Raf: A Strategic Target for Therapeutic Development Against Cancer

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

2004 • 3,873 citations

ras GENES

1987 • 3,818 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

High frequency of BRAF mutations in nevi

2002 • 1,701 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

The EGFR family and its ligands in human cancer

2001 • 1,554 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

2003 • 1,490 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas

2003 • 1,042 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

BRAF and RAS mutations in human lung cancer and melanoma.

2002 • 979 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

BRAF Mutation in Papillary Thyroid Carcinoma

2003 • 915 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Tumor Regression by Targeted Gene Delivery to the Neovasculature

2002 • 848 citations

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

1997 • 848 citations

Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

2003 • 829 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

2002 • 526 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

1999 • 499 citations

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

1983 • 485 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Raf proteins and cancer: B-Raf is identified as a mutational target

2003 • 454 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Ras effectors

1996 • 445 citations

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1996 • 444 citations

Cdc25A is a novel phosphatase functioning early in the cell cycle.

1994 • 442 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Pharmacological inhibitors of MAPK pathways

2002 • 437 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

Cell cycle regulation by the Cdc25 phosphatase family

2000 • 433 citations

Discovery of a novel Raf kinase inhibitor.

2001 • 417 citations

Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

2002 • 408 citations

Mechanisms of regulating the Raf kinase family

2003 • 397 citations

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

2003 • 390 citations

Ras Activation of the Raf Kinase: Tyrosine Kinase Recruitment of the MAP Kinase Cascade

2001 • 384 citations

Modulation of p53, ErbB1, ErbB2, and Raf-1 Expression in Lung Cancer Cells by Depsipeptide FR901228

2002 • 367 citations

Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

1997 • 361 citations

Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43–9006) in patients with advanced renal cell carcinoma (RCC)

2005 • 358 citations

The Ras signal transduction pathway

1994 • 345 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

2003 • 334 citations

Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma

2003 • 333 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS

1997 • 329 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

2001 • 311 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Active Ras induces heterodimerization of cRaf and BRaf.

2001 • 308 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

1995 • 304 citations

Signaling by dual specificity kinases

1998 • 291 citations

BAY 43-9006: Preclinical Data

2002 • 289 citations

Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility

1999 • 285 citations

Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity

2001 • 280 citations

Regulation of Raf-1 activation and signalling by dephosphorylation

2002 • 277 citations

Isotype-Specific Functions of Raf Kinases

1999 • 259 citations

Positive and negative regulation of Raf kinase activity and function by phosphorylation

2001 • 257 citations

Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis

2001 • 257 citations

Cell cycle targets of Ras/Raf signalling

1998 • 257 citations

Negative regulation of the serine/threonine kinase B-Raf by Akt

2000 • 249 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601

2000 • 239 citations

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1996 • 234 citations

KSR: a MAPK scaffold of the Ras pathway?

2001 • 234 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

2003 • 226 citations

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

2000 • 225 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma

2003 • 215 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt

2000 • 209 citations

Structure and biological activity of human homologs of the raf/mil oncogene.

1985 • 203 citations

The discovery of potent cRaf1 kinase inhibitors

2000 • 202 citations

[40] Biological assays for Ras transformation

1995 • 199 citations

Cell-Type Specific Integration of Cross-Talk between Extracellular Signal-Regulated Kinase and cAMP Signaling

2000 • 198 citations

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1997 • 196 citations

A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function

1995 • 196 citations

Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins

1997 • 185 citations

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

1994 • 175 citations

Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

2000 • 174 citations

Ras effectors and their role in mitogenesis and oncogenesis

1997 • 167 citations

KSR stimulates Raf-1 activity in a kinase-independent manner

1997 • 166 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

1995 • 161 citations

Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age

2003 • 161 citations

Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells

2001 • 158 citations

Activation of Raf by ionizing radiation

1996 • 158 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.

1994 • 154 citations

A genome-based strategy uncovers frequent BRAF mutations in melanoma

2002 • 152 citations

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

1999 • 150 citations

The raf Oncogene Is Associated with a Radiation-Resistant Human Laryngeal Cancer

1987 • 150 citations

Mutational activation of c-raf-1 and definition of the minimal transforming sequence.

