Non-MHC-Restricted Cell-Mediated Lysis of Human Oligodendrocytes In Vitro: Relation with CD56 Expression

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.

1986 • 1,106 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.

1989 • 492 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.

1994 • 438 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Protocols for Neural Cell Culture

1993 • 251 citations

Basis of microheterogeneity of myelin basic protein.

1976 • 200 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes

1998 • 162 citations

Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis

1994 • 162 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

The Immunology of Multiple Sclerosis and its Animal Model, Experimental Allergic Encephalomyelitis

1995 • 146 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus.

1994 • 136 citations

Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.

1996 • 130 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis.

1997 • 100 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

Cytokine-Induced Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Cultured Human Oligodendrocytes and Astrocytes

1991 • 83 citations

Chronologic localization of myelin‐reactive cells in the lesions of relapsing EAE

1993 • 78 citations

Culture of Glial Cells from Human Brain Biopsies

1997 • 70 citations

Oligodendrocyte susceptibility to injury by T-cell perforin.

1990 • 67 citations

A novel population of CD4+CD56+ myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule.

1996 • 64 citations

Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1

1995 • 62 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

Oligodendrocyte lysis by CD4⁺ T cells independent of tumor necrosis factor

1994 • 57 citations

A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptide^a

1995 • 35 citations

Myelin basic protein-specific CD4+ cytolytic T-lymphocyte clones isolated from multiple sclerosis patients

1988 • 27 citations

Absence of natural killer (NK) cell activity against oligodendrocytes in multiple sclerosis

1990 • 20 citations

Influx of nonactivated T lymphocytes into the cerebrospinal fluid during relapse of multiple sclerosis

1995 • 12 citations

Lymphokine-activated killer (LAK) and adherent LAK (A-LAK) activity in multiple sclerosis

1991 • 6 citations

MHC class I restricted killing of human oligodendrocytes by myelin basic protein peptide specific CD8 T lymphocytes

1997 • 4 citations

Unique T-Cell Receptor Junctional Sequences Found in Multiple Sclerosis and T-Cells Mediating Experimental Allergic Encephalomyelitis

1995 • 2 citations