Induction and regulation of epithelial–mesenchymal transitions

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Integrin Signaling

1999 • 3,705 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

1996 • 303 citations

Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

1999 • 300 citations

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration

1999 • 276 citations

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

1992 • 271 citations

Phosphorylation of Tyrosine Residues 31 and 118 on Paxillin Regulates Cell Migration through an Association with Crk in Nbt-II Cells

2000 • 268 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Adenovirus Endocytosis via α _v Integrins Requires Phosphoinositide-3-OH Kinase

1998 • 249 citations

Epithelium-Mesenchyme Transition during Neural Crest Development

1995 • 247 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis

1994 • 234 citations

Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells

1985 • 226 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Integrins and GTPases in tumour cell growth, motility and invasion

1998 • 219 citations

Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

1989 • 210 citations

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

1993 • 209 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Epithelial Mesenchymal Transition by c-Fos Estrogen Receptor Activation Involves Nuclear Translocation of β-Catenin and Upregulation of β-Catenin/Lymphoid Enhancer Binding Factor-1 Transcriptional Activity

2000 • 207 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

1994 • 198 citations

Genetics of src: Structure and Functional Organization of a Protein Tyrosine Kinase

1989 • 197 citations

The p21Rac/Cdc42-activated kinases (PAKs)

1998 • 190 citations

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

1995 • 180 citations

Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration

1999 • 171 citations

Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.

1991 • 164 citations

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.

1996 • 162 citations

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

1999 • 159 citations

The Transcription Factor AP-1 Is Required for EGF-induced Activation of Rho-like GTPases, Cytoskeletal Rearrangements, Motility, and In Vitro Invasion of A431 Cells

1998 • 154 citations

Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function

1999 • 150 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression

1996 • 142 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells.

1994 • 135 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Regulation of JNK by Src During Drosophila Development

2000 • 124 citations

Involvement of Phosphatidylinositide 3′-Kinase and Rac in Platelet-Derived Growth Factor-Induced Actin Reorganization and Chemotaxis

1997 • 120 citations

The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development

1999 • 116 citations

p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells

1995 • 112 citations

Nonmitogenic Morphoregulatory Action of pp6O^v-src on Multicellular Epithelial Structures

1987 • 110 citations

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

1995 • 107 citations

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.

1996 • 100 citations

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

1990 • 95 citations

Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering

1998 • 95 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

Epithelio-Mesenchymal Transformation during Formation of the Mesoderm in the Mammalian Embryo

1995 • 91 citations

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

1988 • 87 citations

The Rho GTPases in Macrophage Motility and Chemotaxis

1998 • 85 citations

The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells.

1997 • 82 citations

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.

1995 • 81 citations

Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM in peri-implantation mouse embryos and extraembryonic membranes

1986 • 80 citations

Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures.

1987 • 76 citations

Cytoskeletal targets for oncogenic tyrosine kinases

1991 • 73 citations

Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.

1994 • 73 citations

Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development

1990 • 69 citations

Signal transduction of a tissue interaction during embryonic heart development.

1990 • 66 citations

Collagen-mediated dispersion of NBT-II rat bladder carcinoma cells.

1990 • 65 citations

E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line

1992 • 63 citations

The Multisubstrate Docking Site of the MET Receptor Is Dispensable for MET-mediated RAS Signaling and Cell Scattering

1999 • 63 citations

The expression of an Ets1 transcription factor lacking its activation domain decreases uPA proteolytic activity and cell motility, and impairs normal tubulogenesis and cancerous scattering in mammary epithelial cells

1998 • 62 citations

α2β1 Integrin is Required for the Collagen and FGF-1 Induced Cell Dispersion in a Rat Bladder Carcinoma Cell Line

1996 • 61 citations

Cell-Cell Dissociation upon Epithelial Cell Scattering Requires a Step Mediated by the Proteasome

1999 • 61 citations

Effect of Potent and Selective Inhibitors of the Grb2 SH2 Domain on Cell Motility

1999 • 58 citations

Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro.

1997 • 55 citations

Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells: Involvement of the MAPK pathway

1998 • 53 citations

Wortmannin Inhibits Spreading and Chemotaxis of Rat Osteoclasts In Vitro

1998 • 49 citations

Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line.

1990 • 44 citations

Hepatocyte Growth Factor and Transforming Growth Factor-.BETA. Stimulate both Cell Growth and Migration of Human Gastric Adenocarcinoma Cells.

1992 • 39 citations

Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation

1997 • 39 citations

Morphogenetic Effects of Neuregulin (Neu Differentiation Factor) in Cultured Epithelial Cells

1998 • 33 citations

Expression of c-ets-1 and uPA genes is associated with mammary epithelial cell tubulogenesis or neoplastic scattering.

1996 • 32 citations

Thyrocyte Migration and Histiotypic Follicle Regeneration Are Promoted by Epidermal Growth Factor in Primary Culture of Thyroid Follicles in Collagen Gel*

1991 • 31 citations

A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors

1996 • 22 citations

Focal adhesions

1999 • 5 citations

A hand across the Golgi?

1998 • 1 citations