Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1998 • 949 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)

1989 • 931 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

Relationship of iron to oligondendrocytes and myelination

1996 • 696 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

1993 • 556 citations

Chronic Stage Multiple Sclerosis Lesions Contain a Relatively Quiescent Population of Oligodendrocyte Precursor Cells

1998 • 551 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

1998 • 538 citations

Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

1993 • 512 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

1998 • 476 citations

Neural apoptosis

1995 • 464 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination

1998 • 423 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Experimental allergic encephalomyelitis

1969 • 406 citations

Patterns of oligodendroglia pathology in multiple sclerosis

1994 • 403 citations

Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block

1996 • 401 citations

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

1995 • 393 citations

Genetic evidence for the involvement of τ in progressive supranuclear palsy

1997 • 387 citations

Control of oligodendrocyte number in the developing rat optic nerve

1994 • 385 citations

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

1994 • 384 citations

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

1994 • 373 citations

Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress

1996 • 369 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes

1997 • 352 citations

Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord

1998 • 342 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible

1997 • 330 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor

1994 • 318 citations

Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death

1997 • 312 citations

Microglia are the major cell type expressing MHC class II in human white matter

1987 • 302 citations

Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1983 • 295 citations

Recognition of a Peptide Antigen by Heat Shock--reactive γδ T Lymphocytes

1990 • 291 citations

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

1998 • 290 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

1998 • 285 citations

Multiple Sclerosis

1993 • 284 citations

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

1995 • 283 citations

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

1995 • 271 citations

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

1989 • 266 citations

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.

1981 • 263 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

1981 • 259 citations

Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro

1994 • 258 citations

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1997 • 255 citations

Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

1995 • 249 citations

The Application of Tissue Culture to the Study of Experimental “Allergic” Encephalomyelitis*

1961 • 246 citations

THE HISTOLOGY OF DISSEMINATED SCLEROSIS.

1916 • 245 citations

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1989 • 243 citations

BLOOD-BRAIN BARRIER DAMAGE IN ACUTE MULTIPLE SCLEROSIS PLAQUES

1991 • 235 citations

Multiple sclerosis

1993 • 229 citations

Oligodendrocytes in the early course of multiple sclerosis

1994 • 215 citations

Interleukin-2 as a neuroregulatory cytokine

1995 • 209 citations

Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia

1997 • 206 citations

Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions

1997 • 205 citations

Multiple sclerosis: Oligodendrocytes display cell death–related molecules in situ but do not undergo apoptosis

1997 • 204 citations

The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis

1998 • 203 citations

Cellular management of iron in the brain

1995 • 202 citations

Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes

1995 • 197 citations

Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy

1992 • 195 citations

Pathology of the early lesion in multiple sclerosis

1975 • 192 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis

1997 • 187 citations

Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

1996 • 184 citations

Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

1986 • 184 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS

1989 • 182 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

Primary demyelination in transgenic mice expressing interferon-γ

1997 • 180 citations

Nerve Growth Factor and Neurotrophin-3 Differentially Regulate the Proliferation and Survival of Developing Rat Brain Oligodendrocytes

1996 • 175 citations

The immunogenesis of the multiple sclerosis plaque

1971 • 171 citations

Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein

1990 • 165 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

1986 • 163 citations

Reversible Inhibitory Effects of Interferon‐γ and Tumour Necrosis Factor‐α on Oligodendroglial Lineage Cell Proliferation and Differentiation In Vitro

1996 • 162 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 161 citations

Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration.

1996 • 161 citations

Vascular changes and demyelination induced by the intraneural injection of tumour necrosis factor

1995 • 159 citations

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

1997 • 157 citations

K⁺Channel Expression and Cell Proliferation Are Regulated by Intracellular Sodium and Membrane Depolarization in Oligodendrocyte Progenitor Cells

1997 • 153 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

Ultrastructure of Multiple Sclerosis

1994 • 148 citations

The role of nitric oxide in multiple sclerosis

1997 • 143 citations

Sublytic complement attack induces cell cycle in oligodendrocytes.

