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New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis

1993 • 572 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis

1993 • 359 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

Tumor necrosis factor‐α messenger RNA expression in patients with relapsing‐remitting multiple sclerosis is associated with disease activity

1995 • 336 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

1994 • 316 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease.

1996 • 270 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Multi-pin peptide synthesis strategy for T cell determinant analysis

1990 • 174 citations

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis.

1995 • 166 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.

1989 • 152 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 • 138 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

1995 • 121 citations

Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles

1994 • 119 citations

Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis

1990 • 115 citations

Development of Reactivity to New Myelin Antigens during Chronic Relapsing Autoimmune Demyelination

1993 • 98 citations

T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis

1991 • 85 citations

Identification of a novel T cell epitope of human proteolipid protein (residues 40–60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

1993 • 77 citations

Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review

1994 • 73 citations

Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes.

1995 • 70 citations

In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination.

1995 • 70 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides

1991 • 63 citations

Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals.

1995 • 61 citations

Immunological Aspects Of Demyelinating Diseases

1992 • 58 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1994 • 52 citations

The T‐lymphocyte response against myelin‐associated glycoprotein and myelin basic protein in patients with multiple sclerosis

1993 • 46 citations

Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis

1989 • 38 citations

T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S.

1994 • 34 citations

Identification of a second T cell epitore of human proteolipid protein (residues 89–106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

1994 • 34 citations

Optic neuritis and multiple sclerosis: the T cell repertoires to myelin proteins and MBP peptides change with time

2009 • 13 citations

[Expression of Fas-antigen on T cells in multiple sclerosis].

1995 • 9 citations