Raf-1 protein expression in human breast cancer cells

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

1983 • 485 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

1984 • 201 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.

1990 • 179 citations

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.

1991 • 165 citations

Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide

1987 • 161 citations

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.

1990 • 148 citations

MAP kinase and the activation of quiescent cells

1993 • 140 citations

The human c-Kirstenrasgene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231

1987 • 130 citations

raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction

1988 • 124 citations

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

1991 • 115 citations

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer.

1985 • 113 citations

Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor.

1992 • 110 citations

Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features.

1992 • 103 citations

Insulin activates the Raf-1 protein kinase.

1990 • 99 citations

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences.

1987 • 95 citations

Epidermal growth factor receptor in human breast cancer: Correlation with steroid hormone receptors and axillary lymph node involvement

1988 • 93 citations

Detection of the myristylated gag-raf transforming protein with raf-specific antipeptide sera

1985 • 87 citations

Complementation of byrl in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase

1993 • 73 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

Immunocytochemical and biochemical analysis of epidermal growth factor receptor expression in human breast cancer tissues: Relationship to estrogen receptor and lymphatic invasion

1989 • 58 citations

Epidermal growth factor receptor in human breast cancers: Correlation with estrogen and progesterone receptors

1988 • 58 citations

The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells.

1991 • 36 citations

Activation of human c-raf-1 by replacing the N-terminal region with different sequences

1987 • 33 citations

Activation of Human raf Transforming Genes by Deletion of Normal Amino-Terminal Coding Sequences

1987 • 29 citations

Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes.

1991 • 24 citations

Altered Transcriptional Activity of c-fos Promoter Plasmids in v-raf-Transformed NIH 3T3 Cells

1990 • 21 citations

Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.

1992 • 8 citations