Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on the interaction of daunomycin with deoxyribonucleic acid

1982 • 923 citations

Mechanism of multidrug resistance

1988 • 630 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.

1989 • 132 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

1990 • 121 citations

Increased Cytosolic pH in Multidrug-Resistant Human Lung Tumor Cells: Effect of Verapamil

1989 • 120 citations

Induction by verapamil of a rapid increase in ATP consumption in multidrug‐resistant tumor cells

1988 • 109 citations

Quantitative Determination of Factors Contributing to Doxorubicin Resistance in Multidrug-Resistant Cells

1989 • 102 citations

Anthracycline incorporation in human lymphocytes. Kinetics of uptake and nuclear concentration

1989 • 87 citations

Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

1987 • 79 citations

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance

1990 • 65 citations

Enhanced efflux of [3H]vinblastine from Chinese hamster ovary cells transfected with a full-length complementary DNA clone for the mdr1 gene.

1989 • 64 citations

Location and dynamics of anthracyclines bound to unilamellar phosphatidylcholine vesicles

1985 • 60 citations

Immunohistochemical detection of P‐glycoprotein in human tumor cells with a low degree of drug resistance

1989 • 53 citations

On mathematical modeling of critical variables in cancer treatment (goals: Better understanding of the past and better planning in the future)

1986 • 49 citations

Comparison of anthracycline concentrations in S180 cell lines of varying sensitivity

1983 • 44 citations

Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.

1988 • 41 citations

Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and-sensitive cell lines

1987 • 40 citations

Multiple mechanisms of adriamycin resistance in the human leukemia cell line CCRF-CEM

1989 • 25 citations

Cellular daunomycin fluorescence in multidrug resistant 2780AD cells and its relation to cellular drug localisation

1991 • 17 citations

Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells

1990 • 14 citations

Drug-Resistance Patterns Assessed From Tumor Marker Analysis

1989 • 12 citations