Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Protein modules and signalling networks

1995 • 2,447 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Signal transduction via platelet-derived growth factor receptors

1998 • 735 citations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

1992 • 681 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

1998 • 480 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

1994 • 414 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

2000 • 268 citations

Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

1997 • 261 citations

Negative regulation of the serine/threonine kinase B-Raf by Akt

2000 • 249 citations

Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury.

1993 • 243 citations

Mechanical Strain Increases Smooth Muscle and Decreases Nonmuscle Myosin Expression in Rat Vascular Smooth Muscle Cells

1996 • 228 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt

2000 • 209 citations

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt

2000 • 195 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

1998 • 191 citations

Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells

1999 • 189 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase

1998 • 181 citations

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1

1999 • 146 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.

1991 • 113 citations

Preparation of functional smooth muscle cells from the rabbit aorta.

1978 • 108 citations

Expression of the Smooth Muscle Myosin Heavy Chain Gene Is Regulated by a Negative-acting GC-rich Element Located between Two Positive-acting Serum Response Factor-binding Elements

1997 • 105 citations

Effects of Stimulation of AMP-activated Protein Kinase on Insulin-like Growth Factor 1- and Epidermal Growth Factor-dependent Extracellular Signal-regulated Kinase Pathway

2001 • 86 citations

Purification and Characterization of Gβγ-responsive Phosphoinositide 3-Kinases from Pig Platelet Cytosol

1997 • 84 citations

Aberrant Ras Regulation and Reduced p190 Tyrosine Phosphorylation in Cells Lacking p120-Gap

1997 • 80 citations

The insulin-like growth factor system in vascular smooth muscle: Interaction with insulin and growth factors

1995 • 69 citations

Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells

2001 • 61 citations

Regulator of G-protein Signaling 3 (RGS3) Inhibits Gβ1γ2-induced Inositol Phosphate Production, Mitogen-activated Protein Kinase Activation, and Akt Activation

2001 • 61 citations

The GTPase-Activating Protein of Ras Suppresses Platelet-Derived Growth Factor β Receptor Signaling by Silencing Phospholipase C-γ1

1995 • 52 citations

Phosphorylation of c-Raf-1 by Protein Kinase A Interferes with Activation

1994 • 52 citations

Farnesylation of Ras is important for the interaction with phosphoinositide 3‐kinase γ

1999 • 50 citations

Gβγ Mediate Differentiation of Vascular Smooth Muscle Cells

2001 • 29 citations

Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src

1999 • 21 citations

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF

2001 • 17 citations