Protein Tyrosine Phosphatases as Targets of the Combined Insulinomimetic Effects of Zinc and Oxidants

Protein Tyrosine Phosphatases in the Human Genome

2004 • 1,842 citations

Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes

2004 • 1,017 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

Zinc, Insulin and Diabetes

1998 • 718 citations

Protein tyrosine phosphatase 1B inhibitors for diabetes

2002 • 629 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Functions of zinc in signaling, proliferation and differentiation of mammalian cells.

2001 • 596 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade

2001 • 511 citations

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

2004 • 509 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.

1985 • 489 citations

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

1996 • 424 citations

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

2002 • 407 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

Chemistry and Biochemistry of Type 2 Diabetes

2004 • 319 citations

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

2004 • 277 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Zinc Has an Insulin-Like Effect on Glucose Transport Mediated by Phosphoinositol-3-Kinase and Akt in 3T3-L1 Fibroblasts and Adipocytes

2001 • 272 citations

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.

1998 • 265 citations

Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling

2003 • 263 citations

Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin

1997 • 252 citations

Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status

2004 • 224 citations

Insulin-like Effect of Zinc on Adipocytes

1980 • 205 citations

Coordinated action of protein tyrosine phosphatases in insulin signal transduction

2002 • 187 citations

Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells

2000 • 174 citations

Dietary Zinc Supplementation Attenuates Hyperglycemia in db/db Mice

2001 • 172 citations

Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice

1998 • 166 citations

Obesity and hyperleptinemia in metallothionein (-I and -II) null mice

1998 • 165 citations

Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action

2004 • 160 citations

Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.

1993 • 156 citations

Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.

1987 • 156 citations

The mechanism of the insulin-like effects of ionic zinc.

1982 • 156 citations

Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2

1997 • 156 citations

Direct Reaction of H2O2with Sulfhydryl Groups in HL-60 Cells: Zinc-Metallothionein and Other Sites

1996 • 139 citations

Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein

2001 • 136 citations

Insulinlike Effects of Zinc Ion in Vitro and in Vivo: Preferential Effects on Desensitized Adipocytes and Induction of Normoglycemia in Streptozocin-Induced Rats

1992 • 135 citations

Selenium redox biochemistry of zinc–sulfur coordination sites in proteins and enzymes

1999 • 132 citations

The reduced secretion of, and sensitivity to insulin in zinc-deficient rats

1966 • 126 citations

Insulinlike effects of sodium selenate in streptozocin-induced diabetic rats

1991 • 113 citations

Evidence for Electron Transfer Reactions Involved in the Cu2+-dependent Thiol Activation of Fat Cell Glucose Utilization

1974 • 103 citations

Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols

2003 • 101 citations

Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling

2003 • 100 citations

Tyrosine Phosphatases as Targets in Metal-Induced Signaling in Human Airway Epithelial Cells

1999 • 98 citations

Catalytic selenols couple the redox cycles of metallothionein and glutathione

2001 • 95 citations

Chromium and insulin resistance

2003 • 92 citations

The CLK Family Kinases, CLK1 and CLK2, Phosphorylate and Activate the Tyrosine Phosphatase, PTP-1B

1999 • 79 citations

Cell signaling by protein tyrosine phosphorylation

1999 • 73 citations

Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.

2001 • 73 citations

Absence of a reductase, NCB5OR, causes insulin-deficient diabetes

2004 • 62 citations

A differential assay for the reduced and oxidized states of metallothionein and thionein

2004 • 51 citations

Regulation of tyrosine phosphorylation cascades by phosphatases: What the actions of vanadium teach us

2003 • 20 citations