Genetic polymorphisms in xenobiotic metabolism

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

1995 • 8,575 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1994 • 1,319 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Monographs on the Evaluation of Carcinogenic Risks to Humans

1991 • 845 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

1988 • 753 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

1978 • 686 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism

1986 • 582 citations

Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

1989 • 579 citations

Evolution of the P450 gene superfamily:

1990 • 508 citations

Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in vitro of amino acid variants

1994 • 491 citations

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

1990 • 487 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

1991 • 449 citations

Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population

1994 • 440 citations

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

1993 • 431 citations

Human ArylamineN-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression

1990 • 429 citations

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

1992 • 417 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Glutathione S-transferases, structure, regulation, and therapeutic implications

1993 • 409 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

1986 • 382 citations

Isoenzyme(S) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study

1990 • 372 citations

Mutagens-carcinogens in foods.

1983 • 372 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Human cytochromes P450: problems and prospects

1992 • 364 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Human Glutathione S-Transferases

1998 • 353 citations

Acetylator genotype and arylamine-induced carcinogenesis

1988 • 325 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu‐class Glutathione S‐Transferase Genes

1992 • 284 citations

Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

1994 • 276 citations

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility

1991 • 274 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Intracellular Binding and Transport of Hormones and Xenobiotics by Glutathiones-Transferases

1988 • 272 citations

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

1992 • 269 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1994 • 269 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid

1967 • 261 citations

CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.

1994 • 253 citations

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

1990 • 236 citations

A tobacco smoke-derived nitrosamine, 4-(methytnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytocbrome P450s including the polymorphic human cytochrome P4502D6

1991 • 235 citations

Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification

1988 • 233 citations

Ethnic Differences in Drug Metabolism

1982 • 229 citations

Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis.

1992 • 229 citations

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

1991 • 222 citations

Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.

1994 • 218 citations

Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology.

1993 • 209 citations

Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression

1988 • 207 citations

Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk.

1992 • 203 citations

Clinical Pharmacokinetics of Isoniazid

1979 • 202 citations

Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer

1993 • 199 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

Evolution of cytochrome P-450 proteins.

1987 • 190 citations

Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver.

1990 • 182 citations

Genetics of Human Alcohol and Aldehyde Dehydrogenases

1986 • 177 citations

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

1991 • 176 citations

The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma

1991 • 176 citations

N-acetyltransferase polymorphism

1991 • 171 citations

Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours

1994 • 170 citations

Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene

1994 • 168 citations

Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms.

1993 • 165 citations

Human P450PCN1: Sequence, Chromosome Localization, and Direct Evidence through cDNA Expression That P450PCN1 Is Nifedipine Oxidase

1988 • 164 citations

Human CYP1A1 (cytochrome P1450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population

1991 • 163 citations

Lung Cancer and the Debrisoquine Metabolic Phenotype

1990 • 162 citations

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

1989 • 159 citations

Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.

1985 • 156 citations

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors.

1987 • 152 citations

FAMILIAL INCIDENCE OF LOW PSEUDOCHOLINESTERASE LEVEL

1956 • 148 citations

The human glutathione S‐transferases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes

1984 • 148 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype

1990 • 140 citations

Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.

1984 • 135 citations

Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

1988 • 134 citations

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population

1993 • 129 citations

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6

1992 • 123 citations

Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

1989 • 120 citations

Glutathione S-Transferase and Epoxide Hydrolase Activity in Human Leukocytes in Relation to Risk of Lung Cancer and Other Smoking-Related Cancers

1992 • 113 citations

Molecular genetics of the N-acetyltransferases

1993 • 112 citations

Chromosomal localization of human genes for arylamine N-acetyltransferase

1994 • 110 citations

GST1 gene deletion determined by polymerase chain reaction

1990 • 109 citations

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility

1992 • 108 citations

Primary and secondary structural analyses of glutathione S-transferase π from human placenta

1990 • 107 citations

Restriction fragment length polymorphism of the human CYP 2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer

1994 • 105 citations

Metabolism of methyl chloride by human erythrocytes

1989 • 99 citations

Genetic Studies on Alcohol-Metabolizing Enzymes: Detection of Isozymes in Human Hair Roots

1980 • 98 citations

p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.

