Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

The role of 8-hydroxyguanine in carcinogenesis

1990 • 732 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

The AH-receptor: genetics, structure and function

1993 • 437 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

1992 • 242 citations

Genotoxic effects of estrogens

1990 • 227 citations

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

1994 • 196 citations

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

1990 • 189 citations

Identification of a Rat Adrenal Cytochrome P450 Active in Polycyclic Hydrocarbon Metabolism as Rat CYP1B1

1995 • 169 citations

Carcinogenicity of TCDD: Experimental, Mechanistic, and Epidemiologic Evidence

1994 • 169 citations

Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA

1988 • 161 citations

Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction.

1994 • 158 citations

DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol

1994 • 152 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

Oxidative DNA damage — The effects of certain genotoxic and operationally non-genotoxic carcinogens

1994 • 110 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals

1995 • 98 citations

Classification of members of the Ah gene battery

1992 • 95 citations

Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

1993 • 75 citations

Dioxins and the ah receptor

1989 • 74 citations

Comparison of oxidative damage to rat liver DNA and RNA by primary nitroalkanes, secondary nitroalkanes, cyclopentanone oxime, and related compounds.

1991 • 67 citations

The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis

1990 • 58 citations

Modeling the Number and Size of Hepatic Focal Lesions Following Exposure to 2,3,7,8-TCDD

1996 • 55 citations

Nuclear distribution of aflatoxin B1 and its interaction with histones in rat liver in vivo.

1980 • 48 citations

Catalysis of the oxidation of steroid and stilbene estrogens to estrogen quinone metabolites by the β-naphthoflavone-inducible cytochrome P450 IA family

1992 • 45 citations