Oligodendrocyte lysis by CD4⁺ T cells independent of tumor necrosis factor

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques

1992 • 315 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

1981 • 259 citations

Protocols for Neural Cell Culture

1993 • 251 citations

Cytotoxic Effects of Antigen- and Mitogen-Induced T Cells on Various Targets

1975 • 224 citations

Basis of microheterogeneity of myelin basic protein.

1976 • 200 citations

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 • 162 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 161 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 133 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ

1991 • 126 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

Antigen expression by glial cells grown in culture

1985 • 80 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

The requirements for triggering of lysis by cytolytic T lymphocyte clones. II. Cyclosporin A inhibits TCR-mediated exocytosis by only selectively inhibits TCR-mediated lytic activity by cloned CTL.

1989 • 58 citations

The role of cell surface recognition structures in the initiation of MHC-unrestricted ‘promiscuous’ killing by T cells

1989 • 57 citations

CD4⁺ T cell‐mediated killing of major histocompatibility complex class II‐positive antigen‐presenting cells (APC) III. CD4⁺ cytotoxic T cells induce apoptosis of APC

1992 • 53 citations

Apoptosis is induced in cells with cytolytic potential by L-leucyl-L-leucine methyl ester.

1992 • 48 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Peptide specificities of myelin basic protein‐reactive human T‐cell clones

1988 • 40 citations

Major histocompatibility complex-unrestricted cytolytic activity of human T cells. Analysis of precursor frequency and effector phenotype.

1987 • 40 citations

Distinct pathways of CD4 and CD8 cells induce rapid target DNA fragmentation.

1991 • 39 citations

Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets.

1992 • 37 citations

Multiple sclerosis: experimental and clinical aspects.

1984 • 35 citations

Production of transmembrane and secreted forms of tumor necrosis factor (TNF)-alpha by HIV-1-specific CD4+ cytolytic T lymphocyte clones. Evidence for a TNF-alpha-independent cytolytic mechanism.

1992 • 35 citations

Generation propagation, and targeting of human CD4+ helper/killer T cells induced by anti-CD3 monoclonal antibody plus recombinant IL-2. An efficient strategy for adoptive tumor immunotherapy.

1992 • 35 citations

Recovery of myelin basic protein reactive T cells from spinal cords of Lewis rats with autoimmune encephalomyelitis.

1984 • 32 citations

Experimental Autoimmune Demyelination: Chronic Relapsing Models and Their Therapeutic Implications for Multiple Sclerosis^a

1984 • 30 citations

Myelin basic protein-specific CD4+ cytolytic T-lymphocyte clones isolated from multiple sclerosis patients

1988 • 27 citations

Survey of the Association of Deoxyribonuclease I Polymorphism with Disease

1993 • 22 citations

Absence of natural killer (NK) cell activity against oligodendrocytes in multiple sclerosis

1990 • 20 citations

Lysis of human glial cells by major histocompatibility complex-unrestricted CD4+ cytotoxic lymphocytes

1993 • 17 citations

A previously unrecognized large fraction of cytotoxic lymphocyte precursors is present in CD4+ human peripheral blood T cells

1989 • 15 citations

Characteristics of in vitro cytotoxic effects of myelin basic protein-reactive T cell lines on syngeneic oligodendrocytes

1990 • 12 citations

Major histocompatibility complex class II-restricted cytotoxicity by self-myelin basic protein-reactive T-cell hybridomas: evidence for a tumour necrosis factor-independent nucleolytic mechanism.

1993 • 6 citations

Generation and cytotoxic profile of human peripheral blood CD4 ⁺ T lymphocytes

1992 • 3 citations