Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells

1979 • 794 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Integrin signaling and cell growth control

1998 • 655 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Rho GTPases

1998 • 534 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells

1995 • 393 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

1998 • 338 citations

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

1987 • 334 citations

Tyrosine phosphorylation and cadherin/catenin function

1997 • 318 citations

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

1998 • 297 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Beta 1 integrin-dependent and -independent polymerization of fibronectin.

1996 • 292 citations

Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation.

1980 • 274 citations

Vinculin Is Part of the Cadherin–Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin

1998 • 260 citations

Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts.

1995 • 254 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells.

1996 • 224 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

1995 • 216 citations

Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of α-Catenin from the E-Cadherin·Catenin Complex

1998 • 206 citations

Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.

1994 • 184 citations

Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.

1991 • 174 citations

Vinculin Is Associated with the E-cadherin Adhesion Complex

1997 • 164 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells

1997 • 155 citations

Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212.

1990 • 149 citations

Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase

1996 • 137 citations

Developmental changes in expression of contractile and cytoskeletal proteins in human aortic smooth muscle.

1990 • 136 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Perturbation of beta 1-integrin function alters the development of murine mammary gland

1998 • 120 citations

Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours

1987 • 119 citations

Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules

1997 • 109 citations

A novel β1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle

1995 • 109 citations

The α4Subunit of Integrin Is Important for Neural Crest Cell Migration

1998 • 108 citations

Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events

1999 • 108 citations

Novel Isoform of β1 Integrin Expressed in Skeletal and Cardiac Muscle

1995 • 97 citations

Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domain.

1993 • 96 citations

α_v Integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development

1994 • 96 citations

Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development

1998 • 96 citations

Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway.

1996 • 79 citations

Vinculin and α-catenin: shared and unique functions in adherens junctions

1998 • 78 citations

Endothelial cells assemble two distinct α6β4-containing vimentin-associated structures: roles for ligand binding and the β4 cytoplasmic tail

1998 • 62 citations

Ligand-independent role of the β4 integrin subunit in the formation of hemidesmosomes

1998 • 61 citations

Hyperphosphorylation of β-Catenin on Serine-Threonine Residues and Loss of Cell–Cell Contacts Induced by Calyculin A and Okadaic Acid in Human Epidermal Cells

1997 • 57 citations

Intracellular signals direct integrin localization to sites of function in embryonic muscles.

1996 • 53 citations

The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.

1997 • 53 citations

Restoration of β1A Integrins is Required for Lysophosphatidic Acid-induced Migration of β1-null Mouse Fibroblastic Cells

1998 • 52 citations

αV Integrins on HT-29 Colon Carcinoma Cells: Adhesion to Fibronectin Is Mediated Solely by Small Amounts of αVβ6, and αVβ5 Is Codistributed with Actin Fibers

1997 • 43 citations

Differential utilization of VLA-4 (α4β1) and -5 (α5β1) integrins during the development of mouse bone marrow-derived mast cells

1996 • 36 citations

Cadherin Mediated Cell-Cell Adhesion is Regulated by Tyrosine Phosphatases in Human Keratinocytes

1998 • 19 citations