Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

Chaperone Activity with a Redox Switch

1999 • 509 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.

1993 • 275 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

1994 • 202 citations

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

1996 • 198 citations

Superoxide-induced Stimulation of Protein Kinase C via Thiol Modification and Modulation of Zinc Content

2000 • 198 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 194 citations

Redox Switch of Hsp33 Has a Novel Zinc-binding Motif

2000 • 189 citations

Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C

1993 • 184 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Mass Spectrometry Unravels Disulfide Bond Formation as the Mechanism That Activates a Molecular Chaperone

2000 • 94 citations

Mercurial-promoted Zn2+ release from Escherichia coli aspartate transcarbamoylase.

1984 • 90 citations

Retinoids as ligands and coactivators of protein kinase C alpha

2000 • 86 citations

The Cysteine-Rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid Receptors

2000 • 80 citations

Protein kinase C and phospholipase C: bilayer interactions and regulation

1997 • 70 citations

The Distribution of Zinc Selenite and Expression of Metallothionein-III mRNA in the Spinal Cord and Dorsal Root Ganglia of the Rat Suggest a Role for Zinc in Sensory Transmission

1999 • 51 citations