A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

SH2 and SH3 domains

1993 • 697 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

1992 • 335 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.

1990 • 193 citations

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.

1992 • 150 citations

Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.

1988 • 132 citations

Regulatory mechanisms for ras proteins

1992 • 129 citations

The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.

1991 • 128 citations

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

1991 • 117 citations

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.

1990 • 105 citations

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation.

1992 • 91 citations

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

1991 • 86 citations

Oncoprotein-Mediated Signalling Cascade Stimulates c-Jun Activity by Phosphorylation of Serines 63 and 73

1992 • 83 citations

Identification of autophosphorylation sites of HER2/neu.

1990 • 76 citations

The role of autophosphorylation in modulation of erbB-2 transforming function.

1990 • 53 citations

An oncogenic point mutation confers high affinity ligand binding to the neu receptor. Implications for the generation of site heterogeneity.

1992 • 48 citations

The Transforming Potential of the c-erbB-2 Protein Is Regulated by Its Autophosphorylation at the Carboxyl-Terminal Domain

1991 • 33 citations

Signal transduction by the neu/ebrB-2 receptor: A potential target for anti-tumor therapy

1992 • 24 citations

The erbB-2 Mitogenic Signaling Pathway: Tyrosine Phosphorylation of Phospholipase C-γ and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency

1991 • 21 citations

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.

1992 • 19 citations