P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

The classification of cancer of the rectum

1932 • 1,529 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support

1989 • 747 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Convention on nomenclature for DNA cytometry

1984 • 601 citations

The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases

1986 • 539 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

1990 • 259 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

1991 • 192 citations

DNA flow cytometry in solid tumors: practical aspects and clinical applications.

1989 • 156 citations

Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa

1992 • 112 citations

Consensus review of the clinical utility of dna flow cytometry in colorectal cancer

1993 • 112 citations

Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer.

1993 • 102 citations

Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors.

1991 • 88 citations

Constitutive expression of multidrug resistance in human colorectal tumours and cell lines

1993 • 52 citations

Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa

1991 • 47 citations

Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE)

1993 • 44 citations

Glutathione S-transferases in noral and malignant human colon tissue

1991 • 41 citations

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples

1991 • 40 citations

MDR1 gene expression in primary colorectal carcinomas

1993 • 30 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 30 citations

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

1993 • 27 citations

Flowcytometric analysis of multidrug-resistance-associated antigen (P-Glycoprotein) and DNA ploidy in human colon cancer

1992 • 12 citations

Clinical implications of multidrug resistance to chemotherapy

1991 • 8 citations

Detection of P-glycoprotein in solid tumors by flow cytometry.

1993 • 5 citations

Understanding anticancer drug resistance: Opportunities for modulation and impact on new drug design

1992 • 5 citations

P-glycoprotein expression in human colon carcinoma and its relationship to DNA ploidy, local invasion and disease relapse

1994 • 2 citations