1996 • 143 citations

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor‐α in the central nervous system

1997 • 142 citations

ICE/CED‐3 Family Executes Oligodendrocyte Apoptosis by Tumor Necrosis Factor

1997 • 141 citations

The Norton Lecture: a review of the oligodendrocyte in the multiple sclerosis lesion1Presented at the Albert Einstein College of Medicine, Bronx, NY, on February 3, 1997 in honor of the retirement of Dr. William T. Norton, a pioneer neurochemist in the myelin/oligodendrocyte arena.1

1997 • 140 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

Pathophysiology of oligodendroglial excitotoxicity

1996 • 137 citations

α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionate (AMPA) Receptors Mediate Excitotoxicity in the Oligodendroglial Lineage

1995 • 136 citations

Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: A new model for multiple sclerosis

1995 • 136 citations

Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis.

1997 • 134 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 133 citations

Fc Receptors for IgG on Cultured Human Microglia Mediate Cytotoxicity and Phagocytosis of Antibody-coated Targets

1994 • 133 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Cell death and birth in multiple sclerosis brain

1997 • 127 citations

Cystine Deprivation Induces Oligodendroglial Death: Rescue by Free Radical Scavengers and by a Diffusible Glial Factor

1996 • 125 citations

Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen species

1995 • 123 citations

Myelin Degeneration in Multiple System Atrophy Detected by Unique Antibodies

1998 • 122 citations

Oligodendrocyte Injury Is an Early Event in Lesions of Multiple Sclerosis

1993 • 121 citations

Basic Protein in Brain Myelin Is Phosphorylated by Endogenous Phospholipid-Sensitive Ca²⁺-Dependent Protein Kinase

1982 • 116 citations

Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction

1994 • 114 citations

A proliferative adult human oligodendrocyte progenitor

1995 • 114 citations

Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat

1996 • 113 citations

Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions

1976 • 113 citations

Selective Degeneration of Oligodendrocytes Mediated by Reactive Oxygen Species

1990 • 104 citations

Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison

1995 • 104 citations

The Pathobiology of the Oligodendrocyte

1997 • 103 citations

Glutamate regulates intracellular calcium and gene expression in oligodendrocyte progenitors through the activation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

1994 • 103 citations

Normal rat serum cytotoxicity against syngeneic oligodendrocytes

1989 • 102 citations

On the immunopathology of plaque development and repair in multiple sclerosis

1988 • 102 citations

Experimental allergic encephalomyelitis: an ultrastructural study of experimental demyelination in vitro.

1970 • 102 citations

Oligodendroglial cell death induced by oxygen radicals and its protection by catalase

1991 • 101 citations

Immune‐mediated demyelination

1993 • 99 citations

Theiler's Murine Encephalomyelitis Virus (TMEV)-Induced Demyelination: A Model for Human Multiple Sclerosis

1996 • 99 citations

Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy

1994 • 97 citations

Ampa/kainate receptor activation in murine oligodendrocyte precursor cells leads to activation of a cation conductance, calcium influx and blockade of delayed rectifying K+ channels

1994 • 97 citations

Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury

1996 • 95 citations

Calcium‐Stimulated Proteolysis in Myelin: Evidence for a Ca²⁺‐Activated Neutral Proteinase Associated with Purified Myelin of Rat CNS

1985 • 94 citations

Progressive supranuclear gaze palsy is in linkage disequilibrium with theτ and not the α-synuclein gene

1998 • 93 citations

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1970 • 91 citations

Identification of A2B5-positive putative oligodendrocyte progenitor cells and A2B5-positive astrocytes in adult human white matter

1999 • 89 citations

Enhanced expression of chemotactic receptors in multiple sclerosis lesions

1996 • 88 citations

Multiple Sclerosis

1997 • 87 citations

Antibody-independent complement activation by myelin via the classical complement pathway.

1982 • 86 citations

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease

1997 • 86 citations

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

1997 • 86 citations

A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis

1997 • 82 citations

Binding of complement component Clq to myelin oligodendrocyte glycoprotein: A novel mechanism for regulating CNS inflammation

1997 • 82 citations

TERMINAL COMPONENT OF COMPLEMENT (C9) IN CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS

1984 • 80 citations

Remyelination in the Human Central Nervous System

1989 • 80 citations

Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis

1998 • 80 citations

Fundamental Problems in the Pathology of Multiple Sclerosis and Allied Demyelinating Diseases

1951 • 78 citations

Expression of heat shock protein‐65 by oligodendrocytes in vivo and in vitro

1992 • 75 citations

Cytokine receptors on glial cells

1994 • 74 citations

Effect of tumor necrosis factor α and β on human oligodendrocytes and neurons in culture