1994 • 96 citations

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1991 • 95 citations

On the nature of susceptibility to cancer. The presidential address

1980 • 93 citations

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

1991 • 91 citations

Foreign Compound Metabolism

1985 • 90 citations

Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase δ is composed of two distinct subunits (B1 and B2)

1985 • 88 citations

Comparison of a novel thin-layer chromatographic—fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

1992 • 87 citations

Hereditary interindividual differences in the glutathione transferase activity towards trans-stilbene oxide in resting human mononuclear leukocytes are due to a particular isozyme(s)

1985 • 85 citations

Biochemical Individuality and Its Implications for Drug and Carcinogen Metabolism: Recent Insights from Acetyltransferase and Cytochrome P4501a2 Phenotyping and Genotyping in Humans

1994 • 81 citations

Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung

1993 • 80 citations

Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate

1992 • 78 citations

Genetic polymorphisms of drug metabolism*

1990 • 77 citations

Evidence for two closely related isozymes of arylamine N‐acetyltransferase in human liver

1989 • 77 citations

[1] P450 gene nomenclature based on evolution

1991 • 75 citations

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus

1993 • 75 citations

Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk.

1988 • 75 citations

Isolation and characterization of two mouse Pi-class glutathione S-transferase genes

1994 • 73 citations

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

1989 • 72 citations

Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.

1987 • 71 citations

Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3.

1993 • 69 citations

Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation

1989 • 67 citations

A study of the structures of the YaYa and YaYc glutathione S-transferases from rat liver cytosol Evidence that the Ya monomer is responsible for lithocholate-binding activity

1981 • 66 citations

The pharmacogenetics of chemical carcinogenesis

1992 • 64 citations

Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds.

1983 • 64 citations

Localization of the CYP2D Gene Locus to Human Chromosome 22q13.1 by Polymerase Chain Reaction, in Situ Hybridization, and Linkage Analysis

1993 • 61 citations

Different forms of human liver glutathione <scp>s</scp>-transferases arise from dimeric combinations of at least four immunologically and functionally distinct subunits

1985 • 61 citations

Glutathione S-transferase class ? in French alcoholic cirrhotic patients

1991 • 60 citations

Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.

1992 • 59 citations

Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer

1994 • 55 citations

Glutathione conjugation; mechanisms and biological significance

1989 • 54 citations

Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol

1993 • 53 citations

Purification and characterization of three forms of glutathione S-transferase A. A comparative study of the major YaYa-, YbYb- and YcYc-containing glutathione S-transferases

1982 • 53 citations

Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity

1989 • 52 citations

Debrisoquine oxidation phenotype and susceptibility to lung cancer.

1990 • 51 citations

Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi

1989 • 47 citations

Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility

1994 • 47 citations

Cloning, sequencing, and regulation of rat liver carnitine octanoyltransferase: transcriptional stimulation of the enzyme during peroxisome proliferation

1988 • 41 citations

Metabolic factors in cancer susceptibility.

1990 • 40 citations

The human Hb (MU) class glutathione S-transferases are encoded by a dispersed gene family

1991 • 39 citations

The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.

1988 • 39 citations

Variation in the expression of Mu-class glutathione S-transferase isoenzymes from human skeletal muscle. Evidence for the existence of heterodimers

1991 • 38 citations

Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians

1992 • 36 citations

Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines

1992 • 36 citations

Chromosomal assignment and linkage analysis of the human glutathione S-transferase ? gene (GSTM1) using intron specific polymerase chain reaction

1992 • 36 citations

Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.

1992 • 35 citations

[15] Genetic analysis of cytochrome P450 system

1991 • 33 citations

Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.

1987 • 30 citations

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages

1989 • 28 citations

Polymorphic Oxidation of Debrisoquine in Women with Breast Cancer

1991 • 27 citations

The gene for the microsomal glutathione S-transferase is on human chromosome 12

1990 • 24 citations

Case-control study of cigarette smoking and primary hepatoma in an aflatoxin-endemic region of China: a protective effect

1991 • 22 citations

Polymorphisms of human cholesterol 7α-hydroxylase

1992 • 21 citations

Glutathione S-transferase isoenzymes in human bronchoal veolar lavage: a possible early marker for the detection of lung cancer

1990 • 21 citations

&lt;b&gt;PHYSIOLOGY AND MOLECULAR BIOLOGY OF ARYLAMINE &lt;/b&gt;&lt;b&gt;&lt;i&gt;N&lt;/i&gt;-ACETYLTRANSFERASES &lt;/b&gt;

1992 • 18 citations

Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4

1990 • 17 citations

Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis

1991 • 14 citations

Genetics of malignant disease

1994 • 8 citations