975 • 32 citations

Structural Characterization of the Cysteine-rich Domain of TFIIH p44 Subunit

2000 • 32 citations

Spectroscopic Properties of Metallothionein

2023 • 32 citations

Treatment and management of Wilson's disease

1999 • 32 citations

Experimental determination and calculations of redox potential descriptors of compounds directed against retroviral zinc fingers: Implications for rational drug design

2001 • 31 citations

A review of vitamins A, C, and E and their relationship to cardiovascular disease.

1998 • 30 citations

Crystal Structure of Carboxypeptidase A Complexed with <scp>d</scp>-Cysteine at 1.75 Å − Inhibitor-Induced Conformational Changes^,

2000 • 26 citations

Metal-Catalyzed Oxidation of Phenylalanine-Sensitive 3-Deoxy- <scp>d</scp> - arabino -Heptulosonate-7-Phosphate Synthase from Escherichia coli : Inactivation and Destabilization by Oxidation of Active-Site Cysteines

1999 • 25 citations

Electrochemical study of metallothioneins using cyclic voltammetry

1998 • 24 citations

Peroxides as oxidative enzyme inhibitors: Mechanism-based inhibition of a cysteine protease by an amino acid ozonide

1999 • 22 citations

New Inhibitors of Iron-Containing Nitrile Hydratases

2001 • 22 citations

In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites

2003 • 20 citations

Redox Control of Zinc Finger Proteins: Mechanisms and Role in Gene Regulation

2001 • 18 citations

Protein <font>S</font>-Thiolation, <font>S</font>-Nitrosylation, and Irreversible Sulfhydryl Oxidation: Roles in Redox Regulation

2003 • 17 citations

Synthesis of highly reactive organosulfur compounds

2002 • 17 citations

Metallothionein I reduction of cytochrome c

1993 • 15 citations

Conceptual and practical advances in the measurement and clinical management of lead toxicity.

1993 • 14 citations

Rabbit muscle GAPDH: non‐phosphorylating dehydrogenase activity induced by hydrogen peroxide

1997 • 14 citations

Disulfiram revisited

2000 • 13 citations

Electrochemical characterization of metallothionein metal—mercaptide complexes: application of cyclic voltammetry to investigation of metalloproteins

1988 • 12 citations

Bioinorganic Chemistry

1991 • 10 citations

Zinc Inhibition of Caspase-3 Activation Does Not Protect HeLa Cells from Apoptotic Cell Death

2001 • 9 citations

Effect of diet and disulfiram on acetaldehyde blood levels after ethanol in UChA and UChB rats

1993 • 8 citations

Effects of zinc on macromolecular synthesis and nuclear division during the yeast to mycelium transition in Sporothrix schenckii

1989 • 6 citations

ChemInform Abstract: Synthesis of a Stable Sulfenic Acid by Oxidation of a Sterically Hindered Thiol (Thiophenetriptycene‐8‐thiol) and Its Characterization.

1997 • 3 citations

Ternary complexes of liver alcohol dehydrogenase

2001 • 3 citations