The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

Enzyme induction in the cytochrome P-450 system

1990 • 631 citations

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1991 • 576 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Molecular genetics of the P-450 superfamily

1990 • 496 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

1987 • 340 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

The Ah receptor and the mechanism of dioxin toxicity

1991 • 330 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

1991 • 289 citations

Cancer mortality among workers in chemical plant contaminated with dioxin

1991 • 286 citations

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

1988 • 268 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex

1989 • 215 citations

Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

1991 • 213 citations

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation

1993 • 190 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.

1987 • 167 citations

Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

1984 • 164 citations

Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.

1989 • 161 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

1985 • 145 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.

1991 • 136 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

1992 • 126 citations

Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles.

1990 • 122 citations

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

1989 • 111 citations

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin

1991 • 110 citations

Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: Structure-activity relationships as Ah receptor agonists and partial antagonists

1990 • 109 citations

Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats

1987 • 108 citations

Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.

1991 • 104 citations

Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin.

1988 • 97 citations

Classification of members of the Ah gene battery

1992 • 95 citations

Detection and characterization of 63H92,3,7,8-tetrachlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line*1

1990 • 91 citations

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.

1989 • 90 citations

Superinduction of CYP1A1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor.

1992 • 89 citations

Ultraviolet photoproducts of tryptophan can act as dioxin agonists.

1991 • 86 citations

The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1990 • 86 citations

Characterization of multiple forms of the Ah receptor: comparison of species and tissues

1989 • 85 citations

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1992 • 85 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.

1988 • 84 citations

Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse.

1991 • 83 citations

Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180

1991 • 82 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17β-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression

1990 • 82 citations

Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting.

1992 • 82 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) enhances terminal differentiation of cultured human epidermal cells

1985 • 79 citations

Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.

1988 • 78 citations

Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten.

1991 • 74 citations

Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.

1989 • 73 citations

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.

1988 • 73 citations

Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2

1990 • 71 citations

Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 71 citations

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species

1986 • 70 citations

Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1992 • 69 citations

Differential gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Noncoordinate regulation of a TCDD-induced aldehyde dehydrogenase and cytochrome P-450c in the rat.

1988 • 69 citations

Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7

1992 • 66 citations

Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer

1992 • 64 citations

Production ofahreceptor ligands in rat fecal suspensions containing tryptophan or indole‐3‐carbinol

1991 • 63 citations

Arachidonic acid metabolism by dioxin-induced cytochrome P-450: A new hypothesis on the role of P-450 in dioxin toxicity

1990 • 63 citations

Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines

1985 • 62 citations

Use of artificial intelligence in structure—affinity correlations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor ligands

1991 • 62 citations

Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.

1989 • 58 citations

Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase.

1992 • 57 citations

Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.

1991 • 56 citations

Mechanism of Action of a Repressor of Dioxin-Dependent Induction of Cyplal Gene Transcription

1992 • 54 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations

Detection and characterization of Ah receptor in tissue and cells from human tonsils

1991 • 49 citations

Induction of 7-ethoxycoumarin O-deethylase activity in cultured human epithelial cells by 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD): Evidence for TCDD receptor

1983 • 47 citations

Ah receptor for 2,3,7,8‐ tetrachlorodibenzo‐p‐Dioxin: Ontogeny in chick embryo liver

1986 • 45 citations

Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.

1986 • 45 citations

Detection of the Ah receptor in rainbow trout: Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-P-dioxmin in cell culture

1991 • 43 citations

Induction of aryl hydrocarbon hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines

1989 • 39 citations

The aryl hydrocarbon (Ah) receptor

1988 • 38 citations

Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines

1987 • 38 citations

Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: Charge heterogeneity and ATP binding properties

1991 • 38 citations

The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line

1991 • 38 citations

In vitro transformation of the human Ah receptor and its binding to a dioxin response element.

1992 • 33 citations

Dioxin Toxicity. New Studies Prompt Debate, Regulatory Action

1991 • 32 citations

The receptor and dioxin toxicity: From rodent to human tissues

1985 • 30 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: II. B cell activation

1991 • 30 citations

Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor

1991 • 29 citations

Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin

1989 • 27 citations

Characterization of a specific binding protein for 2,3,7,8-tetrachlorodibenzo-p-dioxin in human thymic epithelial cells.

1989 • 23 citations

Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors

1991 • 21 citations

Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.

1991 • 21 citations

In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines

1991 • 21 citations

Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase in hepatoma cells

1992 • 21 citations

Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: Characterization of 6-[125I]methyl-8-iodo-1, 3-dichlorodibenzofuran-Ah receptor complexes

1991 • 21 citations

Equivalent molecular mass of cytosolic and nuclear forms of Ah receptor from Hepa-1 cells determined by photoaffinity labeling with 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin

1990 • 17 citations

Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental Ah receptor—A QSAR analysis

1990 • 17 citations

Nondetectable concentrations of human placental ah receptors are associated with potent induction of microsomal benzo6a9pyrene hydroxylase in individuals exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans

1986 • 16 citations

Filtration assay for quantitation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) specific binding to whole cells in culture

1990 • 16 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: I. Similarities to Staphylococcus aureus Cowan Strain I (SAC) in the in vitro T-dependent antibody response

1991 • 15 citations

Superinduction of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase by the inhibition of protein synthesis

1991 • 15 citations

The stability of dioxin-receptor ligands influences cytochrome P450IA1 expression in human keratinocytes

1992 • 14 citations

Factors affecting the toxicity of dioxin-like toxicants: a molecular approach to risk assessment of dioxins

1992 • 14 citations

Ah receptor mediating induction of cytochrome P450IA1 in a novel continuous human liver cell line (Mz-Hep-1)

1991 • 13 citations

Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line

1992 • 12 citations

Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor

1992 • 12 citations

More Pieces in the Dioxin Puzzle

1991 • 11 citations

7-Substituted-2,3-dichlorodibenzo-p-dioxins as competitive ligands for the Ah receptor: Quantitative structure-activity relationships (QSARs) and a comparison of human receptor with Ah receptor from rodents

1990 • 6 citations

Ribonuclease inhibits Ah receptor transformation in vitro

1991 • 4 citations

US government orders new look at dioxin

1991 • 3 citations

ATP promotes the appearance of two DNA-binding forms of the Ah receptor

1991 • 3 citations

A Unique Lab Design Fits the British to a Tea

1991 • 2 citations

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