Quantitative and qualitative aspects of topoisomerase I and II alpha and beta in untreated and platinum/cyclophosphamide treated malignant ovarian tumors.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Chemotherapy of ovarian cancer

1998 • 303 citations

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

1989 • 250 citations

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

1988 • 244 citations

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

1990 • 226 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.

1991 • 165 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II .beta. isoform

1991 • 153 citations

Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

1990 • 143 citations

Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.

1992 • 138 citations

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.

1990 • 124 citations

P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy.

1991 • 120 citations

Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin.

1992 • 114 citations

Ovarian cancer biology.

1991 • 114 citations

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

1992 • 110 citations

Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines.

1991 • 103 citations

Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase π gene expression in primary and relapsed state adult and childhood leukaemias

1992 • 99 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line

1989 • 89 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1988 • 76 citations

Mechanisms of resistance to drugs that inhibit DNA topoisomerases.

1991 • 72 citations

Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture.

1992 • 71 citations

Human DNA topoisomerase II: evaluation of enzyme activity in normal and neoplastic tissues

1990 • 62 citations

Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line

1991 • 43 citations

The distribution of immunoreactive topoisomerase II Protein in human tissues and neoplasms.

1992 • 34 citations

Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II

1992 • 30 citations

Old drugs revisited, new drugs, and experimental approaches in ovarian cancer therapy.

1991 • 22 citations