Wortmannin Inhibits Spreading and Chemotaxis of Rat Osteoclasts In Vitro

Biostatistical Analysis

1996 • 36,713 citations

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1986 • 5,963 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Calcitonin alters behaviour of isolated osteoclasts

1982 • 509 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts.

1993 • 360 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

Osteoclastic bone resorption: In vitro analysis of the rate of resorption and migration of individual osteoclasts

1988 • 155 citations

Wortmannin, a specific inhibitor of phosphatidylinositol‐3 kinase, blocks osteoclastic bone resorption

1995 • 148 citations

Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.

1993 • 136 citations

Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity.

1995 • 130 citations

Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.

1994 • 123 citations

Phosphatidylinositol 3-Kinase Association with the Osteoclast Cytoskeleton, and Its Involvement in Osteoclast Attachment and Spreading

1997 • 82 citations

Novel functions of phosphatidylinositol 3-kinase in terminally differentiated cells

1995 • 72 citations

Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts

1997 • 60 citations

Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3-Kinase to Grb2·Sos Complexes in Human Monocytes

1995 • 56 citations

Intracellular Signalling: PI 3-kinase puts GTP on the Rac

1995 • 53 citations

Chemotaxis of newt eosinophils: calcium regulation of chemotactic response

1993 • 43 citations

Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro

1995 • 34 citations

Macrophage Colony-Stimulating Factor (M-CSF) Induces Migration in Osteoclasts in Vitro

1993 • 32 citations

17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase

1995 • 12 citations