The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Ovarian development in Drosophila melanogaster

1970 • 1,436 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 • 1,253 citations

Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor

1996 • 982 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

On the control of germ cell development in Caenorhabditis elegans

1981 • 593 citations

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

1997 • 511 citations

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans

1992 • 503 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues

1996 • 491 citations

A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

1988 • 476 citations

Systematic gain-of-function genetics in Drosophila

1998 • 467 citations

Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons

1996 • 459 citations

frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance

1996 • 456 citations

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

1998 • 426 citations

Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.

1993 • 424 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans

1992 • 404 citations

Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells

1996 • 394 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein

1997 • 372 citations

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

1996 • 365 citations

Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans

1996 • 359 citations

DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane

1996 • 339 citations

Genetics of cell and axon migrations in Caenorhabditis elegans

1987 • 334 citations

The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells

1993 • 330 citations

DE-Cadherin Is Required for Intercellular Motility during Drosophila Oogenesis

1999 • 330 citations

slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila CEBP

1992 • 326 citations

Guidance Cues at the Drosophila CNS Midline: Identification and Characterization of Two Drosophila Netrin/UNC-6 Homologs

1996 • 322 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Gene replacement in Dictyostelium: generation of myosin null mutants.

1989 • 299 citations

Targeted Mutations in Cell Adhesion Genes: What Have We Learned from Them?

1996 • 295 citations

The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila

1991 • 281 citations

Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39

1993 • 261 citations

A mechanical function of myosin II in cell motility

1995 • 254 citations

A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans

1999 • 252 citations

Guidance of neurite outgrowth by pathways of substratum‐adsorbed laminin

1985 • 252 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

A gene involved in the development of the posterior body region of C. elegans

1986 • 236 citations

Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos

1993 • 222 citations

The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension.

1991 • 217 citations

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis.

1996 • 216 citations

The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.

1996 • 211 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis

1996 • 189 citations

The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system

1996 • 185 citations

HMG-CoA reductase guides migrating primordial germ cells

1998 • 183 citations

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

1995 • 183 citations

Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration

1992 • 182 citations

Neuronal Migrations and Axon Fasciculation Are Disrupted in ina-1 Integrin Mutants

1997 • 179 citations

Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position

1996 • 175 citations

The Drosophila Protein Dof Is Specifically Required for FGF Signaling

1998 • 166 citations

drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia.

1995 • 164 citations

Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system.

1996 • 146 citations

Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila

1998 • 137 citations

Cell interactions coordinate the development of the C. elegans egg-laying system

1990 • 136 citations

Control of cell fate in the tail region of C. elegans by the gene egl-5

1991 • 136 citations

Genes necessary for C. elegans cell and growth cone migrations

1995 • 134 citations

Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila

1998 • 131 citations

egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans

1997 • 129 citations

Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development

1996 • 126 citations

The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development

1998 • 122 citations

Drosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis.

1989 • 114 citations

Identification of Caenorhabditis elegans Genes Required for Neuronal Differentiation and Migration

1998 • 110 citations

DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo

1997 • 108 citations

Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes

1997 • 97 citations

Migration of glia along photoreceptor axons in the developing drosophila eye

1994 • 92 citations

Primordial Germ Cell Migration and the Assembly of the Drosophila Embryonic Gonad

1994 • 92 citations

Breathless, a Drosophila FGF receptor homolog, is required for the onset of tracheal cell migration and tracheole formation

1995 • 91 citations

Genetic analysis of Laminin A in Drosophila: extracellular matrix containing laminin A is required for ocellar axon pathfinding

1996 • 84 citations

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.

1992 • 80 citations

vab-8 Is a Key Regulator of Posteriorly Directed Migrations in C. elegans and Encodes a Novel Protein with Kinesin Motor Similarity

1998 • 76 citations

EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans

1999 • 73 citations

The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration

1996 • 72 citations

Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development.

1992 • 67 citations

ventral veinless, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila

1997 • 67 citations

hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1.

1996 • 63 citations

Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.

1993 • 62 citations

A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants

1991 • 60 citations

Identification of mutations that cause cell migration defects in mosaic clones

1999 • 56 citations

The Breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration

1995 • 55 citations

The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron

1999 • 43 citations

Hams and egls: genetic analysis of cell migration in Caenorhabditis elegans

1994 • 12 citations

Migration of Drosophila germ cells: analysis using enhancer trap lines

1993 • 11 citations