Modulation of p53, ErbB1, ErbB2, and Raf-1 Expression in Lung Cancer Cells by Depsipeptide FR901228

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

2001 • 923 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Histone methylation versus histone acetylation: new insights into epigenetic regulation

2001 • 689 citations

Regulation of E2F1 activity by acetylation

2000 • 654 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization

2000 • 595 citations

FR901228, a novel antitumor bicyclic depsipeptide produced by chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.

1994 • 484 citations

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

1998 • 481 citations

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1998 • 474 citations

Regulation of p53 stability

1999 • 413 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

Novobiocin and Related Coumarins and Depletion of Heat Shock Protein 90-Dependent Signaling Proteins

2000 • 392 citations

Histone acetylation and disease

2001 • 331 citations

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

1997 • 329 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 314 citations

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin

2001 • 313 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1996 • 309 citations

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

1999 • 297 citations

Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

2001 • 281 citations

Acetylation control of the retinoblastoma tumour-suppressor protein

2001 • 280 citations

P21-dependent G1arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

2000 • 280 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

2001 • 218 citations

Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation

1995 • 211 citations

Regulation of p53 stability and activity in response to genotoxic stress

2000 • 186 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

Sequential 5-Aza-2’-deoxycytidine-Depsipeptide FR901228 Treatment Induces Apoptosis Preferentially in Cancer Cells and Facilitates Their Recognition by Cytolytic T Lymphocytes Specific for NY-ESO-1

2001 • 164 citations

Role of Histone Acetylation in the Assembly and Modulation of Chromatin Structures

2001 • 150 citations

Histone deacetylase inhibitors as potential anti-skin cancer agents.

1999 • 140 citations

Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines

2000 • 123 citations

Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras

2000 • 120 citations

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

1999 • 114 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Mechanism of Cell Cycle Arrest Caused by Histone Deacetylase Inhibitors in Human Carcinoma Cells.

2000 • 107 citations

Depletion of p185 erbB2 , Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

1997 • 104 citations

Histone acetylation and the cell-cycle in cancer

2001 • 98 citations

Sodium butyrate modulates cell cycle‐related proteins in HT29 human colonic adenocarcinoma cells

2000 • 74 citations

Uncoupling Raf1 from MEK1/2 Impairs Only a Subset of Cellular Responses to Raf Activation

2000 • 72 citations

Histone Hyperacetylation Induced by Histone Deacetylase Inhibitors Is Not Sufficient to Cause Growth Inhibition in Human Dermal Fibroblasts

2001 • 68 citations

Regulation of p53 expression by the RAS-MAP kinase pathway

2001 • 56 citations

Trichostatin A Modulates Expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

2000 • 51 citations

Modulation of cell cycle-related protein expression by sodium butyrate in human non-small cell lung cancer cell lines

2001 • 47 citations

Participation of Histones and Histone-Modifying Enzymes in Cell Functions through Alterations in Chromatin Structure

2001 • 39 citations

Histone acetylation and the cell-cycle in cancer

2001 • 15 citations