Activation of Raf-1 in Human Pancreatic Adenocarcinoma

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The pathway to signal achievement

1993 • 563 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1995 • 202 citations

The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

1994 • 187 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

1994 • 162 citations

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.

1993 • 101 citations

Signaling, mitogenesis and the cytoskeleton: Where the action is

1995 • 76 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

The Raf-1 serine/threonine protein kinase.

1994 • 67 citations

Making connections: RNA-dependent amino acid recognition

1995 • 29 citations