1995 • 71 citations

Expression of Bcl‐2 in Adult Human Brain Regions with Special Reference to Neurodegenerative Disorders

1997 • 71 citations

Release of Leukotriene B₄ from Sublethally Injured Oligodendrocytes by Terminal Complement Complexes

1987 • 69 citations

Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes

1994 • 69 citations

Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination

1989 • 69 citations

Selective enrichment of T_h1 CD45RB^low CD4⁺ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis

1994 • 69 citations

Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death

1996 • 69 citations

Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes

1996 • 68 citations

Oligodendrocyte susceptibility to injury by T-cell perforin.

1990 • 67 citations

Glutamate Induces c‐fos Proto‐oncogene Expression and Inhibits Proliferation in Oligodendrocyte Progenitors: Receptor Characterization

1995 • 66 citations

Complement Regulatory Molecules on Human Myelin and Glial Cells: Differential Expression Affects the Deposition of Activated Complement Proteins

1996 • 65 citations

The expression of complement regulatory proteins by adult human oligodendrocytes

1998 • 64 citations

Immunology of multiple sclerosis.

1992 • 64 citations

Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2.

1995 • 62 citations

Increased levels of myelin basic protein transcripts gene in virus-induced demyelination

1986 • 61 citations

Multiple Sclerosis

1997 • 61 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

The role of macrophages in demyelination

1992 • 60 citations

Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumour necrosis factor

1994 • 58 citations

Non-MHC-Restricted Cell-Mediated Lysis of Human Oligodendrocytes In Vitro: Relation with CD56 Expression

1998 • 58 citations

Pathogenesis of myelin breakdown in demyelinating diseases: role of proteolytic enzymes.

1992 • 57 citations

Oligodendrocyte lysis by CD4⁺ T cells independent of tumor necrosis factor

1994 • 57 citations

Ultrastructural sequence of myelin degradation

1978 • 56 citations

Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system.

1995 • 53 citations

Killing of rat glial cells by complement: Deficiency of the rat analogue of CD59 is the cause of oligodendrocyte susceptibility to lysis

1993 • 53 citations

The role of nitric oxide in cell injury

1995 • 52 citations

Effect of optic nerve transection upon myelin protein gene expression by oligodendrocytes: evidence for axonal influences on gene expression

1990 • 52 citations

Inducible nitric oxide synthase in Theiler's murine encephalomyelitis virus infection

1997 • 52 citations

The pathogenesis of demyelinating disease

1994 • 51 citations

Reversible injury of cultured rat oligodendrocytes by complement.

1989 • 50 citations

Differential Sensitivity to Nitric Oxide in Immortalized, Cloned Murine Oligodendrocyte Cell Lines

1994 • 48 citations

New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro

1998 • 48 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Demyelinating Antibodies to Myelin Oligodendrocyte Glycoprotein and Galactocerebroside Induce Degradation of Myelin Basic Protein in Isolated Human Myelin

1997 • 47 citations

Do oligodendrocytes divide?

1996 • 46 citations

AMPA receptors shape Ca²⁺ responses in cortical oligodendrocyte progenitors and CG‐4 cells

1995 • 45 citations

Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.

1989 • 44 citations

Hydrolysis of myelin basic protein in human myelin by terminal complement complexes.

1988 • 44 citations

Compromised blood-nerve barrier, astrogliosis, and myelin disruption in optic nerves during fatal murine cerebral malaria

1997 • 44 citations

Radiation-induced Apoptosis of Oligodendrocytesin Vitro

1992 • 43 citations

Growth Factor-Induced Transcription of GluR1 Increases Functional AMPA Receptor Density in Glial Progenitor Cells

1997 • 42 citations

Specific induction of intracellular calcium oscillations by complement membrane attack on oligodendroglia

1993 • 42 citations

Cyclic AMP‐Elevating Agents Prevent Oligodendroglial Excitotoxicity

1998 • 41 citations

Phenotypic and cell cycle properties of human oligodendrocytes in vitro

1995 • 41 citations

Allergic Encephalomyelitis in Common Marmosets: Pathogenesis of a Multiple Sclerosis-like Lesion

1996 • 41 citations

Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis

1998 • 40 citations

Expression and regulation of a glutamate receptor subunit by bFGF in oligodendrocyte progenitors

1994 • 40 citations

Oligodendrocyte reactions and cell proliferation markers in human demyelinating diseases

1994 • 40 citations

Anin VitroModel of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis

1996 • 38 citations

Induction of oligodendrocyte apoptosis by C2-ceramide.

