Zinc coordination, function, and structure of zinc enzymes and other proteins

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Biochemistry of metallothionein

1988 • 1,222 citations

Potential Metal-Binding Domains in Nucleic Acid Binding Proteins

1986 • 1,096 citations

3 Alcohol Dehydrogenases

1975 • 706 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Metallothionein: a Cadmium and Zinc-containing Protein from Equine Renal Cortex

1961 • 685 citations

‘Zinc fingers’: a novel protein motif for nucleic acid recognition

1987 • 676 citations

Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain

1989 • 630 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus

1989 • 451 citations

Crystal Structure of Human Carbonic Anhydrase C

1972 • 446 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Active-site zinc ligands and activated H2O of zinc enzymes.

1990 • 432 citations

The primary structure of transcription factor TFIIIA has 12 consecutive repeats

1985 • 413 citations

Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.

1988 • 411 citations

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

1986 • 409 citations

Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA

1986 • 406 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Structure of the metal clusters in rabbit liver metallothionein

1980 • 367 citations

Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene.

1983 • 356 citations

The Conformation of Thermolysin

1974 • 332 citations

Xenopus 5S gene transcription factor, TFIIIA: Characterization of a cDNA clone and measurement of RNA levels throughout development

1984 • 319 citations

Metal-dependent folding of a single zinc finger from transcription factor IIIA.

1987 • 301 citations

Three-dimensional Structure of Thermolysin

1972 • 292 citations

Crystal Structure of Cd,Zn Metallothionein

1986 • 270 citations

Crystal structure of human erythrocyte carbonic anhydrase B. Three-dimensional structure at a nominal 2.2-A resolution.

1975 • 245 citations

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA

1988 • 241 citations

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

1987 • 238 citations

The release of collagenase as an inactive proenzyme by bone explants in culture

1972 • 236 citations

Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene

1988 • 232 citations

Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli

1982 • 227 citations

Evidence that latent collagenases are enzyme-inhibitor complexes

1977 • 223 citations

Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA

1986 • 217 citations

Characterization of the individual collagenases from Clostridium histolyticum

1984 • 215 citations

GAL4 transcription factor is not a "zinc finger" but forms a Zn(II)2Cys6 binuclear cluster.

1990 • 211 citations

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin

1983 • 208 citations

Detergent-activation of latent collagenase and resolution of its component molecules

1982 • 202 citations

A multigene family encoding several “finger” structures is present and differentially active in mammalian genomes

1987 • 197 citations

Cloning and sequence analysis of cDNA for bovine carboxypeptidase E

1986 • 196 citations

Proteolytic processing and physiological regulation

1989 • 195 citations

The molecular weight and properties of a neutral metallo-endopeptidase from rabbit kidney brush border

1974 • 185 citations

Metal Substitutions and Inhibition of Thermolysin: Spectra of the Cobalt Enzyme

1974 • 184 citations

Membrane bound pituitary metalloendopeptidase: Apparent identity to enkephalinase

1981 • 175 citations

Structure of alkaline phosphatases

1990 • 174 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

A specific collagenase from rabbit fibroblasts in monolayer culture

1974 • 168 citations

Purification and separation of individual collagenases of Clostridium histolyticum using red dye ligand chromatography

1984 • 157 citations

A retroviral Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure.

1989 • 153 citations

Polypeptide fold in the two metal clusters of metallothionein-2 by nuclear magnetic resonance in solution

1986 • 142 citations

Sequence and structure of the Serendipity locus of Drosophila melanogaster

1985 • 138 citations

Gene 32 protein, the single-stranded DNA binding protein from bacteriophage T4, is a zinc metalloprotein.

1986 • 137 citations

The structure of carboxypeptidase A. VIII. Atomic interpretation at 0.2 nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions

1970 • 134 citations

Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases

1989 • 134 citations

Zinc and gene expression

1981 • 133 citations

Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 Å resolution

1982 • 123 citations

Structure of carboxypeptidase B at 2.8 Å resolution

1976 • 121 citations

Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site.

