p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies

Proposals for the classification of the myelodysplastic syndromes

1982 • 3,616 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Arabinosyl Cytosine: A Useful Agent in the Treatment of Acute Leukemia in Adults

1968 • 559 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

p53 mutation is associated with progression in follicular lymphomas

1993 • 394 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

p53 expression and prognosis in gastric carcinoma

1992 • 333 citations

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

1992 • 317 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes.

1986 • 225 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

P53 gene mutations in acute myeloid leukemia with 17p monosomy

1991 • 184 citations

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood

1993 • 179 citations

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.

1991 • 171 citations

Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

1992 • 166 citations

Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.

1992 • 147 citations

Prognostic factors in adult de novo myelodysplastic syndromes treated by intensive chemotherapy

2008 • 140 citations

p53 Alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes

1994 • 133 citations

Mutations in the p53 gene in myelodysplastic syndromes.

1991 • 123 citations

Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.

1992 • 98 citations

High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells

1993 • 85 citations

Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis.

1994 • 84 citations

P53 gene mutations in acute myelogenous leukaemia

1992 • 59 citations

Clonal expansion of p53 mutant cells in leukemia progression in vitro.

1994 • 40 citations

Expression of the multidrug resistance P-glycoprotein and its relationship to hematological characteristics and response to treatment in myelodysplastic syndromes.

1994 • 39 citations

P53 mutations in myelodysplastic syndromes.

1992 • 38 citations

Translocations (5;17) and (7;17) in patients with de novo or therapy-related myelodysplastic syndromes or acute nonlymphocytic leukemia

1990 • 30 citations

p53 gene mutations and loss of a chromosome 17p in Philadelphia chromosome (Ph1)-positive acute leukemia.

1993 • 27 citations

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

1993 • 27 citations

Rearrangement and expression of the p53 gene in myelodysplastic syndrome and acute myeloid leukemia.

1990 • 13 citations

Deleted Work

1955 • 0 citations