1990 • 146 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

BRAF and KRAS mutations in stomach cancer

2003 • 139 citations

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

2000 • 138 citations

Lack of BRAF Mutation in Primary Uveal Melanoma

2003 • 137 citations

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C- raf kinase supports an antisense mechanism of action in vivo

1996 • 136 citations

Phase I Clinical/Pharmacokinetic and Pharmacodynamic Trial of the c-raf-1 Antisense Oligonucleotide ISIS 5132 (CGP 69846A)

1999 • 131 citations

Randomized discontinuation trials: Utility and efficiency

1993 • 131 citations

Mutations of the BRAF gene in squamous cell carcinoma of the head and neck

2003 • 129 citations

A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer.

2000 • 128 citations

Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt.

1999 • 127 citations

Dephosphorylation of Ser-259 Regulates Raf-1 Membrane Association

2002 • 121 citations

Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611

1984 • 121 citations

Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (cgp 69846a) after intravenous and subcutaneous administration

1997 • 121 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

1998 • 119 citations

A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.

2002 • 118 citations

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

2000 • 116 citations

Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs.

2003 • 115 citations

Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors

2002 • 114 citations

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

2001 • 114 citations

Preliminary antitumor activity of BAY 43–9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT)

2004 • 111 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf

1984 • 110 citations

Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway

1997 • 109 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma

2004 • 107 citations

Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors

2002 • 106 citations

Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.

2000 • 106 citations

Associations of B- and C-Raf with Cholesterol, Phosphatidylserine, and Lipid Second Messengers

2002 • 104 citations

Serum- and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf

2001 • 102 citations

Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins

1995 • 100 citations

Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43–9006) in patients with advanced renal cell carcinoma (RCC)

2005 • 100 citations

Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression.

1997 • 98 citations

Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study.

2002 • 96 citations

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences.

1987 • 95 citations

Thyrotropin Activates Mitogen-Activated Protein Kinase Pathway in FRTL-5 by a cAMP-Dependent Protein Kinase A-Independent Mechanism

2001 • 93 citations

Expression of the c-raf Protooncogene, γ-Glutamyltranspeptidase, and Gap Junction Protein in Rat Liver Neoplasms

1988 • 92 citations

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

1996 • 88 citations

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

1999 • 84 citations

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

2000 • 84 citations

Localization of Endogenous Grb10 to the Mitochondria and Its Interaction with the Mitochondrial-associated Raf-1 Pool

1999 • 82 citations

Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

2001 • 82 citations

Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.

1996 • 77 citations

differential c-myc, c-jun, c-raf and p53 expression in squamous cell carcinoma of the head and neck: Implication in drug and radioresistance

1995 • 73 citations

Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: an NCIC clinical trials group study (NCIC IND.116)☆

2003 • 71 citations

Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma

2004 • 70 citations

A Common onc Gene Sequence Transduced by Avian Carcinoma Virus MH2 and by Murine Sarcoma Virus 3611

1984 • 70 citations

BRAF mutations in non-Hodgkin's lymphoma

2003 • 69 citations

Antisense technology for cancer therapy: does it make sense?

1993 • 68 citations

Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

1994 • 66 citations

The Raf‐1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments

2000 • 64 citations

Differential Expression and Mutation of therasFamily Genes in Human Breast Cancer

1998 • 64 citations

Isoform-Specific Localization of A-RAF in Mitochondria

2000 • 63 citations

Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?

1995 • 62 citations

Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo.

1995 • 58 citations

Activation of c-Raf Kinase by Ultraviolet Light

2002 • 55 citations

Raf‐1 and B‐Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

1999 • 55 citations

Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

1993 • 55 citations

A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation

2003 • 52 citations

Antisense raf Oligodeoxyribonucleotide Is a Radiosensitizer In Vivo

1999 • 51 citations

Toxicological and pharmacokinetic properties of chemically modified antisense oligonucleotide inhibitors of PKC-alpha and C-raf kinase.

1997 • 49 citations

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

2003 • 49 citations

BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience

2004 • 48 citations

Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation.