1997 • 38 citations

Immune complexes and the complement factors C4 and C3 in cerebrospinal fluid and serum from patients with chronic progressive multiple sclerosis

1984 • 37 citations

Glutamate-stimulated production of inositol phosphates is mediated by Ca2+ influx in oligodendrocyte progenitors

1997 • 37 citations

Ultrastructural sequence of myelin degradation

1978 • 36 citations

Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-?

1997 • 35 citations

Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes.

1993 • 35 citations

The role of calcium in rat oligodendrocyte injury and repair

1992 • 33 citations

Platelet-derived growth factor partly prevents chemically induced oligodendrocyte death and improves myelin-like membranes repair in vitro

1996 • 33 citations

Multiple sclerosis: a protective or a pathogenic role for heat shock protein 60 in the central nervous system?

1996 • 31 citations

Effects of tumor necrosis factor on inward potassium current and cell morphology in cultured human oligodendrocytes

1993 • 31 citations

Oligodendroglial pathology in canine distemper virus infection in vitro

1987 • 30 citations

Central demyelination induced in vivoby the calcium ionophore ionomycin

1994 • 30 citations

Signal transduction pathways in oligodendrocytes: Role of tumor necrosis factor‐α

1995 • 29 citations

γδ T-cell–human glial cell interactions. I. In vitro induction of γδ T-cell expansion by human glial cells

1997 • 25 citations

Depolarizing agents and tumor necrosis factor‐α modulate protein phosphorylation in oligodendrocytes

1994 • 24 citations

Molecular cloning of IL‐2Rα, IL‐2Rβ, and IL‐2Rγ cDNAs from a human oligodendroglioma cell line: Presence of IL‐2R mRNAs in the human central nervous system

1995 • 23 citations

Response of Human Oligodendrocytes to Interleukin-2

1997 • 23 citations

Morphology of demyelination in the human central nervous system

1992 • 22 citations

Antibody-dependent cellular cytotoxicity in antimyelin antibody-induced oligodendrocyte damage in vitro

1991 • 22 citations

Complement mediated serum cytotoxicity against oligodendrocytes: a comparison with other cells of the oligodendrocyte-type 2 astrocyte lineage

1990 • 22 citations

Human alpha tumor necrosis factor does not damage cultures containing rat Schwann cells and sensory neurons

1990 • 20 citations

Biogenic Aldehyde Metabolism in Rat Brain: Subcellular Distribution of Aldose Reductase and Valproate‐Sensitive Aldehyde Reductase

1982 • 20 citations

γδ T-cell–human glial cell interactions. II. Relationship between heat shock protein expression and susceptibility to cytolysis

1997 • 19 citations

Serum cytotoxicity to human and rat oligodendrocytes in culture

1990 • 18 citations

Lysis of human glial cells by major histocompatibility complex-unrestricted CD4+ cytotoxic lymphocytes

1993 • 17 citations

Imaging Ca2+ changes in individual oligodendrocytes attacked by T-cell perforin.

1991 • 17 citations

Lipid peroxides are generated by the fetal rat brain after episodes of global ischemia in utero.

1997 • 17 citations

Chronic Relapsing Experimental Allergic Encephalomyelitis in the SJL Mouse: Relevant Techniques

1996 • 17 citations

Effects of Hypoxia on Oligodendrocyte Signal Transduction

1993 • 16 citations

Regulation of gene expression in the nervous system by reactive oxygen and nitrogen species

1997 • 13 citations

Exogenous myelin basic protein promotes oligodendrocyte death via increased calcium influx

1995 • 13 citations

Hyperthermic injury of oligodendrocyte precursor cells: implications for dysmyelination disorders

1994 • 12 citations

Grovith factors fail to protect rat oligodendrocytes against humoral injury in vitro

1995 • 11 citations

Morphological and molecular response of the MOCH‐1 oligodendrocyte cell line to serum and interferon‐γ: Possible implications for demyelinating disorders

1995 • 10 citations

Deleted Work

1955 • 0 citations