1988 • 119 citations

Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin

1988 • 117 citations

Amino Acid Sequence Deduced from a Rat Kidney cDNA Suggests It Encodes the Zn-Peptidase Aminopeptidase N

1989 • 116 citations

Molecular Cloning and Sequencing of the cDNA for Human Membrane-bound Carboxypeptidase M

1989 • 113 citations

An X-ray-crystallographic study of β-lactamase II from Bacillus cereus at 0.35 nm resolution

1987 • 102 citations

Metal ion exchange reactions in cage molecules: the systems [M4-nM'n(SC6H5)10]2- (M, M' = Fe(II), Co(II), Zn(II), Cd(II)) with adamantane-like stereochemistry and the structure of [Fe4(SC6H5)10]2-

1982 • 100 citations

Synthesis and release of procollagenase by cultured fibroblasts.

1976 • 99 citations

Astacus protease, a zinc metalloenzyme

1988 • 93 citations

Structure and function of the Zn(II) binding site within the DNA-binding domain of the GAL4 transcription factor.

1989 • 89 citations

Metal binding stoichiometry and mechanism of metal ion modulation of the activity of porcine kidney leucine aminopeptidase

1981 • 89 citations

Latent and Active Human Polymorphonuclear Leukocyte Collagenases

1983 • 87 citations

Finger-loops, oncogenes, and metals. Claude Passmore Brown memorial lecture.

1988 • 83 citations

Zinc: biochemistry, physiology, toxicology and clinical pathology.

1988 • 82 citations

Short and long spacer sequences and other structural features of zinc binding sites in zinc enzymes

1989 • 78 citations

Spectral and kinetic studies of metal-substituted Aeromonas aminopeptidase: nonidentical, interacting metal-binding sites

1985 • 75 citations

cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)

1989 • 71 citations

Primary structure homologies between two zinc metallopeptidases, the neutral endopeptidase 24.11 ("enkephalinase") and thermolysin, through clustering analysis

1988 • 66 citations

Human liver aminopeptidase. Role of metal ions in mechanism of action

1974 • 63 citations

The guanine‐nucleotide binding proteins EMBO‐NATO‐CEC advanced research workshop organized by L. Bosch, B. Kraal and A. Parmeggiani in Renesse, The Netherlands, August 6–11, 1988

1988 • 56 citations

Nucleotide sequence of the pepN gene encoding aminopeptidase N of Escherichia coli

1986 • 55 citations

Zinc release from Xenopus transcription factor IIIA induced by chemical modifications

1989 • 46 citations

Zinc biochemistry in normal and neoplastic growth processes

1977 • 45 citations

Leucine aminopeptidase (bovine lens). Effect of pH on the relative binding of Zn2+ and Mg2+ to and on activation of the enzyme.

1976 • 43 citations

Physical and Chemical Characterization of Pig Kidney Particulate Aminopeptidase

1971 • 43 citations

Electrochemical preparation and structure of an unusual zinc(II) thiolato anionic cluster

1981 • 36 citations

Chemical approaches to the mode of action of carboxypeptidase A

1970 • 34 citations

Thermal denaturation of T4 gene 32 protein: effects of zinc removal and substitution

1988 • 30 citations

The zinc-benzenethiolate-halide system. Synthesis and structure of the hexakis(.mu.-(benzenethiolato))-bis(benzenethiolato)dichlorotetrazincate(II) dianion

1981 • 28 citations

Bacillus subtilis aminopeptidase: Purification, characterization and some enzymatic properties

1979 • 27 citations

The nucleotide sequence of the pepN gene and its over-expression in Escherichia coli

1986 • 27 citations

Isolation and properties of an aminopeptidase from Bacillus licheniformis

1978 • 26 citations

[1] Preparation of metal-free water

1988 • 15 citations

The Role of Zinc in Biochemical Processes

1979 • 15 citations

Kinetics and mechanism of Ru(III) catalyzed oxidation of Se(IV) by Ce(IV)

1981 • 6 citations