Expression of resistance factors (P-glycoprotein, glutathione S-transferase-π, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Statistical Methods for Rates and Proportions.

1973 • 1,326 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Statistical Methods for Rates and Proportions

1974 • 555 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

1985 • 501 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Cell growth and differentiation

2005 • 226 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis (review).

1990 • 169 citations

P-Glycoprotein expression in treated and untreated human breast cancer

1989 • 133 citations

Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer.

1988 • 126 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

Detection of fos protein during osteogenesis by monoclonal antibodies.

1988 • 123 citations

Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.

1989 • 106 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Proto-oncogene fos: a multifaceted gene

1986 • 101 citations

Increased epidermal growth factor receptor in multidrug‐resistant human neuroblastoma cells

1988 • 98 citations

Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations

1993 • 96 citations

Structure of the human genomic glutathione S-transferase-π gene

1989 • 94 citations

Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes

1991 • 90 citations

Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small cell lung carcinomas of smokers

1991 • 78 citations

Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers.

1989 • 70 citations

Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

1986 • 65 citations

Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity.

1991 • 60 citations

Monoclonal antibodies to glutathione S‐Transferase π–immunohistochemical analysis of human tissues and cancers

1991 • 55 citations

Immunohistochemical Detection of P Glycoprotein, Glutathione S Transferase and DNATopoisomerase II in Human Tumors

1992 • 50 citations

Relationship of inherent resistance to doxorubicin, proliferative activity and expression of P-glycoprotein 170, and glutathione S-transf erase-π in human lung tumors

1992 • 42 citations

Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma.

1989 • 40 citations

Detection of Drug Resistance and P-Glycoprotein in Human Renal Cell Carcinomas

1990 • 37 citations

Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.

1988 • 36 citations

Immunological detection of Chinese hamster ovary cells expressing a multidrug resistance phenotype.

1985 • 34 citations

Overexpression of P-glycoprotein rat hepatocellular carcinomas induced with N-nitrosomorpholine

1990 • 27 citations

Detection of the multidrug resistant phenotype in human tumours by monoclonal antibodies and the streptavidin-biotinylated phycoerythrin complex method

1989 • 27 citations

Immunocytochemical detection of oncoproteins in animal and human tumor lines with acquired or inherent multidrug resistance.

1992 • 11 citations

OVEREXPRESSION OF C-FOS AND C-ERBB1 ENCODED PROTEINS IN SQUAMOUS-CELL CARCINOMAS OF THE LUNG OF SMOKERS

1992 • 10 citations