Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

1988 • 415 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

1989 • 250 citations

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

1988 • 244 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

1992 • 212 citations

DNA topoisomerases from rat liver: physiological variations

1983 • 206 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

MDR₁ transcript levels as an indication of resistant disease in acute myelogenous leukaemia

1990 • 184 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Proliferation dependence of topoisomerase II-mediated drug action

1986 • 170 citations

Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.

1988 • 166 citations

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1992 • 166 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.

1988 • 162 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

1991 • 149 citations

SCHEDULE DEPENDENCY OF THE ANTILEUKEMIC ACTIVITY OF THE PODOPHYLLOTOXIN‐DERIVATIVE VP 16–213 (NSC‐141540) IN L1210 LEUKEMIA

1973 • 148 citations

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.

1987 • 147 citations

Topoisomerase-specific drug sensitivity in relation to cell cycle progression.

1987 • 144 citations

In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.

1978 • 135 citations

Variation of Proliferative Activity in Leukemic Cell Populations of Patients with Acute Leukemia*

1967 • 123 citations

Long chemotherapy-free remissions after single-cycle timed-sequential chemotherapy for acute myelocytic leukemia

1980 • 121 citations

P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy.

1991 • 120 citations

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

1992 • 110 citations

Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.

1987 • 109 citations

A fluorescence enhancement assay for cellular DNA damage.

1982 • 108 citations

Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia

1993 • 105 citations

Prediction of response to chemotherapy in acute myelocytic leukemia

1980 • 104 citations

Cell cycle stage-dependent variations in drug-induced topoisomerase II mediated DNA cleavage and cytotoxicity

1987 • 103 citations

Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines.

1991 • 103 citations

DNA topoisomerase activities in concanavalin A‐stimulated lymphocytes

1984 • 102 citations

The contribution of blast cell properties to outcome variation in acute myeloblastic leukemia (AML)

1982 • 102 citations

Topoisomerase II levels during granulocytic maturation in vitro and in vivo.

1991 • 100 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

Current chemotherapeutic treatment approaches to the management of previously untreated adults with de novo acute myelogenous leukemia.

1987 • 91 citations

Cell death induced by topoisomerase inhibitors

1991 • 89 citations

Correlation of occult clonogenic leukemia drug sensitivity with relapse after autologous bone marrow transplantation

1991 • 86 citations

Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.

1993 • 85 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Additional Members of the Rat Liver Lamin Polypeptide Family

1989 • 84 citations

A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.

1993 • 82 citations

A two-step timed sequential treatment for acute myelocytic leukemia

1989 • 80 citations

Therapy of acute myelogenous leukemia.

1987 • 77 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

Mechanism of epipodophyllotoxin-induced cell death in poly(adenosine diphosphate-ribose) synthesis-deficient V79 Chinese hamster cell lines.

1990 • 73 citations

Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.

1993 • 68 citations

Human DNA topoisomerase II: evaluation of enzyme activity in normal and neoplastic tissues

1990 • 62 citations

Cytotoxicity of Adriamycin and Daunorubicin for Normal and Leukemia Progenitor Cells of Man<xref ref-type="fn" rid="fn2">2</xref>

1979 • 59 citations

Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide.

1989 • 56 citations

Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26

1991 • 55 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

1991 • 53 citations

The heritable nature of clonal characteristics in acute myeloblastic leukemia

1981 • 52 citations

Multidrug resistance (MDR 1) in leukemia: is it time to test? [editorial] [see comments]

1992 • 51 citations

Clinical correlations of leukemic clonogenic cell chemosensitivity assessed by in vitro continuous exposure to drugs.

1983 • 48 citations

P-glycoprotein expression and in vitro reversion of doxorubicin resistance by verapamil in clinical specimens from acute leukaemia and myeloma.

1991 • 47 citations

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line

1993 • 46 citations

In vitro culture of clonogenic leukaemic cells in acute myeloid leukaemia: growth pattern and drug sensitivity

1983 • 43 citations

Correlation of drug sensitivity in vitro with clinical responses in childhood acute myeloid leukemia

1986 • 37 citations

Effect of Oxygen on the Cytotoxicity and Antitumor Activity of Etoposide<xref ref-type="fn" rid="FN2">2</xref>

1985 • 36 citations

The distribution of immunoreactive topoisomerase II Protein in human tissues and neoplasms.

1992 • 34 citations

The multidrug resistance phenotype in human cancer.

1991 • 31 citations

In vitro evaluation of combination drug purging for autologous bone marrow transplantation.

1990 • 30 citations

Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II

1992 • 30 citations

Prediction of response to chemotherapy in acute leukemia by in vitro drug sensitivity testing on leukemic stem cells.

1984 • 29 citations

Altered function of DNA topoisomerases as a basis for antineoplastic drug action.

1988 • 29 citations

Enhanced expression of DNA topoisomerase II by recombinant human granulocyte colony-stimulating factor in human leukemia cells.

1990 • 24 citations

Etoposide-induced DNA cleavage in human leukemia cells

1987 • 23 citations

Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia

1986 • 23 citations

Topoisomerase-II activity in human leukemic and lymphoblastoid cells

1985 • 22 citations

New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.

1991 • 21 citations

Etoposide in the treatment of leukemias.

1992 • 20 citations

m-AMSA as a probe for transport phenomena associated with anthracycline resistance

1984 • 18 citations

Cellular and pharmacologic aspects of drug resistance in acute myeloid leukemia

1991 • 15 citations

Daunorubicin accumulation by human myeloblasts varying in anthracycline resistance

1984 • 14 citations

In vitro sensitivity of myeloblast clonogenic cells to doxorubicin, aclacinomycin A, and 4'-O-tetrapyranyl-doxorubicin: correlations with clinical responses.

1984 • 10 citations

Etoposide in the management of leukemia: a review.

1991 • 10 citations

Sensitivity of fresh acute myeloid leukemia cells to etoposide: relationship with cell growth characteristics and DNA single-strand breaks

1992 • 8 citations

Loss of viability and induction of DNA damage in human leukemic myeloblasts and lymphocytes by m-AMSA

1986 • 7 citations