Zinc coordination environments in proteins determine zinc functions

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron

2000 • 834 citations

Zinc coordination sphere in biochemical zinc sites.

2001 • 691 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 606 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Eukaryotic zinc transporters and their regulation.

2001 • 513 citations

Chaperone Activity with a Redox Switch

1999 • 509 citations

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

2002 • 480 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

Cysteine regulation of protein function – as exemplified by NMDA-receptor modulation

2002 • 365 citations

Cellular zinc sensors: MTF-1 regulation of gene expression.

2001 • 323 citations

The Importance of Chemical “Speciation” in Environmental Processes

1986 • 288 citations

Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9

1994 • 276 citations

Advances in the structure and chemistry of metallothioneins

2002 • 274 citations

Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling

2003 • 263 citations

Zinc and Sulfur: A Critical Biological Partnership

2004 • 255 citations

Metal Binding and Catalytic Activity in Bovine Carbonic Anhydrase

1962 • 255 citations

Zinc metallothionein imported into liver mitochondria modulates respiration

2001 • 250 citations

Insulin-like Effect of Zinc on Adipocytes

1980 • 205 citations

Cellular Zinc and Redox States Converge in the Metallothionein/Thionein Pair

2003 • 200 citations

Zinc Fingers in Caenorhabditis elegans : Finding Families and Probing Pathways

1998 • 200 citations

A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells

2003 • 188 citations

Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen

2002 • 172 citations

Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase

2002 • 169 citations

Nuclear localization of metallothionein during cell proliferation and differentiation.

2000 • 162 citations

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

1995 • 160 citations

Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein

2001 • 136 citations

Selenium redox biochemistry of zinc–sulfur coordination sites in proteins and enzymes

1999 • 132 citations

Betaine-Homocysteine Methyltransferase

2002 • 122 citations

S-Nitrosothiols React Preferentially with Zinc Thiolate Clusters of Metallothionein III through Transnitrosation

2002 • 113 citations

Coordination dynamics of biological zinc “clusters” in metallothioneins and in the DNA-binding domain of the transcription factor Gal4

1997 • 112 citations

The importance of chemical “speciation” in environmental processes

1987 • 98 citations

The Role of Zinc in the Disulphide Stress-regulated Anti-sigma Factor RsrA from Streptomyces coelicolor

2003 • 97 citations

ZZ Domain of CBP: an Unusual Zinc Finger Fold in a Protein Interaction Module

2004 • 87 citations

Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada

1993 • 82 citations

Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition

2003 • 76 citations

Zinc Finger of Replication Protein A, a Non-DNA Binding Element, Regulates Its DNA Binding Activity through Redox

1999 • 66 citations

Imaging Zinc: Old and New Tools

2003 • 53 citations

Structural and Functional Characterization of the Zn(II) Site in Dimethylargininase-1 (DDAH-1) from Bovine Brain

2001 • 52 citations

Exploring the zinc proteome

2004 • 52 citations

A differential assay for the reduced and oxidized states of metallothionein and thionein

2004 • 51 citations

The ATP/Metallothionein Interaction: NMR and STM

2002 • 45 citations

Dietary zinc modulates gene expression in murine thymus: Results from a comprehensive differential display screening

2003 • 44 citations

Insulin-like effect of zinc on adipocytes

1980 • 40 citations

Nuclear trafficking of metallothionein: possible mechanisms and current knowledge.

2000 • 40 citations

Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an example

2001 • 39 citations

Regulation of Metallothionein Gene Expression and Secretion in Rat Adipocytes Differentiated from Preadipocytes in Primary Culture

2000 • 38 citations

The RING-H2–finger protein APC11 as a target of hydrogen peroxide

2004 • 28 citations

Nutrient-gene interactions: a single nutrient and hundreds of target genes

2004 • 28 citations

Redox Control of Zinc Finger Proteins: Mechanisms and Role in Gene Regulation

2001 • 18 citations

Does the Coordination Environment Determine the Reactivity of Metals in Enzymes?

1986 • 1 citations