Signaling events for metallothionein induction

Oxidative mechanisms in the toxicity of metal ions

1995 • 4,127 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

2003 • 1,204 citations

Regulation of metallothionein gene expression by oxidative stress and metal ions

2000 • 810 citations

[69] Overview of metallothionein

1991 • 793 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

The elusive function of metallothioneins

1998 • 676 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1999 • 607 citations

MT-III, a brain-specific member of the metallothionein gene family.

1992 • 558 citations

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

1994 • 556 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Roles of the NFI/CTF gene family in transcription and development

2000 • 538 citations

How does DNA methylation repress transcription?

1997 • 532 citations

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.

1994 • 489 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

Control of zinc transfer between thionein, metallothionein, and zinc proteins

1998 • 463 citations

Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins

2000 • 427 citations

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

1993 • 382 citations

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

1993 • 381 citations

Regulation of metallothionein genes by heavy metalsappears to be mediated by a zinc-sensitive inhibitor that interacts with aconstitutively active transcription factor, MTF-1.

1994 • 351 citations

Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

1999 • 318 citations

Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures.

1990 • 299 citations

A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.

1988 • 297 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

The Systemic Reaction During Inflammation: The Acute-Phase Proteins

2002 • 276 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

Reactivating the expression of methylation silenced genes in human cancer

2002 • 265 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Zinc metallothionein imported into liver mitochondria modulates respiration

2001 • 250 citations

Antioxidant response element

1994 • 245 citations

Endotoxin induction of murine metallothionein gene expression.

1990 • 239 citations

Human hepatic metallothioneins

1974 • 238 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Increase in metallothionein produced by chemicals that induce oxidative stress

1991 • 232 citations

Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice.

1996 • 219 citations

Zinc and Cadmium Can Promote Rapid Nuclear Translocation of Metal Response Element-binding Transcription Factor-1

2000 • 218 citations

Mechanisms of Multidrug Resistance in Cancer Treatment

1992 • 208 citations

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

1994 • 197 citations

Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response

1980 • 186 citations

Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development

1983 • 183 citations

Regulation of metallothionein gene expression.

1990 • 177 citations

Expression and regulation of brain metallothionein

1995 • 162 citations

Nuclear localization of metallothionein during cell proliferation and differentiation.

2000 • 162 citations

Regulation of Metallothionein Transcription by the Metal-responsive Transcription Factor MTF-1

2002 • 161 citations

Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation

1983 • 159 citations

Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

2002 • 157 citations

Cell cycle regulation of metallothionein in human colonic cancer cells.

1995 • 151 citations

Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development

1987 • 148 citations

Differential metal response and regulation of human heavy metal-inducible genes

1999 • 140 citations

Molecular Analyses of Metallothionein Gene Regulation

1997 • 137 citations

Regulation of metallothionein gene expression

2000 • 134 citations

Metallothionein Is Part of a Zinc-scavenging Mechanism for Cell Survival under Conditions of Extreme Zinc Deprivation

1999 • 133 citations

Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats

1999 • 129 citations

The ontogeny of expression of murine metallothionein: Comparison with the α-fetoprotein gene

1984 • 127 citations

Phosphorylation Is Involved in the Activation of Metal-regulatory Transcription Factor 1 in Response to Metal Ions

2001 • 121 citations

Functions for DNA Methylation in Vertebrates

1993 • 120 citations

A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes

1997 • 116 citations

Histone Acetylation Is Required to Maintain the Unfolded Nucleosome Structure Associated with Transcribing DNA

1998 • 110 citations

The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells.

1994 • 107 citations

Constitutive Expression of Metallothionein-III (MT-III), but Not MT-I, Inhibits Growth When Cells Become Zinc Deficient

1995 • 103 citations

The cellular transcription factor USF cooperates with varicella-zoster virus immediate-early protein 62 to symmetrically activate a bidirectional viral promoter.

1994 • 101 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development

2001 • 99 citations

Suppression of Metallothionein Gene Expression in a Rat Hepatoma Because of Promoter-specific DNA Methylation

2000 • 90 citations

Folding pathway of apo-metallothionein induced by Zn2+, Cd2+ and Co2+

2002 • 84 citations

Basal metallothionein in tumors: Widespread presence of apoprotein

1994 • 82 citations

A Novel Testis-Specific Metallothionein-like Protein,Tesmin,Is an Early Marker of Male Germ Cell Differentiation

1999 • 80 citations

Specific induction of metallothionein synthesis by mitochondrial oxidative stress

2001 • 79 citations

Metallothionein Induction in Response to Restraint Stress

1998 • 79 citations

Metallothionein gene expression and metal regulation during preimplantation mouse embryo development (MT mRNA during early development)

1991 • 78 citations

Heme-hemopexin-mediated induction of metallothionein gene expression.

1992 • 78 citations

High Levels of Metallothionein Messenger RNAs in Male Germ Cells of the Adult Mouse

1991 • 78 citations

Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro

1982 • 76 citations

The Mystique of Epigenetics

1998 • 74 citations

Induction of hepatic metallothionein by nonmetallic compounds associated with acute-phase response in inflammation

1991 • 74 citations

Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells

1989 • 71 citations

JAK/STAT signaling pathways and cancer. Janus kinases/signal transducers and activators of transcription.

