Calcium‐Stimulated Proteolysis in Myelin: Evidence for a Ca²⁺‐Activated Neutral Proteinase Associated with Purified Myelin of Rat CNS

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION¹

1973 • 1,412 citations

THE REGIONAL AND SUBCELLULAR DISTRIBUTION OF 2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN THE CENTRAL NERVOUS SYSTEM

1967 • 458 citations

Regenerative changes in rat dorsal roots following wallerian degeneration

1963 • 309 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord

1972 • 259 citations

Degenerative changes in rat dorsal roots during wallerian degeneration

1963 • 230 citations

Neurofilament proteins of rat peripheral nerve and spinal cord.

1978 • 219 citations

Studies on 2′,3′-cyclic nucleotide-3′-phosphohydrolase from brain

1969 • 216 citations

Enzyme activity and composition of myelin and subcellular fractions in the developing rat brain

1969 • 207 citations

Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

1981 • 180 citations

PROTEOLYTIC ACTIVITY AND BASIC PROTEIN LOSS IN AND AROUND MULTIPLE SCLEROSIS PLAQUES: COMBINED BIOCHEMICAL AND EIISTOCHEMICAL OBSERVATIONS

1972 • 162 citations

Characterization of a brain calcium-activated protease that degrades neurofilament proteins

1982 • 160 citations

Bulk Preparation of CNS Cytoskeleton and the Separation of Individual Neurofilament Proteins by Gel Filtration: Dye‐Binding Characteristics and Amino Acid Compositions

1982 • 154 citations

Susceptibility of the Myelin‐Associated Glycoprotein and Basic Protein to a Neutral Protease in Highly Purified Myelin from Human and Rat Brain

1982 • 148 citations

ENZYME INACTIVITY OF MYELIN: HISTOCHEMICAL AND BIOCHEMICAL EVIDENCE

1963 • 128 citations

The suppression of experimental allergic encephalomyelitis and multiple sclerosis

1981 • 115 citations

Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system

1980 • 110 citations

Purification and characterization of two forms of Ca2+-activated neutral protease from calf brain.

1983 • 110 citations

Proteolysis and myelin breakdown: a review of recent histochemical and biochemical studies

1969 • 101 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Cholesterol Ester Metabolism in Rat Brain

1973 • 87 citations

A CALCIUM ACTIVATED PROTEASE IN SQUID AXOPLASM

1979 • 75 citations

Development of Rat Spinal Cord

1979 • 66 citations

Basic Proteins of Rodent Peripheral Nerve Myelin: Immunochemical Identification of the 21.5K, 18.5K, 17K, 14K, and P₂Proteins

1982 • 64 citations

ON THE COMPOSITION OF HUMAN MYELIN *

1967 • 63 citations

Development of Rat Spinal Cord

1979 • 61 citations

Elevated neutral protease activity in myelin from brains of patients with multiple sclerosis

1984 • 60 citations

Purification of a calcium-activated neutral proteinase from bovine brain

1983 • 54 citations

The role of proteolytic enzymes in demyelination in experimental allergic encephalomyelitis

1977 • 54 citations

Proteinase activity of myelin

1969 • 54 citations

Conversion of myelin-associated glycoprotein (MAG) to a smaller derivative by calcium activated neutral protease (CANP)-like enzyme in myelin and inhibition by E-64 analogue

1984 • 53 citations

The breakdown of myelin-bound proteins by intra- and extracellular proteases

1976 • 48 citations

Peptide hydrolases in spinal cord and brain of the rabbit

1972 • 44 citations

The action of snake venom, phospholipase A and trypsin on purified myelin in vitro

1976 • 37 citations

<b>Degradation of myelin basic protein by calcium-activated neutral protease (CANP)-like enzyme in myelin and inhibition by E-64 </b><b>analogue </b>

1982 • 34 citations

Degradation of myelin basic protein by calcium-activated neutral protease (CANP) in human brain and inhibition by E-64 analogue

1983 • 30 citations

l-Alany-?-NAPHTHYLAMIDASE IN RAT SPINAL CORD MYELIN

1968 • 27 citations

PROTEOLYTIC DIGESTION OF BOVINE BRAIN WHITE MATTER PROTEOLIPID

1975 • 27 citations

Proteinases and demyelination

1981 • 25 citations

PHOSPHOLIPID METABOLISM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: ACTIVITY OF BRAIN PHOSPHOLIPASE A₁, TOWARDS SPECIFICALLY LABELLED GLYCEROPHOSPHOLIPIDS

1974 • 23 citations

Degradation of myelin proteins by brain endogenous neutral protease

1983 • 21 citations

Tryptic hydrolysis of brain proteolipid

1967 • 19 citations

Non-osmotic swelling in purified bovine myelin

1973 • 17 citations

Action of phospholipase C (Bacillus cereus) on isolated myelin sheath preparations

1984 • 9 citations