1995 • 48 citations

Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma

1989 • 48 citations

Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol

2003 • 46 citations

Patterns of proto‐oncogene expression in human glioma cell lines

1989 • 39 citations

ras Proto-Oncogene Activation in Human Malignancy

1995 • 38 citations

Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.

1992 • 37 citations

Involvement of the RAFI locus, at band 3p25, in the 3p deletion of small‐cell lung cancer

1991 • 37 citations

Connection between Integrins and Cell Activation in Rat Adrenal Glomerulosa Cells: A Role for Arg-Gly-Asp Peptide in the Activation of the p42/p44^mapkPathway and Intracellular Calcium

2003 • 33 citations

Antitumor effect and potentiation or reduction in cytotoxic drug activity in human colon carcinoma cells by the Raf kinase inhibitor (RKI) BAY 43-9006

2003 • 31 citations

Molecular cloning and characterization of an activated human c-raf-1 gene.

1987 • 30 citations

Antisense oligonucleotide therapy in cancer.

2003 • 28 citations

A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors

2003 • 28 citations

Frequent loss of heterozygosity on chromosome 6p in uveal melanoma

1999 • 26 citations

Interactions between p21ras proteins and their GTPase activating proteins.

1992 • 26 citations

Erythropoietin-Stimulated Raf-1 Tyrosine Phosphorylation Is Associated with the Tyrosine Kinase Lyn in J2E Erythroleukemic Cells

2001 • 26 citations

Raf-1 protein expression in human breast cancer cells

1995 • 25 citations

Mapping by chromosome sorting of several gene probes, including C‐myc, to the derivative chromosomes of a 3;8 translocation associated with familial renal cancer

1986 • 24 citations

Drug-drug interaction pharmacokinetic study with the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with irinotecan (CPT-11) in patients with solid tumors

2003 • 23 citations

Activation of Raf-1 in Human Pancreatic Adenocarcinoma

1997 • 22 citations

Specific abnormalities of chromosome 14 in patients with acute type of adult T‐cell leukemia/lymphoma

1987 • 20 citations

Results of a phase I trial of BAY 43–9006 in combination with doxorubicin in patients with refractory solid tumors

2004 • 19 citations

A phase I/II trial of BAY 43–9006 and gemcitabine in advanced solid tumors and in advanced pancreatic cancer

2004 • 19 citations

A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity.

2001 • 17 citations

Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

1997 • 16 citations

A mechanism of c-raf-1 activation: fusion of the lipocortin II amino-terminal sequence with the c-raf-1 kinase domain.

1989 • 16 citations

Genomic Organization and Nucleotide Sequence of the Coding Region of the Chicken c-Rmil(B-raf-1) Proto-oncogene

1993 • 15 citations

Tpl‐2 induces apoptosis by promoting the assembly of protein complexes that contain caspase‐9, the adapter protein Tvl‐1, and procaspase‐3

2001 • 15 citations

Activity of the Raf Kinase Inhibitor BAY 43-9006 in Patients with Advanced Solid Tumors

2003 • 12 citations

Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane

2003 • 12 citations

C-raf expression in early rat liver tumorigenesis after promotion with polychlorinated biphenyls or phenobarbital

1994 • 12 citations

Correlation of constitutive activation of raf-1 with morphological transformation and abrogation of tyrosine phosphorylation of distinct sets of proteins in human squamous carcinoma cells

1997 • 8 citations

Results of a phase I trial of BAY 43–9006 in combination with oxaliplatin in patients with refractory solid tumors

2004 • 6 citations

[B-raf gene encodes for multiple isoforms with Mek-1 kinase activity].

1995 • 4 citations

Expression of oncogenes in human hepatoma cell lines.

1988 • 3 citations

Integration of intra-operative electron irradiation (IOERT) in breast conserving treatment for T1/T2N0 breast cancer: Early results of a phase II tria

2004 • 2 citations

A Small Peptide Derived from the Aminoterminus of c-Raf-1 Inhibits c-Raf-1/Ras Binding

1995 • 2 citations

Activation of rat and human c-raf(-1) by rearrangement.

1986 • 2 citations

Inhibition of ERK phosphorylation in patients treated with the Raf kinase inhibitor BAY 43-9006

2002 • 1 citations