TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Reduction of Background Problems in Nonradioactive Northern and Southern Blot Analyses Enables Higher Sensitivity Than 32P-Based Hybridizations

1993 • 407 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β

1989 • 286 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 272 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

1990 • 226 citations

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

1994 • 215 citations

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

1993 • 209 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Differentiation of Lens Tissue from the Progeny of Chick Retinal Pigment Cells Cultured In Vitro : A Demonstration of a Switch of Cell Types in Clonal Cell Culture

1973 • 200 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Transdifferentiation

1993 • 179 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

TGF-β1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization

1989 • 174 citations

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

1992 • 166 citations

Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor‐β type II receptor family

1993 • 164 citations

cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells.

1990 • 147 citations

Cytoskeleton and thyroglobulin expression change during transformation of thyroid epithelium to mesenchyme-like cells*

1988 • 138 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Tumor necrosis factor alpha (TNFα) and transforming growth factor β1 (TGFβ1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts

1993 • 131 citations

Cytodifferentiation and tissue phenotype change during transformation of embryonic lens epithelium to mesenchyme-like cells in vitro

1986 • 130 citations

Epithelium-dependent extracellular matrix synthesis in transforming growth factor-beta 1-growth-inhibited mouse mammary gland.

1990 • 124 citations

Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.

1991 • 104 citations

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

1990 • 95 citations

The murine type II TGF-β receptor has a coincident embryonic expression and binding preference for TGF-β1

1994 • 87 citations

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

1992 • 80 citations

Effects of transforming growth factor β on growth of human mammary epithelial cells in culture

1989 • 76 citations

TGFβ induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects

1993 • 72 citations

Type I Receptors Specify Growth-Inhibitory and Transcriptional Responses to Transforming Growth Factor β and Activin

1994 • 70 citations

Metanephric transforming growth factor-beta 1 regulates nephrogenesis in vitro

1993 • 61 citations

A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.

1994 • 54 citations

Protein kinase C modulation of fibronectin matrix assembly.

1993 • 46 citations

Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line.

1990 • 44 citations

Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

1988 • 32 citations

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways.

1993 • 30 citations

Molecular Cloning of a Mouse Counterpart for Human TGF-β Type I Receptor

1994 • 28 citations

Evidence For The Involvement of Protein Kinase Activity In Transforming Growth Factor-β Signal Transduction

1992 • 13 citations