Lysis of human glial cells by major histocompatibility complex-unrestricted CD4+ cytotoxic lymphocytes

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques

1992 • 315 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

Intraventricular hemorrhage in the premature infant—current concepts. Part I

1989 • 252 citations

Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients

1989 • 251 citations

Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

1984 • 209 citations

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 • 162 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.

1983 • 134 citations

Surface markers of cloned human T cells with various cytolytic activities.

1981 • 132 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is restricted to the DR region of the MHC complex.

1988 • 110 citations

Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

1984 • 92 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells.

1990 • 86 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

Interleukin‐2 levels in serum and cerebrospinal fluid of multiple sclerosis patients

1988 • 60 citations

The role of cell surface recognition structures in the initiation of MHC-unrestricted ‘promiscuous’ killing by T cells

1989 • 57 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Induction of cytotoxicity in human peripheral blood mononuclear cells by monoclonal antibody OKT3.

1987 • 44 citations

Peptide specificities of myelin basic protein‐reactive human T‐cell clones

1988 • 40 citations

Major histocompatibility complex-unrestricted cytolytic activity of human T cells. Analysis of precursor frequency and effector phenotype.

1987 • 40 citations

Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets.

1992 • 37 citations

Myelin basic protein-specific CD4+ cytolytic T-lymphocyte clones isolated from multiple sclerosis patients

1988 • 27 citations

The relationship of interleukin-2 and soluble interleukin-2 receptors to intrathecal immunoglobulin synthesis in patients with multiple sclerosis

1991 • 27 citations

Absence of natural killer (NK) cell activity against oligodendrocytes in multiple sclerosis

1990 • 20 citations

Fine analysis of cytolytic and natural killer T lymphocytes in the CSF in multiple sclerosis and other neurologic diseases

1987 • 19 citations

Generation of cytolytic activity with anti-CD3 monoclonal antibodies involves both IL-2-independent and -dependent components.

1990 • 17 citations

A previously unrecognized large fraction of cytotoxic lymphocyte precursors is present in CD4+ human peripheral blood T cells

1989 • 15 citations

DNA synthesis by young adult human-derived astrocytes in vitro

1989 • 10 citations

Clonal activation of cytotoxic lymphocyte precursors by monoclonal anti-CD3 antibody: analysis of feeder cell requirements

1987 • 7 citations

Myelin basic protein, MHC restriction molecules and T cell repertoire.

1990 • 6 citations

Fine Analysis of Cytolytic and Natural Killer T Lymphocytes in the Cerebrospinal Fluid of Multiple Sclerosis and other Neurological Diseases Patients

1987 • 3 citations