Alcohol-Induced Myocardial Fibrosis in Metallothionein-Null Mice

[69] Overview of metallothionein

1991 • 793 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

The Function of Zinc Metallothionein: A Link between Cellular Zinc and Redox State

2000 • 411 citations

Structure of the metal clusters in rabbit liver metallothionein

1980 • 367 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

The function of metallothionein

1995 • 299 citations

Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

1997 • 249 citations

Alcohol and the Cardiovascular System

2005 • 236 citations

Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein

2002 • 214 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

The Antioxidant Function of Metallothionein in the Heart

1999 • 184 citations

Alcohol and the Cardiovascular System

1990 • 170 citations

Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes.

2001 • 167 citations

Early changes in left ventricular function in chronic asymptomatic alcoholics: relation to the duration of heavy drinking

2000 • 166 citations

Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy

2000 • 153 citations

Alcohol Intoxication, Injuries, and Dangerous Behaviors–And the Revolving Emergency Department Door

1990 • 135 citations

Echocardiographic abnormalities in chronic alcoholics with and without overt congestive heart failure

1981 • 132 citations

Alcohol abuse and dilated cardiomyopathy in men

2000 • 128 citations

Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart.

2001 • 128 citations

Metallothionein (MT)-Null Mice Are Sensitive to Cisplatin-Induced Hepatotoxicity

1998 • 119 citations

Zinc Deficiency in the Alcoholic: A Review

1983 • 115 citations

Degrees of alcohol intoxication in 117 hospitalized cases.

1991 • 114 citations

Effects of Ethanol on the Contractile Function of the Heart: A Review

1994 • 110 citations

Alcohol consumption and idiopathic dilated cardiomyopathy: A case control study

1998 • 106 citations

Metallothionein-Null Mice Are More Sensitive than Wild-Type Mice to Liver Injury Induced by Repeated Exposure to Cadmium

2000 • 102 citations

The heart in chronic alcoholism: a noninvasive study

1980 • 101 citations

Zinc Metabolism in Alcoholic Liver Disease

1986 • 99 citations

Left ventricular filling impairment in asymptomatic chronic alcoholics

1990 • 92 citations

Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats.

1992 • 82 citations

Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration

1992 • 76 citations

Trace Elements and Chronic Liver Diseases

1997 • 73 citations

Interactions among nickel, copper, and iron in rats

1982 • 68 citations

The effects of chronic ethanol consumption on cardiac function in rats

1982 • 64 citations

Antiapoptotic Effect and Inhibition of Ischemia/Reperfusion-Induced Myocardial Injury in Metallothionein-Overexpressing Transgenic Mice

2003 • 62 citations

Decrease in Liver Collagen Accumulation in Carbon Tetrachloride-Injured and Normal Growing Rats Upon Administration of Zinc

1984 • 60 citations

Concentations of Copper, Zinc, and Magnesium in Sera from Patients with Idiopathic Dilated Cardiomyopathy

2003 • 58 citations

Interactions among nickel, copper, and iron in rats

1981 • 55 citations

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

2001 • 54 citations

Hepatic collagen proline hydroxylase activity in alcoholic liver disease

1976 • 54 citations

Hepatic prolyl hydroxylase and collagen synthesis in patients with alcoholic liver disease

1979 • 54 citations

Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease

1997 • 52 citations

Trace element concentrations (Cu, Zn, Fe) in sera from patients with dilated cardiomyopathy

1993 • 46 citations

Metallothionein Gene Therapy for Chemical-Induced Liver Fibrosis in Mice

2004 • 40 citations

Fibrogenic and collagenolytic activity in carbon-tetrachloride-injured rats: beneficial effects of zinc administration

1994 • 38 citations

Noninvasive Assessment of Left Ventricular Diastolic Function by Pulsed Doppler Echocardiography in Young Alcoholics

1988 • 32 citations

Ethanol elimination rates in an ED population

1995 • 31 citations

Alcohol and Cardiovascular Diseases: A Historical Overview

2007 • 30 citations

Cardiac structure and function after short-term ethanol consumption in rats

2003 • 29 citations

TRACE ELEMENT AND VITAMIN DEFICIENCY IN ALCOHOLIC AND CONTROL SUBJECTS

1991 • 25 citations

Experimental models for studying the effects of ethanol on the myocardium

1987 • 18 citations

Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy

1984 • 15 citations

The Antioxidant and Hepato-Protective Effects of Zinc are Related to Hepatic Cytochrome P450 Depression and Metallothionein Induction in Rats with Experimental Cirrhosis

2001 • 15 citations

Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats.

1992 • 14 citations

Alcohol and Cardiovascular Diseases: An Historical Overview

2000 • 8 citations