Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

The Kidney: Physiology and Pathophysiology

1992 • 1,714 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Organogenesis of the kidney

1987 • 904 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

1989 • 664 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.

1992 • 612 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation

1987 • 555 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis

1993 • 504 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.

1993 • 434 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos.

1986 • 424 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.

1993 • 398 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

Embryonic induction - molecular prospects

1987 • 381 citations

Expression of immunoreactive E-cadherin adhesion molecules in human cancers.

1991 • 379 citations

Protocadherins: a large family of cadherin-related molecules in central nervous system.

1993 • 371 citations

Expression of E- and P-cadherin in gastric carcinomas.

1991 • 345 citations

Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium

1981 • 338 citations

Diffusible factors in vertebrate embryonic induction

1992 • 327 citations

In Vitro and in Vivo Consequences of VLA-2 Expression on Rhabdomyosarcoma Cells

1991 • 323 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

1990 • 299 citations

Expression of the Antimetastatic Gene nm23 in Human Breast Cancer: An Association WIth Good Prognosis

1991 • 298 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function

1990 • 286 citations

Morphogenetic Interaction between Embryonic Mouse Tissues separated by a Membrane Filter

1953 • 285 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis.

1991 • 252 citations

The Structure and Function of Intercellular Junctions in Cancer

1976 • 240 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

Epimorphin: A mesenchymal protein essential for epithelial morphogenesis

1992 • 222 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

Cell-adhesion molecule uvomorulin during kidney development

1985 • 189 citations

Down‐regulation of E‐cadherin expression in madin darby canine kidney (MDCK) cells inside tumors of nude mice

1991 • 183 citations

Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma

1991 • 180 citations

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor

1991 • 179 citations

Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.

1990 • 176 citations

E-cadherin: a differentiation marker in thyroid malignancies.

1993 • 172 citations

Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo

1990 • 171 citations

Unstable Expression of E‐Cadherin Adhesion Molecules in Metastatic Ovarian Tumor Cells

1989 • 157 citations

Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

1983 • 153 citations

New Aspects of Stroma-Parenchyma Relations in Mammary Gland Differentiation

1991 • 140 citations

Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

1993 • 137 citations

Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer

1992 • 137 citations

Histological typing of oral and oropharyngeal tumours

1971 • 133 citations

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

1991 • 116 citations

Molecular cloning and characterization of the human E-cadherin cDNA

1993 • 113 citations

The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis

1993 • 109 citations

Transient and locally restricted expression of the ros1 protooncogene during mouse development.

1991 • 102 citations

Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis

1992 • 102 citations

Defining E-cadherin-associated protein complexes in epithelial cells: plakoglobin β- and γ-catenin are distinct components

1993 • 100 citations

Developmental expression of syndecan, an integral membrane proteoglycan, correlates with cell differentiation

1991 • 99 citations

Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma.

1993 • 91 citations

Somatic mutations and human breast cancer. A Status Report

1992 • 90 citations

Branching morphogenesis of mouse salivary epithelium in basement membrane-like substratum separated from mesenchyme by the membrane filter

1991 • 87 citations

The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event

1993 • 87 citations

Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid

1992 • 87 citations

E-cadherin expression in a particular subset of sensory neurons

1992 • 83 citations

The structure of the gene coding for the mouse cell adhesion molecule uvomorulin

1991 • 80 citations

Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer

1994 • 79 citations

Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas.

1992 • 71 citations

Estradiol stimulates cadherin expression in rat granulosa cells

1989 • 70 citations

Decreased expression of E‐cadherin and increased invasive capacity in EBV‐LMP‐transfected human epithelial and murine adenocarcinoma cells

1992 • 69 citations

Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells: Possible involvement of plakoglobin

1993 • 69 citations

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck

2007 • 67 citations

Molecular diversity of cytokeratins: significance for cell and tumor differentiation.

1991 • 65 citations

Detection of HPV 6 and 11 in tumours of the upper respiratory tract using the polymerase chain reaction

1990 • 56 citations

L‐Cam expression in normal, premalignant, and malignant colon mucosa

1992 • 52 citations

Steroid/thyroid receptor-like proteins with oncogenic potential: a review.

1990 • 47 citations

Alterations in the expression of uvomorulin and Na+,K(+)-adenosine triphosphatase during mouse skin tumor progression.

1992 • 37 citations

Is epimorphin involved in vesicular transport?

1993 • 37 citations

Progressive stages of "transdifferentiation" from epidermal to mesenchymal phenotype induced by MyoD1 transfection, 5-aza-2'-deoxycytidine treatment, and selection for reduced cell attachment in the human keratinocyte line HaCaT.

1992 • 32 citations

Epimorphin is related to a new class of neuronal and yeast vesicle targeting proteins

1993 • 26 citations

Transformed growth phenotype of mouse mammary epithelium in primary culture induced by specific fetal mesenchymes

1992 • 21 citations

Expression of E-cadherin in embryogenetic ingression and cancer invasion.

1993 • 17 citations

A monoclonal antibody against an adult-specific cuticular protein of Tenebrio molitor (Insecta, Coleoptera)

1989 • 16 citations