Effect of Potent and Selective Inhibitors of the Grb2 SH2 Domain on Cell Motility

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

SH2 and SH3 domains

1993 • 697 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.

1979 • 300 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.

1990 • 229 citations

The actin cytoskeleton

1988 • 218 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

1995 • 180 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species

1992 • 171 citations

Epidermal growth factor induces rapid reorganization of the actin microfilament system in human A431 cells

1991 • 130 citations

The assembly of signalling complexes by receptor tyrosine kinases

1993 • 130 citations

Cell locomotion and tumor penetration

1977 • 127 citations

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

1993 • 108 citations

A study of an in vitro model for invasion of oral squamous cell carcinoma

1989 • 90 citations

Mechanisms of cell migration in the vertebrate embryo

1984 • 84 citations

Structure-Based Design and Synthesis of High Affinity Tripeptide Ligands of the Grb2-SH2 Domain

1998 • 82 citations

Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase

1996 • 77 citations

Specificity in recognition of phosphopeptides by src-homology 2 domains

1994 • 66 citations

Multiple Grb2-protein complexes in human cancer cells

1997 • 30 citations