DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

SH2 and SH3 domains

1993 • 697 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.

1990 • 146 citations

Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.

1993 • 136 citations

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

1990 • 120 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src.

1989 • 106 citations

Performance of an automated system for capillary microinjection into living cells

1988 • 98 citations

Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.

1992 • 87 citations

Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP‐kinase and focal adhesion kinase in cultured Swiss 3T3 cells

1993 • 78 citations

Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells

1993 • 51 citations

Protein tyrosine kinases, with emphasis on the Src family.

1994 • 50 citations

Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85

1994 • 34 citations