Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

The Fas Death Factor

1995 • 4,070 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

The CTL's kiss of death

1995 • 504 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Human γδ+ T cells respond to mycobacterial heat-shock protein

1989 • 417 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Patterns of oligodendroglia pathology in multiple sclerosis

1994 • 403 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

1994 • 361 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

A Textbook of Neuropathology

1950 • 325 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

1996 • 316 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion

1994 • 284 citations

XVIII.–The Histology of Disseminated Sclerosis

1916 • 268 citations

THE HISTOLOGY OF DISSEMINATED SCLEROSIS.

1916 • 245 citations

Multiple Sclerosis: Immune System Molecule Expression in the Central Nervous System

1994 • 200 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 161 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes

1995 • 136 citations

Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells.

1993 • 135 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 133 citations

Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor

1995 • 132 citations

Fas antigen expression in brains of patients with Alzheimer-type dementia

1995 • 132 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Regulation of an oligodendrocyte progenitor cell line by the interleukin‐6 family of cytokines

1994 • 127 citations

Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ

1991 • 126 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

Selective Degeneration of Oligodendrocytes Mediated by Reactive Oxygen Species

1990 • 104 citations

On the immunopathology of plaque development and repair in multiple sclerosis

1988 • 102 citations

Oligodendroglial cell death induced by oxygen radicals and its protection by catalase

1991 • 101 citations

Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury

1996 • 95 citations

The role of the Fas lytic pathway in a perforin-less CTL hybridoma.

1994 • 86 citations

Fas antigen mRNA induction in postischemic murine brain

1994 • 76 citations

Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1-mediated mechanism

1994 • 71 citations

Culture of Glial Cells from Human Brain Biopsies

1997 • 70 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

Oligodendrocyte lysis by CD4⁺ T cells independent of tumor necrosis factor

1994 • 57 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Phenotypic and cell cycle properties of human oligodendrocytes in vitro

1995 • 41 citations

Anti-Fas Antibody Induces Different Types of Cell Death in the Human Histiocytic Cell Line, U937, and the Human B Cell Line, B104: The Role of Single-Strand DNA Breaks and Poly (ADP-Ribosyl)ation in Cell Death

1994 • 30 citations

The Molecular Mechanism of FasL-Mediated Cytotoxicity by CD4+ Th1 Clones

1995 • 22 citations

Fas-Based T Cell-Mediated Cytotoxicity

1995 • 20 citations

Biology of Fas.

1994 • 8 citations