Multidrug resistance in breast cancer: Mechanisms, strategies

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy:133 Randomised Trials involoving 31 000 Recurrences and 24 000 Deaths Among 75 000 Women (Summary)

1993 • 967 citations

Breast Cancer

1992 • 695 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma.

1994 • 473 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Breast Cancer

1992 • 303 citations

Cancer chemotherapy and biological response modifiers annual

1987 • 273 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

1989 • 250 citations

Breast Cancer

1992 • 249 citations

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

1988 • 244 citations

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

1991 • 208 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1992 • 166 citations

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.

1991 • 165 citations

Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.

1992 • 138 citations

Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II.

1990 • 91 citations

Determinants of Response to the DNA Topoisomerase II Inhibitors Doxorubicin and Etoposide in Human Lung Cancer Cell Lines

1992 • 90 citations

Expression of P-glycoprotein in breast cancer tissue and in vitro resistance to doxorubicin and vincristine

1991 • 86 citations

Expression of mdr1 and gst-π in human breast tumours: comparison to in vitro chemosensitivity

1990 • 86 citations

Prognostic relevance of P-glycoprotein expression in breast cancer

1995 • 81 citations

Multidrug resistance from the clinical point of view

1991 • 47 citations

DNA topoisomerases and topoisomerase inhibitors.

1994 • 25 citations

Tyrosine kinase receptor — nuclear protooncogene interactions in breast cancer

1991 • 20 citations

Characterization of a Topoisomerase II Gene Rearrangement in a Human Small-Cell Lung Cancer Cell Line

1992 • 20 citations