Induction of Neuronal Apoptosis by Thiol Oxidation

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Regulation of metallothionein gene expression by oxidative stress and metal ions

2000 • 810 citations

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

1989 • 733 citations

Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current

1997 • 574 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis

1997 • 551 citations

Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.

1990 • 509 citations

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

1993 • 490 citations

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.

1985 • 489 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Control of zinc transfer between thionein, metallothionein, and zinc proteins

1998 • 463 citations

Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry

1997 • 463 citations

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1999 • 418 citations

Preferential Zn ²⁺ influx through Ca ²⁺ -permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

1999 • 408 citations

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

1989 • 390 citations

Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD⁺and Inhibition of Glycolysis

2000 • 354 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9

1994 • 276 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals

1999 • 270 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein

2000 • 231 citations

Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels

1995 • 227 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

Oxygen free radicals regulate NMDA receptor function via a redox modulatory site

1990 • 205 citations

Ceramide Induces Apoptosis in Cultured Mesencephalic Neurons

1996 • 191 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

1994 • 177 citations

Zn²⁺ entry produces oxidative neuronal necrosis in cortical cell cultures

1999 • 177 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: A review

1999 • 169 citations

Nitric oxide mediates intracytoplasmic and intranuclear zinc release

1997 • 163 citations

Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.

1999 • 162 citations

A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells

1997 • 161 citations

Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex

2000 • 155 citations

Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

1997 • 142 citations

Induction of an Immediate Early Gene egr‐1 by Zinc Through Extracellular Signal‐Regulated Kinase Activation in Cortical Culture

1999 • 127 citations

Nitric oxide induces Zn2+ release from metallothionein by destroying zinc–sulphur clusters without concomitant formation of S-nitrosothiol

1999 • 123 citations

Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons

1999 • 118 citations

Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya

1998 • 116 citations

A New Zn2+-stimulated Sphingomyelinase in Fetal Bovine Serum

1989 • 111 citations

Methylmalonate toxicity in primary neuronal cultures

1998 • 110 citations

Accumulation of extracellular glutamate and neuronal death in astrocyte‐poor cortical cultures exposed to glutamine

1991 • 96 citations

Stability constant for the zinc-dithiothreitol complex

1972 • 92 citations

Measurement of free Zn2+ ion concentration with the fluorescent probe mag-fura-2 (furaptra)

1993 • 92 citations

High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations

1999 • 89 citations

Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture

1998 • 88 citations

The effect of Zn2+ ions on mitochondrial electron transport

1974 • 85 citations

Calcium‐Sensitive Fluorescent Dyes Can Report Increases in Intracellular Free Zinc Concentration in Cultured Forebrain Neurons

1998 • 82 citations

Actions of sulfhydryl reagents on single ryanodine receptor Ca(2+)-release channels from sheep myocardium

1997 • 78 citations

NMDA Receptor‐Mediated Neurotoxicity: A Paradoxical Requirement for Extracellular Mg²⁺ in Na⁺/Ca²⁺‐Free Solutions in Rat Cortical Neurons In Vitro

1997 • 77 citations

Astrocytes Are More Resistant Than Neurons to the Cytotoxic Effects of Increased [Zn2+]i

2000 • 76 citations

Nitric oxide induces Zn2+ release from metallothionein by destroying zinc‒sulphur clusters without concomitant formation of S-nitrosothiol

1999 • 70 citations

TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro

1998 • 68 citations

Measurement of Intracellular Free Zinc in Living Neurons

1997 • 67 citations

Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus

1998 • 63 citations

Effect of p53 Protein Redox States on Binding to Supercoiled and Linear DNA

1999 • 46 citations

Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example

1989 • 42 citations

Induction by Synaptic Zinc of Heat Shock Protein-70 in Hippocampus after Kainate Seizures

2000 • 37 citations

Inhibition of poly(ADP‐ribose) synthetase (PARS) and protection against peroxynitrite‐induced cytotoxicity by zinc chelation

1999 • 36 citations

Involvement of Intracellular Labile Zinc in Suppression of DEVD-Caspase Activity in Human Neuroblastoma Cells

2000 • 33 citations

Chapter 5 Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial?

1998 • 31 citations

Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells.

1999 • 23 citations