Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in The Netherlands

1977 • 837 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS*

1979 • 336 citations

Polychlorinated biphenyls and the developing nervous system: Cross-species comparisons

1990 • 323 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

Cancer mortality among workers in chemical plant contaminated with dioxin

1991 • 286 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

A critical review of the developmental toxicity and teratogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin: Recent advances toward understanding the mechanism

1990 • 235 citations

Induction of Liver Tumors in Sherman Strain Female Rats by Polychlorinated Biphenyl Aroclor 1260 2

1975 • 235 citations

Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship.

1973 • 218 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats

1987 • 184 citations

Polychlorinated biphenyls and polybrominated biphenyls

2001 • 180 citations

Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1984 • 165 citations

TEN-YEAR MORTALITY STUDY OF THE POPULATION INVOLVED IN THE SEVESO INCIDENT IN 1976

1989 • 154 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

Impairment of thymus‐dependent immune functions by exposure of the developing immune system to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)

1977 • 136 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes in Immunocompetence: Possible Mechanisms

1991 • 130 citations

Polychlorinated Dibenzo-p-dioxins and Polychlorinated Dibenzofurans: The Risks to Human Health. A Review

1989 • 111 citations

The association between soft tissue sarcomas and exposure to phenoxyacetic acids. A new case-referent study

1988 • 111 citations

Cytosolic and Nuclear Binding of 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin to the AhReceptor in Extra‐Hepatic Tissues of Rats and Mice

1982 • 103 citations

Is environmental carcinogenesis modulated by host polymorphism?

1991 • 96 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.

1988 • 84 citations

Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus

1991 • 82 citations

Dose-dependent elevation of Ah receptor binding by TCDD in rat liver

1987 • 81 citations

Dioxins and the ah receptor

1989 • 74 citations

Detection of the 2,3,7,8-tetpachlorodibenzo-p-dioxin (TCDD) receptor in rat liver by isoelectric focusing in polyacrylamide gels

1978 • 74 citations

Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment

1993 • 73 citations

Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: Comparison between defined mixtures and their constituents

1991 • 71 citations

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species

1986 • 70 citations

Ontogenetic Expression of Regulatory and Structural Gene Products Associated with the Ah Locus

1980 • 70 citations

Variations in extent of aryl hydrocarbon hydroxylase induction in cultured human lymphocytes.

1973 • 61 citations

Increases in cytochrome P-450 mediated 17β-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a two-stage hepatocarcinogenesis model

1988 • 61 citations

Induction of Liver Tumors in Female Sherman Strain Rats by Polybrominated Biphenyls<xref ref-type="fn" rid="FN2">2</xref>

1981 • 52 citations

The trace chemistries of fire hypothesis: Review and update

1984 • 44 citations

Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin

1991 • 44 citations

Integrated approach for evaluating species and interindividual differences in responsiveness to dioxins and structural analogs.

1992 • 40 citations

Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus

1984 • 37 citations

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Vol. 18: Polychlorinated Biphenyls and Polybrominated Biphenyls. Lyon. International Agency for Research on Cancer, 1978, 140 S., 2 Abb., 11 Tab., 390 Lit.

1979 • 36 citations

Toxicity equivalents and EPA's risk assessment of 2,3,7,8-TCDD

1991 • 34 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 33 citations

Genetic And Molecular Aspects Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Action

1990 • 31 citations

Mechanism of action of toxic halogenated aromatics.

1985 • 29 citations

The Air Force health study: An epidemiologic investigation of health effects in Air Force personnel following exposure to herbicides, serum dioxin analysis of 1987 examination results

1992 • 27 citations

Important aspects of the evidence for TCDD carcinogenicity in man.

1993 • 26 citations

Mechanism of Action of Toxic Halogenated Aromatics

1985 • 24 citations

Effects of 2,3,7,8-Tetrachlorodibenzofuran (TCDF) on the Immune System in Guinea Pigs

1979 • 21 citations

Hypergastrinemia is associated with decreased gastric acid secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats

1990 • 15 citations

THE TOXICOLOGY OF 2,3,7,8-TETRACHLORODIBENZO- <italic>p</italic> -DIOXIN AND ITS STRUCTURAL ANALOGUES

1979 • 15 citations

Ah receptor: relevance of mechanistic studies to human risk assessment.

1987 • 13 citations

Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment

1993 • 9 citations

Conquering the Monster—The Photochemical Destruction of Chlorodioxins

1978 • 8 citations

Mitosis stimulation near wounds by temporary membrane lesions of increased permeability

1991 • 5 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes In Immunocompetence : Possible Mechanisms

1991 • 3 citations

Ah Receptor: Relevance of Mechanistic Studies to Human Risk Assessment

1987 • 2 citations

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