2002 • 71 citations

Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression.

1985 • 71 citations

Steroid and nuclear receptors Villefranche-sur-Mer, France, May 25–27, 1999

1999 • 70 citations

Activation of Human Monocytes with Lipopolysaccharide Induces Metallothionein Expression and Is Diminished by Zinc

1994 • 70 citations

Metal- and Tissue-Dependent Relationship between Metallothionein mRNA and Protein

2002 • 62 citations

Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene

1998 • 60 citations

Regulation of the rat metallothionein-I gene by sodium butyrate

1986 • 58 citations

METALLOTHIONEIN INDUCTION BY RESTRAINT STRESS: ROLE OF GLUCOCORTICOIDS AND IL-6

2000 • 57 citations

Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms

1996 • 56 citations

Induction of hepatic metallothionein by paraquat

1992 • 55 citations

Effect of non‐toxic mercury, zinc or cadmium pretreatment on the capacity of human monocytes to undergo lipopolysaccharide‐induced activation

1997 • 55 citations

Antisense down-regulation of metallothionein in a human monocytic cell line alters adherence, invasion, and the respiratory burst.

1994 • 54 citations

Sensitivity to Cadmium-Induced Genotoxicity in Rat Testicular Cells Is Associated with Minimal Expression of the Metallothionein Gene

1995 • 53 citations

Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate

1992 • 53 citations

Temporal changes in metallothionein gene transcription in rat kidney and liver: relationship to content of mercury and metallothionein protein.

2000 • 51 citations

Induction of metallothionein synthesis by zinc in cadmium pretreated rats

1990 • 51 citations

Metal-Specific Posttranscriptional Control of Human Metallothionein Genes

1989 • 45 citations

Induction of metallothionein by diethyl maleate

1992 • 41 citations

Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium

1996 • 39 citations

Requirement for Cooperative Interaction of Interleukin-6 Responsive Element Type 2 and Glucocorticoid Responsive Element in the Synergistic Activation of Mouse Metallothionein-I Gene by Interleukin-6 and Glucocorticoid

1998 • 34 citations

Differential Sensitivity of Zinc Finger Transcription Factors MTF-1, Sp1 and Krox-20 to CpG Methylation of Their Binding Sites

1996 • 34 citations

Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes

2002 • 34 citations

Increased Metallothionein in Mouse Liver, Kidneys, and Duodenum during Lactation

2001 • 33 citations

Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry.

1993 • 33 citations

Effects of Metals on Gene Expression

1995 • 30 citations

Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line.

1995 • 30 citations

Regulation of metallothionein gene expression by TNF-α and IFN-β in human fibroblasts

1995 • 29 citations

Abundance of hepatic metallothionein mRNA is increased by protein-synthesis inhibitors. Evidence for transcriptional activation and post-transcriptional regulation

1991 • 29 citations

Blocking effect of anti-mouse interleukin-6 monoclonal antibody and glucocorticoid receptor antagonist, RU38486, on metallothionein-inducing activity of serum from lipopolysaccharide-treated mice

1996 • 27 citations

trans Repression of the Human Metallothionein IIA Gene Promoter by PZ120, a Novel 120-Kilodalton Zinc Finger Protein

1999 • 24 citations

Zinc-Metallothionein Levels Are Correlated with Enhanced Glucocorticoid Responsiveness in Mouse Cells Exposed to ZnCl2, HgCl2, and Heat Shock

2001 • 23 citations

Enhanced transcription of metallothionein genes in rat kidney: effect of uninephrectomy and compensatory renal growth

1995 • 21 citations

Acute treatment of mice with cadmium salts results in amplification of the metallothlonein-1 gene in liver

1985 • 20 citations

Nuclease sensitivity of α-fetoprotein, metallothionein-1, and immunoglobulin gene sequences in mouse during development

1987 • 20 citations

Examination of potential mechanism(s) of metallothionein induction by diethyl maleate

1992 • 19 citations

Activation of the Metallothionein-I Gene Promoter in Response to Cadmium and USFin Vitro

1997 • 19 citations

The metallothionein structural motif in gene expression.

1994 • 14 citations

Role of IL-6 in the induction of hepatic metallothionein in mice after partial hepatectomy

2000 • 14 citations

Effect of 5-azacytidine on metallothionein inducibility and sensitivity to lethality of cadmium in rat osteosarcoma (ROS 172.8) cells

1990 • 12 citations

Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter

1998 • 11 citations

Sequence homology of Chinese hamster metallothionein genes I and II to those of the mouse and rat, and their amplification in Cd-resistant cells

1994 • 8 citations

Identification of a sequence within the mouse metallothionein-I gene promoter mediating its basal transcription and of a protein interacting with this element.

1993 • 7 citations

S-phase-dependent action of cycloheximide in relieving chromatin-mediated general transcriptional repression

1998 • 6 citations

Synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid

1999 • 5 citations

Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1

1999 • 3 citations

Transcription factors involved in heavy metal regulation of the human metallothionein-IIA gene

1999 • 2 citations